BBML

Biological and Biomimetic Materials Laboratory

Our Research

The Biological and Biomimetic Materials Laboratory (BBML) is guided by Prof. Ali Miserez. We study natural multifunctional materials that feature unique (or combination of) properties not achieved in man-made materials. Nature processes complex, tailored, structural materials, in an aqueous environment under ambient temperature and pressure (or less) using natural compounds. These naturally selected, time-tested biomaterials are recognized as powerful model systems, and their energy-efficient synthesis confers the motivation for our research. Understanding the underlying “green chemistry” can potentially offer sustainable alternatives to engineer existing as well as new materials. We endeavor to mimic these key structural, biochemical, and physicochemical principles that are discovered in the model systems and envision to overcome scientific challenges in diverse fields.

Research Approach

We discover and explore employing biomimetic-thinking methodologically using a multidisciplinary approach. Critical technological and scientific breakthroughs in the past allow us to brainstorm and study biological structures in a refined way. We identify and characterize proteins in the natural materials; recreate their synthetic analogs applying design strategies to emulate functional mimicries. For this, we accumulate creative ideas and techniques, adopted from:

Biochemistry: Protein identification, isolation, sequencing, recombinant protein expression.

Biophysics: Spectroscopy, X-ray diffraction, single-molecule force spectroscopy.

Material's characterization: Micro-nano structure, mechanical properties at various length scales, structure-process-property relationships.

Focus Areas

whelk egg to feature Bioelastomeric Membranes & Coiled-Coil Engineering

Bioelastomeric Membranes & Coiled-Coil Engineering

Bioelastomers in nature are fascinating materials because some of them own unique combinations of structural and physicochemical properties. In our lab, we explore the bioelastomers that derive their properties from coiled-coil proteins, such as the marine snail's egg capsules capable of effective dissipation of tidal energy.

Learn more.
Mussels underwater to feature Mechanisms of Biofouling Adhesion & Anti-Adhesive Coating

Mechanisms of Biofouling Adhesion & Anti-Adhesive Coating

The projects focus to counter marine biofouling problems, which causes a significant economic and environmental impact. We understudy the adhesive proteins of marine foulers that drive the robust underwater adhesion. Efforts are also directed towards the development of methods to assess fouling and anti-adhesive coatings.

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Squid beak to feature Molecular Biomimetics of Non-Mineralized Hard Tissues

Molecular Biomimetics of Non-Mineralized Hard Tissues

Unlike hard tissues, nature also employs dense protein cross-linking, and/or formation of polysaccharide/protein complexes to impart strength and wear-resistance functionalities. Recognition of this novel paradigm offers for characterization, biomimetic synthesis of robust and biocompatible structural polymers with little or no mineral content.

Learn more.
Mantis Shrimp to feature Biomineralized Structures with Graded/Modulated Properties

Biomineralized Structures with Graded/Modulated Properties

Projects explore biomineralized composites with unexpected inorganic materials that are assembled in a highly controlled manner exhibiting tailored functionalities. We also engage in developing in situ mechanical testing methods to reveal structure-properties relationships across multiple length scales.

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Coacervates with DOX fluorescence microscopy to feature Liquid Liquid Phase Separation

Liquid-Liquid Phase Separation

Liquid-liquid phase separation gives rise to fluidic droplets, which are found across multiple length scales of the biological media. By performing highly differentiated functions, these droplets act as dynamic “membraneless organelles” that allow the living system to rapidly assemble (and disassemble) molecular collectives and switch on –or turn off– new functionalities.

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Highlighted Papers

Nanoscale Wetting and Mechanical Characterization of Peptide Coacervates on Supported Lipid Bilayers by Atomic Force Microscopy,Small Methods, 2026.

Fluid protein condensates for bio-inspired applications,Nature Reviews Bioengineering, 2024.

Fluid protein condensates for bio-inspired applications,Nature Reviews Bioengineering, 2023.

Squid suckerin microneedle arrays for tunable drug release, Journal of Materials Chemistry B, 2017.

Cross-linking Chemistry of Squid Beak, Journal of Biological Chemistry, 2010.

Team

With an interdisciplinary team and collaborations (local and international) we have access to comprehensive methods, specialized instruments, and skills for research advancement.

Prof. Ali Gilles Tchenguise Miserez

Principal Investigator

Dr. Sushanth Gudlur

Principal Research Fellow

Dr. Loke Jun Jie

Research Fellow & Safety Officer

Bui My Hanh

Research Assistant

Dr. Soner Karabacak

Research Fellow

Dr. Soheil Haddadzadegan

Research Fellow

Dr. Pooja Sharma

Research Fellow

Dr. Xiaojuan XU

Research Fellow

Dr. Sabrina Peter

Research Fellow

Dr. Vignesh Athiyarath

Research Fellow

Khwajah Syed Maricar

Ph.D. Student

Filipe Viana Ferreira

Ph.D. Student

Chen Zilin

Ph.D. Student

Felicia Lim Jia Jia

Project Officer

Neo Qi Ying

Ph.D. Student

Liu Yiting

Ph.D. Student

Mahsa Ghafouri

Ph.D. Student

Mai Le Ngoc

Ph.D. Student

News

1
Oct 26
plant
Publications

Peptide Coacervates with Cathepsin B-Triggered Intracellular Cargo Release

Our latest work "Peptide Coacervates with Cathepsin B-Triggered Intracellular Cargo Release" presents smart peptide droplets that carry cargo into cells and release it only when a cancer linked enzyme is present. Classic linkers fail inside these dense droplets, while our new motif FRFV stays active, giving a clear rule for targeted delivery. Read more

15
Sept 26
suckerin
Publications

Synthetic Hagfish Slime Hydrogels With Hyper‐Extensibility, Swellability and Self‐healing in Seawater

Inspired by hagfish ocean defense, our paper Synthetic Hagfish Slime Hydrogels With Hyper‐Extensibility, Swellability and Self‐healing in Seawater recreates its tough stretchy slime as a soft lifelike gel that loves seawater and mends itself. Woken by natural sea minerals, it strengthens when pulled and is simple to shape for future soft materials. Read more

23
Jun 26
mantis
Publications

Peptide coacervate–mediated siRNA delivery to enhance colorectal cancer immunotherapy

Most bowel tumors switch off immune attack, so current drugs often fail. As described in our work we built soft peptide droplets that quiet tumor defenses while waking T cells, restoring immunity and slowing growth in living models. Read more

October 2026

Peptide Coacervates with Cathepsin B-Triggered Intracellular Cargo Release

Publications

Our latest work, "Peptide Coacervates with Cathepsin B-Triggered Intracellular Cargo Release" explores peptide coacervates formed by liquid to liquid phase separation as intracellular carriers with tunable flow behavior, selective cargo uptake and efficient cell entry. By encoding protease sensitive motifs directly into the phase separating peptides, we aim for localized enzyme driven disassembly without broad changes in acidity, salt, heat or redox state. Since enzyme action inside dense droplets is limited by poor partitioning and hidden cleavage sites, classic linkers lose function while our new motif FRFV shaped by cathepsin B preferences stays active and releases cargo inside cancer cells. This shows that cleavage motifs must be redesigned for the dense phase, giving a rational route to smart peptide droplets for targeted intracellular delivery.

September 2026

Microdroplets Reduce Colorectal Tumour Growth at Potentially Lower Cost

Our Research in the News

Warm congratulations to our PhD student Chen Zilin on her first author paper in Biomaterials on soft peptide droplets that wake immune cells to fight bowel cancer. Her work on dual silencing of both sides of the checkpoint handshake was featured in NTU news and showed strong tumor control on par with antibody treatment in preclinical models. We are so proud of this wonderful achievement and grateful to all collaborators.

September 2026

Synthetic Hagfish Slime Hydrogels With Hyper‐Extensibility, Swellability and Self‐healing in Seawater

Publications

Inspired by the hagfish, a humble ocean dweller that instantly releases amazingly tough and stretchy slime to stay safe from predators. As presented in our paper "Synthetic Hagfish Slime Hydrogels With Hyper‐Extensibility, Swellability and Self‐healing in Seawater," we have recreated that wonder in our lab as a soft lifelike gel that adores seawater, stretches beautifully, and mends itself. Activated by the natural minerals already present in the sea, it grows stronger when pulled, just like real slime but even tougher. It is simple to prepare, easy to shape and full of promise for the future of gentle and resilient materials.

June 2026

Peptide coacervate–mediated siRNA delivery to enhance colorectal cancer immunotherapy

Publications

Most bowel tumors hide from the immune system by switching off attacking immune cells, so current checkpoint drugs rarely work for this common tumor type. As described in our recent work "Peptide coacervate–mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy," we built soft peptide droplets that deliver silencing RNA to both sides of the problem, quieting the off switch on tumor cells and the matching brake on immune cells. Guided by an immune seeking tag, our droplets find T cells easily, wake them up and boost their attack signals, while untargeted droplets disarm tumor cells in parallel. Together in living models, this dual silencing brings more active immune cells into the tumor, restores local immunity and slows tumor growth, opening a hopeful path for hard to treat bowel cancer.

June 2026

Peptide–Amphiphile Complex Coacervates for High-Capacity Genetic Material Delivery

Publications

Delivering gene medicine without viruses is hard, as carriers must hold a lot, stay stable in the body and still release cleanly inside cells, especially in guarded places like the eye. As described in our paper "Peptide–amphiphile complex coacervates for high-capacity genetic material delivery under physiological conditions," we created soft peptide droplets that form on their own in the body using a simple programmable design boosted by a natural helper molecule for extra strength. Tough outside yet smart inside, they stay intact in blood like surroundings and changing conditions, then gently fall apart once inside cells to free their cargo without harsh escape tricks. Kind to delicate retinal layers and red blood cells, they carry even very large gene instructions and switch them on, opening a hopeful route from small RNA toward future large gene treatments for the eye and beyond.

January 2026

Nanoscale Wetting and Mechanical Characterization of Peptide Coacervates on Lipid Bilayers

Publications

Small peptide droplets hold great promise for carrying medicine into cells, yet success depends on how they touch, spread and press on cell membranes. As described in our paper "Nanoscale Wetting and Mechanical Characterization of Peptide Coacervates on Supported Lipid Bilayers by Atomic Force Microscopy," we built a gentle fluid based probe that lets us feel single droplets on membrane like surfaces while viewing them in lifelike detail. Using a tunable peptide family, we show that droplet makeup, cargo and membrane type change how they wet and how soft or firm they feel. This reveals simple physical rules for smarter delivery design and gives a new way to study soft droplets where biology truly happens.

we created soft peptide droplets that form on their own in the body using a simple programmable design boosted by a natural helper molecule for extra strength. Tough outside yet smart inside, they stay intact in blood like surroundings and changing conditions, then gently fall apart once inside cells to free their cargo without harsh escape tricks. Kind to delicate retinal layers and red blood cells, they carry even very large gene instructions and switch them on, opening a hopeful route from small RNA toward future large gene treatments for the eye and beyond.

Careers

We are always looking for outstanding researchers. Please contact Prof. Ali Miserez (ALI.MISEREZ@ntu.edu.sg), attach your CV and state your reason for applying. You may also apply via the links indicated

We are currently looking for research fellows/senior research fellows to work on an exciting interdisciplinary project in the area of protein-based biopolymers, with an overarching goal to produce eco-friendly and biodegradable biopolymers. See the links below for more details on the job scope and requirements.

Senior Research Fellow

Research Fellow

Contact

+6563168979




Centre for Biomimetic Sensor Science (CBSS), 50 Nanyang Drive, Research Techno Plaza (RTP), Level 6, X-Frontier Block, Nanyang Technological University (NTU), Singapore 637553.