Professor Chen Wei Ning, William

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Michael Fam Endowed Chair Professor in Food Science and Technology School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 Director, NTU Food Science and Technology Programme (FST) Director, Singapore Agri-food Innovation Lab (SAIL) Scientific Director, Singapore Future Ready Food Safety Hub (FRESH) Tel: (65) 6316 2870 Email: WNChen@ntu.edu.sg

Publications

• Cui X, Ng KR, Chai KF, Chen W* (2022) Clinically relevant materials & applications inspired by food technologies. EBioMedicine, 75:103792.
• Chin YL, Chai KF, Chen W* (2021) Upcycling of brewers' spent grains via solid-state fermentation for the production of protein hydrolysates with antioxidant and techno-functional properties. Food Chem X. 13:100184.
• Ng KR, Lyu XM, Teng TS, Zhang JH, Chen W* (2021) Food Safety Assessment of an Engineered Yeast-derived Flavonoids Extract via in vitro cellular model of the Human Gut-Liver-Kidney-Blood axis. J. Functional Foods, revised
• Gupta S, Chen W* (2021) A metabolomics approach to evaluate post-fermentation enhancement of daidzein and genistein in a green okara extract. J. Science Food Agriculture, 101(12):5124-5131
• Teng TS, Chin YL, Chai KF, Chen W* (2021). Fermentation for future food systems. EMBO Reports, 22(5):e52680
• Cui X, Lee J, Ng KR, Chen W* (2021) Food waste Durian rind-derived cellulose organohydrogels: toward anti-freezing and antimicrobial wound dressing. ACS Sustainable Chem. Eng. 9, 3, 1304–1312 (IF: 7.6)
• Tan YX, Mok WK, Chen W* (2021). In Vitro Evaluation of Enriched Brewers' Spent Grains Using Bacillus subtilis WX-17 as Potential Functional Food Ingredients. Appl. Biochem. Biotechnol. 193(2): 349-362 (IF: 1.6)
• Tan YN, Zhang JH and Chen W* (2020) GC-MS-Based Metabolomics Analysis of Prawn Shell Waste Co-Fermentation by Lactobacillus plantarum and Bacillus subtilis. Polysaccharides 1, 31–50
• Rocha-Pizana M, Chen W*, Lee J, Buitimea-Cantua NE, Gonzalez-Nimi E,   Gutierrez-Uribe J (2020) Production of a potential collagenolytic protease by nejayote fermentation with Aspergillus oryzae. International Journal of Food Science and Technology, 55, 3289–3296 (IF: 2.8)
• Tan YX, Mok WK, Chen W* (2020). Potential novel nutritional beverage using submerged fermentation with Bacillus subtilis WX-17 on brewers' spent grains. Heliyon. 6(6): e04155
• Chai KF, Voo AYH, and Chen W* (2020). Bioactive peptides from food fermentation: A comprehensive review of their sources, bioactivities, applications, and future development. Comprehensive Reviews in Food Science and Food Safety, 19(6), 3825-85
• Tan YN, Lee PP, Chen W* (2020). Dual Extraction of Crustacean and Fungal Chitosan from a Single Mucor circinelloides fermentation. Fermentation, 6, 40
• Tan YX, Mok WK, Chen W* (2020) Technology innovations for food security in Singapore: a case study of future food systems for an increasingly natural resource-scarce world. Trends in Food Science & Technology, 102, 155-68.
• Gupta S, and Chen W* (2019). Characterization and in-vitro bioactivity of green extract from fermented soybean waste. ACS Omega, 4(26):21675-83
• Lyu XM, Lee J, and Chen W* (2019) Potential natural food preservatives and their sustainable production in yeast: terpenoids and polyphenols. J. Agr. Food Chem. 67(16):4397-4417 (featured on Cover Page of Journal of Agricultural and Food Chemistry Apr 24 issue 67)
• Mok WK, Tan YX, Lee J, and Chen W* (2019) A metabolomic approach to understand the solid-state fermentation of okara using Bacillus subtilis WX-17 for enhanced nutritional profile. AMB Express. 9(1):60
• Lyu XM, Zhao G, Ng KR, Mark R, and Chen W* (2019) Metabolic engineering of S. cerevisiae for de novo production of kaempferol. J. Agr. Food Chem. 67(19), 5596-606 (featured on Cover Page of Journal of Agricultural and Food Chemistry May 15 issue 67)
• Ng KR, Lyu XM, Mark R, Chen W* (2019) Antimicrobial and antioxidant activities of phenolics metabolites from flavonoid-producing yeast: potential as natural food preservatives. Food Chem. 270:123-9
• Jain A, Li XH, Chen W* (2019) Association of fecal and urine metabolites with diet or ethnicity and gut microbiome of Indian and Chinese adults: an untargeted metabolomics analysis. Scientific Reports, 9, 9191.
• Mark R, Lyu XM, Lee J, Li XH, Chen W* (2018) Sustainable production of natural phenolic food preservatives. J. Functional Foods, 57, 233-54
• Zhao G, Lee J, Cui X, Chen W* (2019) Biodegradable and transparent cellulose film prepared eco-friendly from durian rinds for packaging application. Food Packaging and Shelf Life, 21, 100345
• Lee J, Cooray S, Mark R, Chen W* (2018) Effect of sequential twin screw extrusion and fungal pretreatment to release soluble nutrients from soybean residue for carotenoids production. J. Sci. Food Agri., Nov 9. doi: 10.1002/jsfa.9476

• Kim J, Lyu XM, Lee J, Zhao G, Fong CS, Yang L*, Chen W* (2018) Metabolomics Analysis and Algicidal activity of Pseudomonas chlororaphis JK12 Under Aerobic and Micro-aerobic Culture Condition. AMB Express, 8(1):131

• Qin L, Liu L, Wang Z, Chen W, Wei D (2018) Synergistic effects in the mixed culture of microalgae Chlorella p. and yeast Y. lipolytica for microbial biomass production: with a wider perspective. Bioresource Tech. 264:90-97

• Lee J*, Zhao G, Kim J, Castillo-Zacarias C, Parra R, Chen W* (2018) Dual use of a biopolymer from durian (durio zibethinus) seed as a nutrient source and stabilizer for spray dried Lactobacillus plantarum. Frontiers in Sustainable Food Systems, https://doi.org/10.3389/fsufs.2018.00053
• Qin L, Liu L, Wang Z, Chen W, Wei D (2018) Efficient resource recycling from liquid digestate by microalgae-yeast mixed culture and the assessment of key gene transcription related to nitrogen assimilation in microalgae. Bioresource Tech. 18;264:90-97

• Jain A, Li XH, Chen W*. (2018). Similarities and differences in gut microbiome composition correlate with dietary patterns of Indian and Chinese adult. AMB Express, 8, 104.
• Gupta S, Lee J, Chen W*. (2018). An analysis of improved nutritional composition of potential functional food (okara) after probiotic solid-state fermentation. J. Agr. Food Chem. 66(21), 5373-81.
• Jain A, Chen W* (2018) Involvement of organic acids and amino acids in ameliorating Ni(II) toxicity induced cell cycle dysregulation in Caulobacter crescentus: a metabolomics analysis. Appl. Microbiol. Biotechnol., 102(10):4563-4575
• Cooray S, Chen W* (2018) Valorization of brewer's spent grain using fungi solid-state fermentation to enhance nutritional value. J. Functional Foods,42, 85-94
• Lyu XM, Lee JL, Chen W* (2017) Comparative metabolic profiling of engineered Saccharomyces cerevisiae with enhanced flavonoids production. J. Functional Foods, 44, 274-282.
• Lee JL, Lyu XM, Kim JJ, Chen W* (2017) Bioconversion of waste cooking oil into high value carotenoids and fatty acids using R. toruloides. Food Bioproducts Processing, submitted
• Mark R, Lyu XM, Ng KR, Chen W* (2017) Optimization of naringenin production in S. cerevisiae based on 4-coumarate:coenzyme (CoA) ligase and chalcone synthase gene source selection. Phytochem., revised
• Lyu XM, Ng KR, Lee JL, Mark R, and Chen W* (2017) Enhancement of naringenin biosynthesis from tyrosine by metabolic engineering of S. cerevisiae. J. Agr. Food Chem. 65: 6638-46
• Zhao GL, Chen W* (2017) Design of poly(vinylidene fluoride)-g-p(hydroxyethyl methacrylate-co-N-isopropylacrylamide) membrane via surface modification for enhanced fouling resistance and release property. Applied Surface Science, 398: 103-115
• Esquivel-Hernández DA, Rodríguez-Rodríguez J, Cuéllar-Bermúdez SP, García-Pérez S, Mancera-Andrade EI, Núñez-Echevarría JE, Ontiveros-Valencia A, Rostro-Alanis M, García-García RM, Torres A, Chen W, Parra-Saldívar R* (2017) Effect of supercritical carbon dioxide extraction parameters on the biological activities and metabolites present in extracts from Arthrospira platensis. Marine Drugs, 15, 174
• Zhao GL, Chen W* (2017) Biofouling formation and structure on the original and modified PVDF membranes: Role of microbial species and membrane properties. RSC Advances, 7: 37990-38000
• Tang XL,  Feng L,  Chen LW,  Chen W* (2017). Engineering Saccharomyces cerevisiae for efficient biosynthesis of fatty alcohols based on enhanced supply of free fatty acids ACS Omega, 2: 3284-90
• Cooray ST, Lee JL, Chen W* (2017) Evaluation of brewers’ spent grain as a novel media for yeast growth. AMB Express, 7:117
• Liu T, Yu YY, Chen T, Chen W* (2017) A synthetic microbial consortium of Shewanella and Bacillus for enhanced generation of bioelectricity. Biotechnol Bioeng. 114(3): 526-532
• Tao L, Xie M, Chiew GG, Wang Z, Chen W, Wang X (2016) Improving electron trans-inner membrane movements in microbial electrocatalysts. Chem Commun (Camb). 52(37):6292-5
• Chen LW, Lee JL, Chen W* (2016) The use of metabolic engineering to produce fatty acid-derived biofuel and chemicals in Saccharomyces cerevisiae: a review. AIMS Bioengineering, 3(4): 468-492.
• Liu T, Yu Y, Li D, Song H, Yan X, Chen  W* (2016) Effect of External Resistance on Biofilm Formation and Internal Resistance in Shewanella Inoculated Microbial Fuel Cells. RSC Advances,6:20317–20323
• Lee J, Chen L, Cao B and Chen W*. (2016) Engineering Rhodosporidium toruloides with a membrane transporter facilitates production and separation of carotenoids and lipids in a bi-phasic culture.Appl. Microbiol. Biotechnol.100(2):869-77

• Tao L, Wang H, Xie M, Thia L, Chen W, Wang X. (2015) Improving mediated electron transport in anodic bioelectrocatalysis. Chem Commun (Camb). 51(61):12170-3
• Zhao G, and Chen W*. (2015) Enhanced PVDF membrane performance via surface modification by functional polymer poly(N-isopropylacrylamide) to control protein adsorption and bacteria adhesion.Reactive and Functional Polymers, 97:19-29
• Chen L, Lee J, Zhang JH, and Chen W*. (2016) Comparative proteomic analysis of engineered Saccharomyces cerevisiae with enhanced free fatty acid accumulation. Appl. Microbiol. Biotechnol.100(3):1407-20
• Tan KY, Tang XL, and Chen W*. (2014) Expression of a heterogeneous malonyl-CoA synthetase in Saccharomyces cerevisiae and the impact of the enzyme on the overall production of fatty acids.under review
• Chan KS, Zhang JH, Tan TL, and Chen W*. (2014) Alkane intermediate molecules production catalyzed by acyl-CoA reductase and aldehyde decarbonylase in Escherichia coli. under review
• Tang XL, Lee J, and Chen W*. (2015) Engineering the fatty acid metabolic pathway in Saccharomyces cerevisiae for advanced biofuel production. Metabolic Engineering Communications 2: 58-66
• Feng HX, Zhou Y, Zhao G, Lee J, Ng WJ* and Chen W*. (2015) Comprehensive profiling of biological processes of wastewater treatment: potential for monitoring bioprocesses in wastewater treatment. J. Anal. Bioanal. Tech. 6: 3, doi: 10.4172/2155-9872.1000241
• Tao L, Wang H, Xie M, Thia L, Chen W, and Wang X*. (2015) Improving mediated electron transport in anodic bioelectrocatalysis. Chem. Commun. (Camb). 51(61): 12170-3
• Shi JH, Chen LW, and Chen W*. (2014) Comparative metabolic profiling of yeast strains during different growth phases in lipid production. under review
• Ganda L, Zhou Y, Liu Y, Chen W and Ng WJ. (2014) Metabolic behavior of denitrifying poly-phosphate accumulating organisms in the presence of coexisting free nitrous acid and carbon substrate.under review
• Zhang JH, Chen LW, Tang XL and Chen W*. (2014) Engineering transporter for biofuels in S. cerevisiae. under review
• Lee J, Chen LW, Shi JH, Trzcinski A, and Chen W*. (2014) Metabolomic profiling of Rhodosporidium toruloides grown on glycerol for carotenoids production during different growth phases. J. Agr. Food Chem. 62(41):10203-9 (IF 3.1)
• Sadrolodabaee L, Low TK, and Chen W*. (2014) Role of HBV replication in host cell metabolism: a metabolomics analysis. under review
• Tan JYL, Habib N, Chuah YW, Yau YH, Shochat SG, and Chen W*. (2015) Identification of cellular targets of microRNA-181a in HepG2 cells: a new approach for functional analysis of microRNAs.PLoS ONE, 10(4):e0123167. doi: 10.1371/journal.pone.0123167
• Chen L, and Chen W*. (2014). Metabolite and Fatty Acid Analysis of Yeast Cells and Culture Supernatants. Bio-protocol 4(17): e1219. http://www.bio-protocol.org/e1219
• Lee JH, Tang XL, and Chen W*. (2014) Increased production of medium chain fatty acid through heterologous expression of thioesterase II in S. cerevisiae. under review
• Tang XL, Tan KY, and Chen W*. (2014) Proteomics and Metabolomics Study of Saccharomyces cerevisiae Cultured under Reduced Nitrogen Condition. PLoS ONE, in press
• Zhang Y, Ng SS, Wang Y, Feng H, Chen W, Chan-Park MB, Li C, Chan V (2014). Collective cell traction force analysis on aligned smooth muscle cell sheet between three-dimensional microwalls.Interface Focus 4(2):20130056 (IF 3.1)
• Tang XL, and Chen W* (2015). Enhanced Production of Fatty Alcohols by Engineering the TAGs Synthesis Pathway in Saccharomyces cerevisiae. Biotechnol. Bioeng., 112(2):386-92 (IF 4.2) (invited to be part of the Video Highlights of the journal)
• Li X and Chen W*. (2013) Metabolic engineering yeast cells for medium chain biofuel precursor biosynthesis. Appl Microbiol. Biotechnol. Express, in press
• Zhang Y, Ng SS, He T, Fang N, Neoh KG, Kang ET, Chen W, Chan V (2014). Effect of adhesive ligand on cell deadhesion kinetics on poly(N-isopropylacrylamide). Biomed Mater Eng. 24(2):1433-45.
• Tang XL, and Chen W* (2014). Investigation of Fatty Acid Accumulation in Engineered Saccharomyces cerevisiae under Nitrogen Limited Culture Condition. Bioresource Technol., 162:200-6(IF 5.0)
• Chen LW, Lee JH, Zhang JH, and Chen W*. (2014) Enhancement of free fatty Acids production in S. cerevisiae by control of fatty acyl-CoA metabolism. Appl Microbiol Biotechnol., 98(15):6739-50 (IF 3.8)
• Feng HX, Li X, Chan V, and Chen W*. (2014) Proteomics based identification of cell migration related proteins in HBV replicating HepG2 cells. PLoS ONE,9(4):e95621 (IF 4.4)
• Chen LW, Zhang JH, and Chen W*. (2014) Engineering the Saccharomyces cerevisiae β-Oxidation Pathway to Increase Medium Chain Fatty Acid Production as Potential Biofuel. PLoS ONE,9(1):e84853.(IF 4.4)
• Mohanty A, Kathawala MH, Zhang JH, Chen W, Loo J, Kjelleberg S, Yang L, and Cao B (2014). Biogenic Tellurium Nanorods as a Novel Antivirulence Agent Inhibiting Pyoverdine Production in Pseudomonas aeruginosa. Biotechnol Bioeng, 111(5):858-65.(IF 4.2)
• Tang XL, Feng HX, Zhang JH, and Chen W* (2014). Comparative Proteomics Analysis of Engineered Saccharomyces cerevisiae with Enhanced Biofuel Precursor Production. PLoS ONE, 8(12):e84661 (IF 4.4)
• Shi JH, Feng HX, Lee JH and Chen W*. (2013) Comparative proteomics profile of different yeast strains for lipid accumulation mechanism: an analysis by iTRAQ-coupled 2-D LC-MS/MS. PLoS ONE,8(12): e85532(IF 4.4)
• Tan J and Chen W*. (2014) microRNAs as Therapeutic Strategy for HBV-associated HCC: Current Status and Future Prospects. (invited review) World J. Hepatology 20(20):5973-86 (IF 2.5)
• Tan KY and Chen W*. (2013) Malonate uptake and metabolism in S. cerevisiae. Applied Biochem. Biotech., 171(1):44-62 (IF 2.0)
• Sadrolodabaee L, Low TK, Feng HX, and Chen W*. (2013) Role of HBV replication in host cell metabolism: a proteomics Analysis. Current Proteomics, in press (IF 3.2)
• Zhang JH, Shi JH, Lee BJH, Chen LW, Tan KY, Tang XL, Tan JYL, Li X, Feng HX, and Chen W* (2013). Protocol of comparative proteomics analysis of A7r5 cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS. Methods in Molecular Biology. Humana Press, NJ, USA. 1000:45-52
• Tang XL, Feng HX, and Chen W*. (2013) Metabolic engineering for enhanced fatty acids synthesis in S. cerevisiae. Metabolic Engineering, 16C:95-102 (IF 8.3)
• Tan JYL, Habib N, and Chen W*. (2013) A quantitative proteomics approach in the study of microRNA 181a in HepG2 cells. Current Proteomics, 9:262-271(IF 3.2)
• Tang XL, Lee JH, and Chen W*. (2012) LC-MS based proteomic analysis for biofuel production. in Liquid Chromatography: Principles, Technology and Applications. Nova Science Publishers, USA. in press
• Xu JL, Joguet D, Cizek J, Khor KA, Liao HL, Coddet C and Chen W. (2012) Synthesis and characterization on atomphospheric plasma sprayed amorphous silica doped hydrxoyapatite coatings.Surface & Coatings Technology, 206: 4659-4665 (IF: 2.2)
• Zhao GL, Chen X, Wang L, Zhou SX, Feng HX, Lau R*, and Chen W*. (2012) Ultrasound assisted extraction of carbohydrates from microalgae as feedstock for yeast fermentation. Bioresource Technol., 128C:337-344 (IF 5.0)
• Bai J, Sadrolodabaee L and Chen W*. (2012) Recent Pharmacoproteomics Studies of Warfarin in the Asia-Pacific: A New Strategy for Personalized Medicine? Current Pharmacogenomics and Personalized Medicine, 10:322-331
• Zhou Y and Chen W*. (2012) Molecular mechanism of antimicrobial peptides: a proteomics perspective. in Antimicrobial Activity of Lactoferrin and Lactoferrin Derived Peptides. Nova Science Publishers, USA. in press
• Feng XS, Ching CB and Chen W*. (2012) EBV upregulates cytochrome C through VDAC1 regulations and decreases the release of cytoplasmic Ca2+ in the NPC cell line. Cell Biol. Intl., 36(8):733-8 (IF 1.8)
• Feng HX, Zhang JH, Tan J, Sadrolodabaee L and Chen W*. (2012) Proteomics-related Biomarkers for Hepatitis B Virus-Associated Hepatocellular Carcinoma: Current Status and Future Prospects.Future Virology, 7(2):161-71 (IF 1.2)
• Yuan J, Gao H, Sun J, Duan H, Chen W, Ching CB. (2012) Cytotoxicity evaluation of oxidized single-walled carbon nanotubes and graphene oxide on human hepatoma HepG2 cells: An iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicol Sci. 126(1):149-61 (IF 5.3)
• Zhang JH and Chen W*. (2012) Inhibitory Effects of NASIAD Drug Ibuprofen on HBx-induced Angiogenesis. Interventional Medicine & Applied Science, 4 (1): 21–31
• Zhou Y and Chen W*. (2011) iTRAQ-coupled 2-D LC-MS/MS Analysis of Cytoplasmic Protein Profile in Escherichia coli Incubated with Apidaecin IB. J. Proteomics, 75(2):511-6 (IF 5.1)
• Loh L, Yu H, Lau WM and Chen W*. (2011) Efficient DNA transformation of microalgae by electroporation. submitted.
• Zhou Y and Chen W*. (2011) iTRAQ-coupled 2-D LC-MS/MS Analysis of Membrane Protein Profile in Escherichia coli Incubated with Apidaecin IB. PLoS ONE, 6(6):e20442 (IF 4.4)
• Chen X, Goh QR, Tan WF, Hossain MI, Chen W and Lau R. (2011) Lumostatic strategy for microalgae cultivation utilizing image analysis and chlorophyll-a content as design parameter. Bioresource Technol., 102(10):6005-12(IF 5.0)
• Li X, Feng HX, Chen W* and Chan V*. (2011) Epigallocatechin-3-gallate (EGCG) Induced Modulation of Cell Adhesion, Deadhesion and Migration. J Biomed Mater Res A, 98(3):450-60 (IF 3.0)
• Feng XS, Zhang JH, Chen W*, and Ching CB. (2011) Proteome profiling of Epstein-Barr virus infected nasopharyngeal carcinoma cell line: a comparative iTRAQ-coupled 2D LC/MS-MS analysis. J. Proteomics, 74(4):567-76 (IF 5.1)
• Feng XS, Chowbay B, Chen W* and Ching CB. (2011) iTRAQ-coupled 2-D LC-MS/MS Analysis of Differentially Expressed Serum Proteins in Nasopharyngeal Carcinoma Clinical Samples: Potential in Biomarker Discovery. JMIHI, in press
• Lee JH, Zhou YS, Wang MX and Chen W*. (2011) Inhibitory effect of Bovine lactoferrin on human hepatitis B virus expression in HepG 2.2.15 cell line. BIO, in press
• Rasouliha BH, Zhou YS and Chen W*. (2011) iTRAQ-coupled 2D LC-MS/MS Analysis of Protein Profile in MCF-7 Human Breast Cancer Cells Incubated with Doxorubicin: potential role of Heat Shock Protein 90. revised
• Rasouliha BH, Zhou YS, Chowbay B and Chen W*. (2011) iTRAQ-coupled LC-MS/MS Analysis of Serum Protein Profile in Asian Breast Cancer Patients: Insight on Correlation between MDM2 SNP309 Genotypes and Resistance to Doxorubicin Therapy. JMIHI, in press
• Yuan J, Gao H, Sui J, Chen W, Ching CB. (2011) Cytotoxicity of single-walled carbon nanotubes on human hepatoma HepG2 cells: an iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicol In Vitro. 25(8):1820-7. (IF 3.2)
• Basu A, Chen W and Leong SSJ. (2011) A rational design for hepatitis B virus X protein refolding and bioprocess development guided by second virial coefficient studies. Appl. Microbiol. Biotechnol.,90(1):181-91 (IF 3.3)
• Bai J, Wang MX, Chowbay B, Ching CB and Chen W*. (2011) Metabolic Profiling of HepG2 Cells Incubated with S- and R-enantiomers of Anti-coagulating Drug Warfarin. Metabolomics, 7(3): 353-362 (IF 4.5)
• Fen HX, Li X, Niu DD and Chen W*. (2011) HBV replication activates RhoA GTPase: impact on cell migration. Cell Biol. Intl., 2(6): 159-64 (IF 1.8)
• Saminathan R, Bai J, Sadrolodabaee L, Karthik GM, Singh O, Subramaniyan K, Ching CB, Chen W* and Chowbay B* (2010) Warfarin Pharmacogenetics and Pharmacoproteomics In Asian Patients Receiving Anticoagulant Therapy: transthyretin precursor as potential biomarker. PLoS ONE, 5(12):e15064 (IF 4.4)
• Niu DD, Zhang JH, Feng HX and Chen W*. (2010) DLEC1 Expression Is Modulated by Epigenetic Modifications in Hepatocelluar Carcinoma Cells: Role of HBx Genotypes. Cancers, 2(3), 1689-1704
• Wang MX, Bai J, Chen W*, and Ching CB. (2010) Metabolic Profiling of Cellular Responses to Carvedilol Enantiomers in Vascular Smooth Muscle Cells. PLoS ONE,5(11):e15441(IF 4.4)
• Bai J, Sadrolodabaee L, Chowbay B and Chen W*. (2010) Secreted Protein Profile Analysis on HepG2 cells Incubated by S(-) and R(+) Enantiomers of Chiral Drug Warfarin. Proteomics – Clin. Appl. 4(10-11), 808-15 (IF 2.9)
• Feng HX, Wang MX and Chen W*. (2010) iTRAQ-coupled 2D LC-MS/MS analysis of secreted proteome from HBV-replicating HepG2 cells. Curr. Microbiol. 61(4), 280-4(IF 1.8)
• Zhou YS, Leong SS, Chan-Park MB, Chang MW, Mouad L and Chen W*. (2010) iTRAQ-coupled 2-D LC-MS/MS analysis on protein profile in Escherichia coli cells incubated with human neutrophil peptide 1. Rapid Commun. Mass Spec. 24(18):2787-90 (IF 2.8)
• Qi X, Zhou C, Li P, Xu W, Cao Y, Ling H, Chen W, Ming Li C, Xu R, Lamrani M, Mu Y, Leong SS, Wook Chang M, Chan-Park MB. (2010) Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms.Biochem. Biophys. Res. Commun., 398(3):594-600 (IF 2.6)
• Sui JJ, Wang MX, Zhang JJ, Ching CB and Chen W*. (2010) Enhanced secretion of T-kininogen by vascular smooth muscle cells in response to S-enantiomer of atenolol. Rapid Commun. Mass Spec.24(11):1717-9 (IF 2.8)
• Wang MX, Wang XJ, Ching CB and Chen W*. (2010) Protein profile in Vascular Smooth Muscle Cells Incubated with S- and R-enantiomers of Carvedilol Using iTRAQ-coupled 2-D LC-MS/MS: Possible Action of Induced Proteins Involved in Inhibitory Effect of Carvedilol on Calcium Channels. J. Proteomics, 73(8): 1601-11. (IF 5.1)
• Lal S, Mahajan A, Chen W, Chowbay B. (2010) Pharmacogenetics of Target Genes Across Doxorubicin Disposition Pathway: A Review. Curr. Drug Metab. 11(1):115-28 (IF 3.9)
• Niu DD, Feng HX, and Chen W*. (2010) Proteomics of hepatitis: insights in liver diseases and prognostics biomarkers. J. Proteomics, 73: 1283-1290 (IF 5.1)
• Bai J, Sadrolodabaee L, Ching CB, Chowbay B and Chen W*. (2010) A Comparative Proteomic Analysis of HepG2 Cells Incubated with S(-) and R(+) Enantiomers of Anti-coagulating Drug Warfarin.Proteomics, 10:1463-1473 (IF 4.8)
• Feng HX, Li X, Niu DD and Chen W*. (2010) Protein Profile in HBx Transfected Cells: a Comparative iTRAQ-coupled 2D LC-MS/MS Analysis. J. Proteomics, 73(8): 1421-32. (IF 5.1)
• Ching CB*, Zhang JH, Sui JJ and Chen W*. (2010) Comparative LC-MS analysis of proteomics profile of cells in response to incubation with S- or R-enantiomers of chiral drugs. Proteomics, 10(4):888-93 (IF 4.8)
• Li X, Feng HX, Chen W* and Chan V*. (2010) HBV replication induces coupling of deadhesion and migration of HepG2 cells on the thermo-responsive polymer. Biomaterials, 31:1894-903 (IF 8.3)
• Zhou C, Qi X, Li P, Chen W, Mouad L, Chang MW, Leong SS, Chan-Park MB. (2010) High Potency and Broad-Spectrum Antimicrobial Peptides Synthesized via Ring-Opening Polymerization of alpha-Aminoacid-N-carboxyanhydrides. Biomacromolecules, 11:60-7 (IF 5.3)
• Feng HX, Tan TL, Niu DD and Chen W*. (2010) Hepatitis B virus X protein interacts with cytoskeletal signaling proteins through SH3 binding. Front. Biosci. E2:143-150 (IF 4.0)
• Feng Z, Chen B, Tang SC, Liao K, Chen W and Chan V. (2010) Effect of Cytoskeleton Inhibitors on Deadhesion Kinetics of HepG2 Cells on Biomimetic Surface. Colloids and Surfaces B: Biointerfaces, 75(1):67-74 (IF 2.9)
• Feng HX, Zhang JH, Li X and Chen W*. (2009) Migration of HBV-replicating HepG2 cells mediated by HBX: insights on development of hepatocellular carcinoma. J. Biomed. Biotechnol. 2009:930268 (IF 2.7)
• Xu JL, Khor KA, Sui JJ, Zhang JH and Chen W*. (2009) Proteins and gene expression changes in osteoblasts oesponse to hydroxyapatite nanoparticles. Biomaterials, 30(29):5385-91 (IF 8.3)
• Niu DD, Sui JJ, Zhang JH, Feng HX and Chen W*. (2009) iTRAQ-coupled 2D LC-MS/MS analysis of cellular protein profile with aberrant HBV-modulated DNA methylation: implications in hepatocarcinogenesis. Proteomics, 9(15):3856-3868 (IF 4.8) (featured on Cover Page of Proteomics Aug issue 15)
• Sui JJ, Zhang JH, Ching CB and Chen W*. (2009) Expanding proteomics into chiralities of chiral drugs. Molecular BioSystems, 5:603-608 (IF 4.2)
• Niu DD, Zhang JH, Ren YD, Feng HX and Chen W*. (2009) HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells. Molecular Oncology, 3(1): 67-76 (IF 6.7)
• Zhang JH, Niu DD, Sui JJ, Ching CB and Chen W*. (2009) Protein profile in HBV replicating rat primary hepatocytes and HepG2 cells by iTRAQ-coupled 2D LC-MS/MS analysis: insights on liver angiogenesis. Proteomics, 9: 2836-2845 (IF 4.8)
• Xu JL, Khor KA, Sui JJ, Chen W. (2009) Preparation and characterization of a novel hydroxyapatite/carbon nanotubes composite and its interaction with osteoblast-like cells. Materials Science and Engineering C, 29(1): 44-49 (IF 2.2)
• Sui JJ, Zhang JH, Ching CB and Chen W*. (2008) Comparative proteomic analysis of extracellular proteins revealed secretion of T-kininogen from vascular smooth muscle cells in response to incubation with S-enantiomer of propranolol. Mol. Pharmaceutics, 5(5): 885-890 (IF 5.4)
• Xu JL, Khor KA, Sui JJ and Chen W. (2008) Investigation of multiwall carbon nanotube modified hydroxyapatite on human osteoblast cell line using iTRAQ proteomics technology. Key Engineering Materials 361-363:1047-1050
• Lu YW, Ren YD, Bai J and Chen W*. (2008) The BH3-containing HBSP, a spliced variant apoptotic hepatitis B viral protein, interacts with cellular anti-apoptotic proteins. IUBMB Life, 60(10): 700-702 (IF 4.3)
• Xu JL*, Khor KA, Sui JJ, Zhang JH, Tan TL, Chen W*. (2008) A proteomics study of osteoblasts on hydroxyapatite based biomaterials using isobaric tagging for relative and absolute quantification technology. Proteomics, 8( 20): 4249-4258 (IF 4.8)
• Sui J, Zhang J, Tan TL, Ching CB and Chen W*. (2008) iTRAQ-coupled 2D LC-MS/MS Analysis on Protein Profile in Vascular Smooth Muscle Cells Incubated with S- and R-enantiomers of Atenolol: possible role of Ca ++-binding proteins. Mol. Cell. Proteomics, 7(6):1007-1018 (IF 8.8)
• Xu JL*, Khor KA, Sui JJ, Chen W. (2008) Investigation of multiwall carbon nanotube modified hydroxyapatite on human osteoblast cell line using iTRAQ proteomics technology. Bioceramics, 20:361-3
• Zhang JH, Sui JJ, Ching CB and Chen W*. (2008) Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ LC-MS/MS analysis: possible action of induced proteins on Alzheimer disease. Proteomics, 8: 1595-1607. (IF 4.8) (featured in Proteomics podcast April 2008 and available athttp://www3.interscience.wiley.com/journal/76510741/home/2120_pod.html)
• Leong SSJ and Chen W. (2008) Preparing recombinant single chain monoclonal antibodies. (Review) Chem. Eng. Sci. 63:1401-1414 (IF 2.6)
• Xu JL, Khor KA, Lu YW, Chen W, and Kumar R. (2008) Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique. J Biomed Mater Res B, 84: 224-30 (IF 2.2)
• Chen B, Xu FJ, Neoh KG, Kang ET, Chen W and Chan V. (2008) Engineering cell de-adhesion dynamics on thermo-responsive Poly(N-isopropylacrylamide). Acta Biomaterialia, 4:218-229 (IF 5.7)
• Tan TL, Fang N, Neo TL, Singh P, Zhou RJ, Zhang JH, Koh CG, Chan V, Lim SG and Chen W*. (2008) Rac1 GTPase is activated by hepatitis B virus replication – involvement of HBX. Biochim. Biophys. Acta – Mol. Cell Res. 1783: 360-374 (IF 5.3)
• Lu YW and Chen W*. (2007) Cellular apoptosis induced by hepatitis B virus replication: association with viral genotypes. Virol. J. 4: 117 (IF 2.5)
• Pan H, Niu DD, Feng HX, Ng FP, Ren EC and Chen W*. (2007) Identification of cellular transcription factors that bind to hepatitis B virus core promoter with naturally occurring deletions, and analysis of their impact on viral replication. Biochim. Biophys. Acta – Mol. Basis Dis. 1772:1075-84 (IF 5.2)
• Sui JJ, Tan TL, Zhang JH, Ching CB and Chen W*. (2007) iTRAQ-coupled 2D LC-MS/MS analysis on protein profile in vascular smooth muscle cells treated with S- and R-enantiomers of propranolol: possible role of metabolic enzymes involved in cellular anabolism. J. Proteome Res., 6:1643-51 (IF 5.7)
• Xu JL, Khor KA and Chen W. (2007) A study of osteocalcin production in vitro on various hydroxyapatite based biomaterials. Key Engineering Materials 330-332: 897-900
• Chen B, Dang J, Tan TL, Chen W, Leong KW and Chan V. (2007) Dynamics of smooth muscle cell de-adhesion from thermosensitive hydroxybutyl chitosan. Biomaterials, 28: 1503-1514. (IF 7.9)
• Li H, Khor KA, Chen W, Tan TL, Pan H, Cheang P. (2007) Proteomics Study of the Osteoblast Cells Proliferated on Nanostructured Hydroxyapartite Coatings. Key Engineering Materials 330-332: 381-384.
• Lu YW, Chan V and Chen W*. (2006) The HBSP gene is expressed during HBV replication, and its coded BH3-containing spliced viral protein induces apoptosis in HepG2 cells . Biochem. Biophys. Res. Commun., 351: 64-70 (IF 2.6)
• Shen JY, Chan-Park MB, He B, Zhu AP, Zhu X, Beuerman RW, Yang EB, Chen W, and Chan V. (2006) Three-Dimensional Microchannels in Biodegradable Polymeric Films for Control Orientation and Phenotype of Vascular Smooth Muscle Cells. Tissue Engineering, 12:2229-40 (IF 4.7)  
• Tan TL, Feng Z, Lu YW, Chan V and Chen W*. (2006). Adhesion contact kinetics of HepG2 cells during hepatitis B virus replication: involvement of SH3-binding motif in HBX. Biochim. Biophys. Acta – Mol. Basis Dis., 1762: 755-66 (IF 5.2)
• Yang EB, Wei L, Zhang K, Chen YZ and Chen W. (2006) Tannic acid, a potent inhibitor of epidermal growth factor receptor tyrosine kinase. J. Biochem. 139: 495-502. (IF 2.1)
• Lu YW and Chen W*. (2005) Molecular mechanism of pro-apoptotic activity by human hepatitis B virus X protein: the role of the BH3 domain. Biochem. Biophys. Res. Commun. 338: 1551-1556 (IF 2.6)
• Lwa SH and Chen W*. (2005) Hepatitis B virus X protein interacts with beta5 subunit of heterotrimeric guanine nucleotide binding protein. Virol. J. 2: 76 (IF 2.5)
• Ng F-P, Chan M, Cheng P, Leung HE, Chan S, Chen W and Ren EC. (2005) The heterogeneous ribonucleoprotein K (hnRNPK) is a regulatory component in hepatitis B virus replication. PLoS Medicine 2(7): 163. 2005 (IF 15.3) (highlighted in Editorial Commentary available at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1181893)
• Toh QC , Tan TL, Teo WQ, Ho CY, Parida S and Chen W*. (2005). Identification of cellular membrane proteins interacting with hepatitis B surface antigen using yeast split-ubiquitin system. Intl. J. Med. Sci. 2: 114-117 (IF 2.4)
• Pan H, Ng L, Ren EC and Chen W*. (2005) A cell-based system for hepatitis B virus replication: significance of clinically enhanced viral replication in relation to deletions in viral core promoter. Front. Biosci. 10: 2001-2004 (IF 4.2)
• Feng Z, Chen W, Liao K and Chan V. (2005) GFP-actin expression modulates the adhesion dynamics of HepG2 cells on model extracellular matrix. Biomaterials, 26: 5348-5358 (IF 8.3)
• Tan TL and Chen W*. (2005) A proteomics analysis of cellular proteins associated with HBV genotype specific HBX: potential in identification of early diagnostic markers for HCC. J. Clin. Virol. 33: 293-298 (IF 4.0)
• Oon CJ and Chen W*. (2003) Lymphoblastoid a -interferon in the prevention of hepatocellular carcinoma (HCC) in high risk HBsAg positive resected cirrhotic HCC cases: a 13-year follow up. Cancer Invest. 21(3): 394-399 (IF 2.0)
• Chen W*, Oon CJ and Lim GK. (2002) Hepatitis B Virus Surface Antigen Mutants Persist in Singapore Chronic Carriers Receiving Lamivudine Therapy. J. Antimicrob. Chemother. 49 (6): 1044-1046 (IF 4.7)
• Chen W* and Oon CJ. (2002) Heptitis B virus mutants: an overview. J. Gastroenterol. Hepatol. 17, 497-499 (IF 3.6) 
• Oon CJ, Chen W*, Goh KT, Mesenas S, Ng HS, Chiang G, Tan C, Koh S, Teng SW, Toh I, Moh MC, Goo KS, Tan K, Leong AL, and Tan GS. (2002) Molecular characterization of hepatitis B virus surface antigen mutants in Singapore patients with hepatocellular carcinoma and HBV carriers negative for HBsAg, but positive for anti-HBs and anti-HBc. J. Gastroenterol. Hepatol. 17, 491-496 (IF 3.6) 
• Chen W* and Oon CJ. (2002) Pre-S deletion mutants co-exist with wild-type virus at low viral replication stage in Singapore chronic hepatitis B virus carriers. Current Microbiol. 44: 145-147 (IF 1.8)
• Chen W* and Oon CJ. Functional analysis of hepatitis B virus X variants that are integrated and expressed in human hepatocellular carcinomas (2002), In: SchinaziRF, Rice C and Sommadossi JP ( eds) Frontiers in Viral Hepatitis. Elsevier Science, The Netherlands, Chap 40: 503-511
• Chen W*, Oon CJ and Lim GK. (2001) Frequent occurrence of hepatitis B virus surface antigen mutants in subtype adw in vaccinated Singapore infants. Vaccine 20: 639-640 (IF 3.6)    
• Chen W*, Goo KS and Oon CJ. (2001) Hepatitis B virus X protein in the proteasome of mammalian cells: defining the targeting domain. Mol. Biol. Rep. 28(1): 31-34 (IF 2.9)          
• Oon CJ and Chen W*. (2001) Defense of blood supplies. Med. Progress 28(7): 105-108
• Oon CJ and Chen W*. (2001) Hepatitis B virus surface antigen mutants and their significance. Med. Progress 28(7): 85-88
• Chen W* , Oon CJ, Leong AL, Koh S and Teng SW. (2000) Expression of integrated hepatitis B virus X variants in human hepatocellular carcinomas and its significance. Biochem. Biophys. Res. Commun. 276: 885-892 (IF 2.6)
• Oon CJ, Chen W*, Goo KS and Goh KT. (2000) Horizontal transmission of vaccine escape hepatitis B virus surface antigen mutant Gly145Arg: an intrafamilial analysis. J. Infect. 41: 260-264 (IF 3.8)
• Oon CJ, Goh KT, Tan KL and Chen W. (2000) Changing trends in hepatitis B carrier state, acute morbidity and primary liver cancer rates following mass hepatitis B vaccination with low doses vaccines appearances of HBV surface mutants. J. Gastroenterol. Hepatol. 15: S1103 (IF 3.6)
• Chen W* and Oon CJ. (2000) Mutations and deletions in core promoter, and precore stop codon in relation to viral replication and liver damage in Singapore hepatitis B virus carriers. Eur. J. Clin. Invest. 30: 787-792. (IF 2.8) (highlighted in Editorial Commentary in Eur J Clin Invest. 2000 Sep;30(9):751-3)
• Chen W* and Oon CJ. (2000) Hepatitis B virus surface antigen mutants in Singapore adults and vaccinated infants with high anti-HBs levels but negative for surface antigen. J. Clin. Microbiol. 38(7): 2793-2794 (IF 4.2)
• Chen W* , Oon CJ and Toh I. (2000) Altered antigenicities of hepatitis B virus surface antigen carrying mutations outside the common ‘a’ determinant. Am. J. Gastroenterol. 95(4): 1098-1099 (IF 9.2)           
• Chen W*. (2000) Hepatitis B virus surface antigen mutants cause emerging concern. (news) Lancet 355 (9206): 812 (IF 28.4)
• Chen W*, Oon CJ and Moh MC. (2000) Detection of hepatitis B surface antigen mutants in paraffin-embedded hepatocellular carcinoma tissues. Virus Genes 20(3): 263-267 (IF 1.7)          
• Chen W* and Oon CJ. (2000) Changes in antigenicity of a hepatitis B virus mutant stemming from lamivudine therapy. Antimicrob. Agents Chemother. 44 (6): 1765 (IF 4.7)           
• Chen W*, Oon CJ and Koh S. (2000) Horizontal transmission of a human hepatitis B virus surface antigen mutant. J. Clin. Microbiol. 38: 938-939 (IF 4.2)      
• Chen W* and Oon CJ. (1999) Functional analysis of hepatitis B virus X variants that are integrated and expressed in human hepatocellular carcinomas. Antiviral Therapy 4: 98 (IF 4.1)
• Chen W* and Oon CJ. (1999) Mutation ‘hot spot’ in HLA Class I-Restricted T Cell epitope on hepatitis B surface antigen in chronic carriers and hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 262: 757-761 (IF 2.6)
• Chen W* and Oon CJ. (1999) Human hepatitis B virus mutants: significance of molecular changes. (Minireview) FEBS Lett. 453: 237-242 (IF 3.5)       
• Oon CJ, Chen W, Koh S and Lim GK. (1999) Identification of hepatitis B surface antigen variants with alterations outside the ‘a’ determinant in immunized Singapore infants. J. Infect. Dis. 179(1): 259-263 (IF 6.3)
• Oon CJ, Chen W, Zhao Y, Teng SW and Leong AL. (1999) Detection of hepatitis B virus surface antigen mutants and their integration in human hepatocellular carcinoma. Cancer Lett. 136 (1): 95-99 (IF 5.0)
• Oon CJ, Chen W, Lim N, Lim GK, Koh S, Leong AL, Tan GS and Teng SW. (1999) Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the ‘a’ epitope of the surface antigen are sensitive to ganciclovir. Antiviral Res. 41(3): 113-118 (IF 4.4)
• Yap SF, Chen W and Lim L. (1999) Molecular characterization of the C. elegans Rho GDP-dissociation inhibitor. Eur. J. Biochem. 266(3): 1090-1100 (IF 3.1)
• Oon CJ and Chen W. (1998) Current aspects of hepatitis B virus surface antigen mutants in Singapore. J. Viral Hepatitis 5(2): 17-24 (IF 3.3)
• Chen W, Chen S, Yap SF and Lim L. (1996) The C. elgans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J. Biol. Chem. 271: 26362-26368 (IF 5.5)
• Chen W, Yap SF and Lim L. (1996) Isolation of the gene coding for C. elegansRac2 homologue, a Ras-related small GTP-binding protein. Gene 180: 217-219 (IF 2.6)
• Chen W* and Lim L. (1994) The C. elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development. J. Biol. Chem. 269: 32394-32404 (IF 5.5)        
• Chen W, Blanc J and Lim L. (1994) Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from C. elegans. J. Biol. Chem. 269: 820-823 (IF 5.5)
• Chen W, Lim HH and Lim L. (1993) The CDC42 homologue from C. elegans: complementation of yeast mutation. J. Biol. Chem. 268: 13280-13285 (IF 5.5)          
• Chen W, Lim HH and Lim L. (1993) A new member of the Ras superfamily, the rac1 homologue from C. elegans. J. Biol. Chem. 268: 320-324 (IF 5.5)
• Chen W, Balzi E, Capieaux E, Choder M and Goffeau A. (1991) The DNA sequencing of the 17 kb HindIII fragment spanning the Leu1 and Ate1 loci on the chromosome VII from S. cerevisiae reveals PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance. Yeast 7: 287-299 (IF 2.6)
• Chen W, Capieaux E, Balzi E and Goffeau A. (1991) The YGL021 gene encodes a putative membrane protein with a putative leucine zipper motif. Yeast 7: 301-303 (IF 2.6)
• Chen W, Capieaux E, Balzi E and Goffeau A. (1991) The YGL022 gene encodes a putative transport protein. Yeast 7: 305-308 (IF 2.6)
• Chen W, Balzi E, Capieaux E and Goffeau A. (1991) The YGL023 gene encodes a putative regulatory protein. Yeast 7: 309-312 (IF 2.6)
• Skala J, Capieaux E, Balzi E, Chen W and Goffeau A. (1991) Complete sequence of the S. cerevisiae Leu1 gene encoding isopropylmalate isomerase. Yeast 7: 281-285 (IF 2.6)         
• Balzi E, Choder M, Chen W, Varshavsky A and Goffeau A. (1990) Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of S. cerevisiae. J. Biol. Chem. 265: 7464-7471 (IF 5.5)
• Balzi E, Chen W, Capieaux E, McCuster JH, Haber JE and Goffeau A. (1989) The suppressor gene scl1 + of S. cerevisiae is essential for growth. Gene 83: 271-279 (IF 2.6)
• Chen W, Balzi E, Capieaux E and Goffeau A. (1988) Complete sequence of a 20 kb DNA segment on chromosome VII from S. cerevisiae. Yeast 4: 75 (IF 2.6)
• Balzi E, Chen W, Ulaszewski S, Capieaux E and Goffeau A. (1987) The multidrug resistance gene PDR1 from S. cerevisiae. J. Biol. Chem. 262: 16871-16879 (IF 5.5)
• Mahillon J, Chen W and Delcour J. (1985) Study of three cryptic plasmids from Bacillus thuringiensis. Arch. Intl. Physiol. Biochem. 93: 43-45

* corresponding author