TT-Lab

PhotoChemBiomed

--- Illuminating Knowledge ---

Teaching

Research

People

Publications

Administration

Jobs

Spin-off

ntu11221

 

Associate Professor Timothy Thatt Yang TAN

Associate Chair (Academic)

School of Chemical and Biomedical Engineering

Nanyang Technological University

N1.2-01-13 / N1.2-B2-34

62 Nanyang Drive, Singapore 637459

Tel: (65) 6592 1614, 6316 8829
Fax: (65) 6794 7553
Email: tytan@ntu.edu.sg
Google Scholar: Timothy T.Y. Tan

ResearcherID: G-6223-2010

 

 

Photo-Driven Chemical and Biomedical Engineering

 

Our research is inspired by light as a sustainable energy source to drive chemical processes, and its minimal invasiveness to achieve biomedical diagnosis and therapy. Our overall theme is concerned with designing, developing and understanding new processes, and redesigning and improving existing ones, to simultaneously enhance economic value and reduce the impact on the environment, so as to advance healthcare and enable the necessary societal transformation to a sustainable future.

 

We focus on enhancing solar-enabled processes such as solar cells and solar-driven fuel production via materials architecture engineering from nano-to-micron scale to improve photoconversion efficiency and charge transport kinetics. We are also interested in the use of novel and sustainable approaches in these processes, with a strong regard to the impact on the environment and the long-term sustainability of the processes developed.

 

Our work in photo-enabled biomedical processes centers at the interface of chemical, materials and biological engineering. Our goal is to integrate useful components/processes into multifunctional systems for simultaneous diagnosis and light-triggered therapy, and to interrogate the fundamental mechanisms dictating the combinatorial performances of these processes.

 

Through the pursue of the two areas discussed above, our multidisciplinary and collaborative efforts have motivated a cross-over into other non light-mediated processes such as sustainable separation technology, bio-inspired fuel cells, tissue-inspired engineering and high performance biosensing.

 

 

News:

 

2014:

 

Congratulations to Mr Wei Wei and Dr Zhang Yan for publishing “Cross Relaxation Induced Pure Red Upconversion in Activator- and Sensitizer-Rich Lanthanide Nanoparticles” in Chemistry of Materials.

 

Congratulations to Dr Zhang Yan and Mr Wei Wei for publishing an invited review “Engineering Lanthanide-based Materials for Nanomedicine” in Journal of Photochemistry and Photobiology C: Photochemistry Reviews.

 

Congratulations to Dr He Ziming for winning the 2014 World Future Foundation (WFF) PhD Prize in Environmental and Sustainability Research for outstanding PhD thesis.

 

Congratulations to Dr Liu Jing for winning the “Chinese Government Award for Outstanding Self-Financed Students Abroad” in 2014.

 

Congratulations to Dr Liu Jing and Dr He Ziming for passing their oral defense!

 

We welcome Dr Xu Qingchi (Senior Research Fellow) to our lab.

 

2013:

 

He Ziming and Liu Jing’s work “Understanding TiO2 Size-Dependent Electron Transport Properties of a Graphene-TiO2 Photoanode in Dye-sensitized Solar Cell Using Conducting Atomic Force Microscopy” has been accepted in Advanced Materials.... Congratulations!

 

We welcome Mr Zeng Zhiping (PhD candidate) to our lab.

 

Congratulations to Dr Ai Feng and Dr Diana Vanda Wellia at the 2013 convocation!

 

Congratulations to Mr Kazi Monzure Khoda for passing his oral defense.

 

Congratulations to He Ziming for being one of the 29 recipients of “Chinese Government Award for Outstanding Self-Financed Students Abroad”. Well done!

 

We welcome Mr Wei Wei (PhD candidate) to our lab.

 

Hu Peng’s work “Ions Induced Synthesis of Uniform Single Crystalline Sulphide-based Quaternary Alloy Hexagonal Nanorings for Highly Efficient Photocatalytic Hydrogen Evolution” has been accepted in Advanced Materials.... Congratulations!

 

2012:

 

John Liu’s work “Multifunctional P(PEGMA)-REDV conjugated titanium surfaces for improved endothelial cell selectivity and hemocompatibility” has been accepted in Journal of Materials Chemistry .... Congratulations!

 

We welcome Miss Dai Yun (Project Officer) and Ms Khoo Si Yun (PhD candidate) to our lab.

 

Zhang Yan’s work “Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging” has been accepted in Chemical Communications .... Congratulations!

 

Congratulations to Ms Diana Vanda Wellia for passing her oral defense!

 

We welcome PhD students Ms Xue Jingwen and Mr Chun Yong Yao to our lab.

 

He Ziming and Liu Jing’s work “Architecture engineering of hierarchically porous chitosan/vacuum-stripped graphene scaffold as bioanode for high performance microbial fuel cell” has been accepted in Nano Letters .. Congratulations!

 

Xu Qingchi and Zhang Yan’s work “Anti-cAngptl4 Ab-conjugated N-TiO2/NaYF4:Yb,Tm Nanocomposite for Near Infrared-Triggered Drug Release and Enhanced Targeted Cancer Cell Ablation “ has been accepted in Advanced Healthcare Materials .. Congratulations!

 

Congratulations to Zhang Yan for passing her oral defense!

 

We welcome Dr Lin Jingdong to our lab as a Postdoctoral Fellow.

 

We welcome Dr John Liu to our lab as a Postdoctoral Fellow.

 

We welcome a new PhD candidate, Mr Ngaw Chee Keong, to our lab.

 

Research Highlights

 

·    Cross Relaxation Induced Pure Red Upconversion in Activator- and Sensitizer-Rich Lanthanide NanoparticlesChemistry of Materials. 2014 DOI: 10.1021/cm5022382

 

·    “Understanding TiO2 Size-Dependent Electron Transport Properties of a Graphene-TiO2 Photoanode in Dye-sensitized Solar Cell Using Conducting Atomic Force Microscopy” Advanced Materials, 2013 25 47 p6900

 

c-AFM-one layer

C-AFM dark current images of the composite electrodes based on Graphene-TiO2 of  TiO2 size (a)  12.1 nm (S1), (b) 7.8 nm (S2) and (c) 2.5 nm (S3). The scan size is 400 nm × 400 nm and the bias is −5 V applied to FTO substrate. (d) Comparison of the trend between the c-AFM average current of the three composite electrodes (dotted line) and Jsc of the three bulk devices (dashed line).

·    “Ions Induced Synthesis of Uniform Single Crystalline Sulphide-based Quaternary Alloy Hexagonal Nanorings for Highly Efficient Photocatalytic Hydrogen Evolution” Advanced Materials DOI: 10.1002/adma.201204545

 

Figure 1a-2

 

 

 

 

 

 

 

·    Architecture engineering of hierarchically porous chitosan/vacuum-stripped graphene scaffold as bioanode for high performance microbial fuel cellNano Letters 2012, 12 (9) p4738 (DOI: 10.1021/nl302175j)

 

 

 

 

 

 

 

 

 

 

·    Anti-cAngptl4 Ab-conjugated N-TiO2/NaYF4:Yb,Tm Nanocomposite for Near Infrared-Triggered Drug Release and Enhanced Targeted Cancer Cell AblationAdvanced Healthcare Materials, 2012, 1, 4, p470-474  (DOI: 10.1002/adhm.201200055)

 

Table of Contents

 

 

 

 

 

 

 

 

 

 

 

 

·    ‘HOT’ article featured on Nanoscale blog and journal homepage: http://blogs.rsc.org/nr.

Killing bacteria in broad daylight: “Understanding bactericidal performance on ambient light activated TiO2-InVO4 nanostructured films” Nanoscale, 2011, 3 (12), 4977 - 4983.

 

TOC-one layer.tif

·    Top 25 Hottest Articles in Journal of Photochemistry and Photobiology A: Chemistry from July 2010 – June 2011. “Transparent Visible Light Activated C-N-F-Codoped TiO2 Films for Self-Cleaning Applications” 2010, 210, 181-187.

 

·    Top 10 most accessed articles when published in October 2011 in Nanoscale: “Nanostructure control of graphene-composited TiO2 by a one-step solvothermal approach for high performance dye-sensitized solar cells” 2011, 3 (11), 4613 - 4616.

TOC
 

 

 

 

 

 

 

 

 

 

 

 


·    A Three-Way Synergy of Triple-Modified Bi2WO6/Ag/N-TiO2 Nanojunction Film for Enhanced Photogenerated Charges Utilization, Chem. Commun., 2011, 47 (30), 8641 - 8643

 

Scheme 1.jpg
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


·    Facile preparation of cyclodextrin chiral stationary phases via organic soluble catalytic “click” chemistry for enantioseparation of chiral drugs, Nature Protocols 2011 6 p935-942.

 

Figure 2
 

 

 

 

 

 

 

 

 

 

 

 


·    Single-Phase Dy2O3:Tb3+ Nanocrystals as Dual-Modal Contrast Agent for High Field Magnetic Resonance and Optical Imaging, Chemistry of Materials  2011, 23 (9), pp 2439–2446.

 

 

 

 

 

 

 

 

 


             

 

 

·    Our work is featured on the cover of Nanoscale, 2010, 2, 1122-1127. “Superhydrophilicity-Assisted Preparation of Transparent and Visible Light Activated N-doped Titania Film”

 

 

 

 

 

 

 

 

 

 

 

 


Education:

 

PhD (Chemical Engineering), Feb 2004 – University of New South Wales, Australia. Thesis “Photocatalytic Reduction of Selenate and Selenite: Water/Wastewater treatment and the Formation of Nano-Selenium Compounds” under the International Postgraduate Research Awards (IPRS), Australia and supervision of Professor Rose Amal.

 

B.E. (Chemical Engineering) Hon 1st Class, Feb 2000 – University of New South Wales, Australia.

 

Employment history:

 

Feb 2012 – current: Associate Professor, School of Chemical and Biomedical Engineering, NTU, Singapore.

 

Jan – Feb 2013: Visiting Associate Professor, School of Energy and Environment,  City University, Hong Kong.

 

March 2005 – Feb 2012: Assistant Professor, School of Chemical and Biomedical Engineering, NTU, Singapore.

 

Aug 2003 - Feb 2005: Postdoctoral Fellow, Institute of Bioengineering and Nanotechnology, A*STAR, Singapore.

 

March 2003 – July 2003: Travel research fellow in CNRS, Ecole Centrale de Lyon, France under the Australia-France Science and Technology Alliance Award

 

March 2000 – Feb 2003: PhD candidate and teaching assistant in the School of Chemical Engineering and Industrial Chemistry, the University of New South Wales, Australia.

 

 

Selected publications:

 

Citation Information

 

Total Citation: 2228

H-index: 26

 

Journal publication: 72

Book chapters: 4

Book editor: 1

Invited lecture: 13

 

Complete list of publication: http://www3.ntu.edu.sg/home/tytan/pubs/pubs.html

 

Selected publications in books

 

Editor

 

  • T T Y Tan (Editor), Rare Earth Nanotechnology, 2012 Pan Stanford Publishing, Print ISBN: 9789814316309.

http://www.panstanford.com/books/9789814316309.html

 

 

Selected publications in journals

*Corresponding authorship

 

 

  • Y Zhang, W Wei, GK Das, TTY Tan*, “Engineering Lanthanide-based Materials for Nanomedicine”, Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 2014, 20 p71-96. (An invited submission)
  • Wei Wei, Yan Zhang, Rui Chen, Julian Goggi, Na Ren, Ling Huang, Kishore K. Bhakoo, Handong Sun, Timothy Thatt Yang Tan* “Cross Relaxation Induced Pure Red Upconversion in Activator- and Sensitizer-Rich Lanthanide Nanoparticles” Chemistry of Materials 2014, 26, p5183.
  • Jing Liu, Ziming He, Jingwen Xue and Timothy Thatt Yang Tan*, “A metal-catalyst free flexible and free-standing chitosan/vacuum-stripped graphene/polypyrrole three dimensional electrode interface for high performance dopamine sensing’, J. Mater. Chem. B, 2014, 2 (17) p2478. (An invited submission to 2014 Emerging Investigators Theme Issue)
  • Aswan Al-Abboodi, Jing Fu, Pauline M. Doran, Timothy T.Y. Tan*, Peggy P.Y. Chan*, “Injectable 3D hydrogel scaffold with tailorable porosity post-implantationAdvanced Healthcare Materials, 2014, 3 (5) p725..
  • Ziming He, Hung Phan, Jing Liu, Thuc-Quyen Nguyen*, and Timothy Thatt Yang Tan*, “Understanding TiO2 Size-Dependent Electron Transport Properties of a Graphene-TiO2 Photoanode in Dye-sensitized Solar Cell Using Conducting Atomic Force Microscopy” Advanced Materials, 2013 25 47 p6900.
  • Peng Hu, Stevin Snellius Pramana, Shaowen Cao, Chee Keong Ngaw, Jingdong Lin, Say Chye Joachim Loo*, Timothy Thatt Yang Tan*, Ions Induced Synthesis of Uniform Single Crystalline Sulphide-based Quaternary Alloy Hexagonal Nanorings for Highly Efficient Photocatalytic Hydrogen Evolution, Advanced Materials, 2013 25 18 p2567.
  • Ziming He, Jing Liu, Yan Qiao, Chang Ming Li and Timothy Thatt Yang Tan*, Architecture engineering of hierarchically porous chitosan/vacuum-stripped graphene scaffold as bioanode for high performance microbial fuel cell,  Nano Letters 2012, 12 (9) p4738
  • Yang Liu, Timothy Thatt Yang Tan,* Shaojun Yuan and Cleo Choong*, Multifunctional P(PEGMA)-REDV conjugated titanium surfaces for improved endothelial cell selectivity and hemocompatibility, J. Mater. Chem. B, 2013, 1, 157
  • Yan Zhang, Jing Dong Lin, Vimalan Vijayaragavan, Kishore K. Bhakoo, and Timothy Thatt Yang Tan*, Tuning sub-10 nm single-phase NaMnF3 nanocrystals as ultrasensitive hosts for pure intense fluorescence and excellent T1 magnetic resonance imaging, Chem. Commun. 2012,48, 10322-10324
  • Qing Chi Xu, Yan Zhang, Ming Jie Tan, Yang Liu, Shaojun Yuan, Cleo Choong, Nguan Soon Tan, Timothy Thatt Yang Tan* “Anti-cAngptl4 Ab-conjugated N-TiO2/NaYF4:Yb,Tm Nanocomposite for Near Infrared-Triggered Drug Release and Enhanced Targeted Cancer Cell Ablation” Advanced Healthcare Materials, 2012 1 (4) p470.
  • Ziming He,  Guanhong Guai,  Jing Liu,  Chunxian Guo,  Joachim Say Chye Loo,  Chang Ming Li* and Timothy Thatt Yang Tan*, Nanostructure control of graphene-composited TiO2 by a one-step solvothermal approach for high performance dye-sensitized solar cells, Nanoscale, 2011, 3 (12), 4977.
  • Yong Wang, Feng Ai, Siu-Choon Ng*, Timothy Thatt Yang Tan*, Sub-2 µm Porous Silica Materials for Enhanced Separation Performance in Liquid Chromatography, An invited review article, Journal of Chromatography A, 2012, 1228, p99-109.
  • Qing Chi Xu, Yun Hau Ng, Yan Zhang, Joachim Say Chye Loo, Rose Amal,* and Timothy Thatt Yang Tan*, A Three-Way Synergy of Triple-Modified Bi2WO6/Ag/N-TiO2 Nanojunction Film for Enhanced Photogenerated Charges Utilization, Chem. Commun., 2011, 47 (30), 8641 – 8643
  • Gautom Kumar Das, Yan Zhang, Loyola D’Silva, Parasuraman Padmanabhan, Boon Chin Heng, Joachim Say Chye Loo, Subramanian Tamil Selvan, Kishore K. Bhakoo, and Timothy Thatt Yang Tan*, Single-Phase Dy2O3:Tb3+ Nanocrystals as Dual-Modal Contrast Agent for High Field Magnetic Resonance and Optical Imaging, Chemistry of Materials  2011, 23 (9), pp 2439–2446.
  • Yong Wang, Hui Chen, Yin Xiao, Cheong Hengq Ng, Ting Shan Oh, Timothy Thatt Yang Tan*, Siu Choon Ng*, Facile preparation of cyclodextrin chiral stationary phases via organic soluble catalytic “click” chemistry for enantioseparation of chiral drugs, Nature Protocols 2011 6 p935-942.
  • Qing Chi Xu, Diana V. Wellia, Yun Hau Ng, Rose Amal, Timothy Thatt Yang Tan*, Synthesis of Porous and Visible-light-active Bi2WO6/TiO2 Heterojunction Films with Improved Photoelectrochemical and Photocatalytic Performances, J. Phys. Chem. C, 2011 115 , 7419–7428.
  • Xinxin Zhao, Boon Chin Heng, Sijing Xiong, Jun Guo, Timothy Thatt-Yang Tan, Freddy Yin Chiang Boey, Kee Woei Ng, & Joachim Say Chye Loo, In Vitro Assessment of Cellular Responses to Rod-Shaped Hydroxyapatite Nanoparticles of Varying Lengths and Surface Areas, Nanotoxicology  2011  5(2): 182–194
  • Das, Gautom; Ng, Siu Choon; White, Timothy; Loo, Joachim; D'Silva, Loyola; Padmanabhan, P.; Bhakoo, Kishore; Selvan, S. Tamil; Tan, Timothy Thatt Yang* “Gadolinium Oxide Ultranarrow Nanorods as Multimodal Contrast Agents for Optical and Magnetic Resonance Imaging" Langmuir 2010, 26 (11), pp 8959–8965.
  • Lai-Sheng Li, Yong Wang, David James Young, Siu-Choon Ng, Timothy T.Y. Tan* "Monodispersed Submicron Porous Silica Particles Functionalized with CD Derivatives for Chiral CEC" Electrophoresis 2010, 31 378-387.  
  • Gautom Kumar Das, Peggy P.Y. Chan, Ailing Teo, Joachim Say Chye Loo, James Anderson, Timothy Thatt Yang Tan*in vitro Cytotoxicity Evaluation of Biomedical Nanoparticles and Their Extracts” Journal of Biomedical Materials Research A,  2010, 93A (1) 337-346.
  • Subramanian Tamil Selvan, Timothy Thatt Yang Tan, Dong Kee Yi and Nikhil R. Jana, Invited feature article “Functional and Multifunctional Nanoparticles for Bioimaging and Biosensing” Langmuir ,2010, 26 (14), pp 11631–11641.
  • Yunxia Zhang, Gautom Kumar Das, Rong Xu and Timothy Thatt Yang Tan*, “Tb-doped Iron Oxide: Bifunctional Fluorescent and Magnetic Nanocrystals” Journal of Materials Chemistry, 2009, 19, 3696–3703.
  • Charlene J W Ng, Han Gao, Timothy Thatt Yang Tan* “Atomic layer deposition of TiO 2 nanostructures for self-cleaning applications” Nanotechnology , 2008, 19, 445604.
  • Gautom Kumar Das and Timothy Thatt Yang Tan* “Rare-Earth Doped and Co-Doped Y 2O 3 Nanomaterials as Potential Bio-Imaging Probe” J. Phys. Chem. C, 2008, 112 (30), 11211–11217.
  • Timothy T. Tan , S. Tamil Selvan, Zhao Lan, Shujun Gao, Jackie Y. Ying “Size Control, Shape Evolution and Silica Coating of Near-Infrared-Emitting PbSe Quantum Dots” Chem Mat, 2007, 19(13), 3112.
  • Yunxia Zhang, Jun Guo, Tim White, Timothy Thatt Yang Tan*, Rong Xu* “Y 2O 3: Tb nanocrystals self-assembly into nanorods by oriented attachment mechanism” Journal of Physical Chemistry C, 2007, 111(22), 7893.
  • S. T. Selvan, T. T. Tan, J. Y. Ying, Robust, Non-Cytotoxic, Silica-Coated CdSe Quantum Dots with Efficient Photoluminescence ” Advanced Materials , 2005, 17, 1620.
  • T. T. Y. Tan, D. Beydoun and R. Amal, “Photocatalytic Reduction of Se(VI) in Aqueous Solutions in UV/TiO2 System: Kinetic Modeling and Reaction Mechanism,” Journal of Physical Chemistry B, 107 [18] (2003) pp4296-4303.

 

PhotoChemBioMed Lab @ SCBE, NTU