Professor PHAN Anh Tuan
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Articles
  1. Ngo K.H., Liew C.W, Heddi B., Phan A.T. (2024) Structural basis for parallel G-quadruplex recognition by an ankyrin protein. J. Am. Chem. Soc., 146, doi: 10.1021/jacs.4c01971.
  2. Paris J., Wilhelm C., Lebbé C., Elmallah M., Pamoukdjian F., Héraud A., Gapihan G., Walle A.V., Tran V.N., Hamdan D., Allayous C., Battistella M., Van Glabeke E., Lim K.W., Leboeuf C., Roger S., Falgarone G., Phan A.T., Bousquet G. (2024) PROM2 overexpression induces metastatic potential through epithelial-to-mesenchymal transition and ferroptosis resistance in human cancers. Clin. Transl. Med., 14, e1632.  
  3. Jelinska C., Kannan S., Frosi Y., Ramlan S.R., Winnerdy F., Lakshminarayanan R., Johannes C.W., Brown C.J., Phan A.T., Rhodes D., Verma C.S. (2023) Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein. RSC Chem. Biol., 4, 1096-1110.
  4. Mugunthan S., Wong L.L., Winnerdy F.R., Summers S., Bin Ismail M.H., Foo Y.H., Jaggi T.K., Meldrum O.W., Tiew P.Y, Chotirmall S.H., Rice S.A., Phan A.T., Kjelleberg S., Seviour T. (2023) RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms. Nat. Commun., 14, 7772.
  5. Jayasinghe M.K., Gao C., Yap G., Yeo B.Z.J., Vu L.T., Tay D.J.W., Loh W.X., Aw Z.Q., Chen H., Phung D.C., Hoang D.V., Prajogo R.C., Hooi L., Lim F.Q., Pirisinu M., Mok C.K., Lim K.W., Tang S.J., Tan K.S., Chow E.K., Chen L., Phan A.T., Chu J.J.H., Le M.T. (2023). Red blood cell-derived extracellular vesicles display endogenous antiviral effects and enhance the efficacy of antiviral oligonucleotide therapy. ACS Nano, 17, 21639–21661.
  6. Korsakova A., Phan A.T. (2023). Prediction of G4 formation in live cells with epigenetic data: a deep learning approach. NAR Genom. Bioinform., 5, lqad071. 
  7. Papp C., Jenjaroenpun P., Mukundan V.T., Phan A.T., Kuznetsov V.A. (2023) Dataset of bulged G-quadruplex forming sequences in the human genome. Data Brief, 50, 109550.
  8. Papp C., Mukundan V.T., Jenjaroenpun P, Winnerdy F.R., Ow G.S., Phan A.T., Kuznetsov V.A. (2023). Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization. Nucleic Acids Res., 51, 4148-4177.
  9. Das P., Phan A.T. (2022). Tetrad-binding ligands do not bind specifically to left-handed G-quadruplexes. Chem. Commun., 58, 11264-11267.
  10. Chen H., Jayasinghe M.K., Yeo E.Y.M., Wu Z., Pirisinu M., Usman W.M., Pham T.T., Lim K.W., Tran N.V., Leung A.Y.H., Du X., Zhang Q., Phan A.T., Le M.T.N. (2022). CD33-targeting extracellular vesicles deliver antisense oligonucleotides against FLT3-ITD and miR-125b for specific treatment of acute myeloid leukaemia. Cell Prolif., 55, e13255.
  11. Iyer V.S., Boddul S.V., Johnsson A.K., Raposo B., Sharma R.K., Shen Y., Kasza Z., Lim K.W., Chemin K., Nilsson G., Malmström V., Phan A.T., Wermeling F. (2022). Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2. J. Autoimmun., 131, 102857.
  12. Ngo K.H., Liew C.W., Lattmann S., Winnerdy F.R., Phan A.T. (2022). Crystal structures of an HIV-1 integrase aptamer: Formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex. Biochem. Biophys. Res. Commun., 613, 153-158.
  13. Bose K., Maity A., Ngo K.H., Vandana J.J., Shneider N.A., Phan A.T. (2022). Formation of RNA G-wires by G4C2 repeats associated with ALS and FTD. Biochem. Biophys. Res. Commun., 610, 113-118.
  14. Devi G., Winnerdy F.R., Ang J.C.Y., Lim K.W., Phan A.T. (2022). Four-layered intramolecular parallel G-quadruplex with non-nucleotide loops: An ultra-stable self-folded DNA nano-scaffold. ACS Nano, 16, 533-540.
  15. Patil K., Chin D., Seah H.L., Shi Q., Lim K.W., Phan A.T. (2021). G4-PROTAC: Targeted degradation of a G-quadruplex binding protein. Chem. Commun., 57, 12816-12819.
  16. Chatain J, Blond A, Phan A.T., Saintomé C, Alberti P. (2021). GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres. Nucleic Acids Res., 49, 7588-7601.
  17. Tan D.J.Y., Cheong V.V., Lim K.W., Phan A.T. (2021). A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides. Chem. Commun., 57, 5507-5510. (Inside Front Cover).
  18. Winnerdy F.R., Bakalar B., Das P., Heddi B., Marchand A., Rosu F., Gabelica V., Phan A.T. (2021). Unprecedented hour-long residence time of a cation in a left-handed G-quadruplex. Chem. Sci., 12, 7151-7157.
  19. Chan A., Korsakova A., Ong Y.S., Winnerdy F.R., Lim K.W., Phan A.T. (2021). RNA alternative splicing prediction with discrete compositional energy network. In ACM CHIL '21, New York, NY, USA, pp. 193-203. DOI: 10.1145/3450439.3451857.
  20. Dang D.T., Nguyen L.T.A., Truong T.T.T., Nguyen H.D., Phan A.T. (2021). Construction of a G-quadruplex-specific DNA endonuclease. Chem. Commun., 57, 4568-4571.
  21. Dao N.T., Haselsberger R., Khuc M.T., Phan A.T., Voityuk A.A., Michel-Beyerle M.E. (2021). Photophysics of DFHBI bound to RNA aptamer baby spinach. Sci. Rep., 11, 7356.
  22. Maity A., Winnerdy F.R., Chen G., Phan A.T. (2021). Duplexes formed by G4C2 repeats contain alternate slow- and fast-flipping G·G base pairs. Biochemistry, 60, 1097-1107.
  23. Seviour T., Winnerdy F.R., Wong L.L., Shi X., Mugunthan S., Foo Y.H., Castaing R., Adav S.S., Subramoni S., Kohli G.S., Shewan H.M., Stokes J.R., Rice S.A., Phan A.T., Kjelleberg S. (2021). The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures. NPJ Biofilms Microbiomes, 7, 27.
  24. Tran N.V, Nguyen L.T.A., Lim K.W., Phan A.T. (2021). Potent and selective knockdown of tyrosine kinase 2 by antisense oligonucleotides. ImmunoHorizons, 5, 70-80.
  25. Das P., Winnerdy F.R., Maity A., Mechulam Y., Phan A.T. (2021). A novel minimal motif for left-handed G-quadruplex formation. Chem. Commun., 57, 2527-2530.
  26. Das P., Ngo K.H., Winnerdy F.R., Maity A., Bakalar B., Mechulam Y., Schmitt E., Phan A.T. (2021). Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 1724-1736. (Review in Faculty Opinions).
  27. Tan D.J.Y., Winnerdy F.R., Lim K.W., Phan A.T. (2020). Coexistence of two quadruplex-duplex hybrids in the PIM1 gene. Nucleic Acids Res., 48, 11162-11171.
  28. Nguyen T.Q.N., Lim K.W., Phan A.T. (2020). Duplex formation in a G-quadruplex bulge. Nucleic Acids Res., 48, 10567-10575.
  29. Nguyen T.Q.N., Tooh Y.W., Sugiyama R., Nguyen T.P.D., Purushothaman M., Leow L.C., Hanif K., Yong R.H.S., Agatha I., Winnerdy F.R., Gugger M., Phan A.T., Morinaka B.I. (2020). Post-translational formation of strained cyclophanes in bacteria. Nat. Chem., 12, 1042-1053.
  30. Winnerdy F.R., Phan A.T. (2020). Quadruplex structure and diversity. Annu. Rep. Med. Chem., 54, 45-73.
  31. Nguyen T.Q.N., Lim K.W., Phan A.T. (2020). Folding kinetics of G-quadruplexes: Duplex stem loops drive and accelerate G-quadruplex folding. J. Phys. Chem. B, 124, 5122-5130.
  32. Tan D.J.Y., Das P., Winnerdy F.R., Lim K.W., Phan A.T. (2020). Guanine anchoring: A strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules. Chem. Commun., 56, 5897-5900.
  33. Yaneva M.Y., Cheong V.V., Cheng J.K., Lim K.W., Phan A.T. (2020). Stapling a G-quadruplex specific peptide. Biochem. Biophys. Res. Commun., 531, 62-66.
  34. Maity A., Winnerdy F.R., Chang W.D., Chen G., Phan A.T. (2020). Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs. Nucleic Acids Res., 48, 3315–3327. 
  35. Wang Z.F., Li M.H., Chu I.T., Winnerdy F.R., Phan A.T., Chang T.C. (2020). Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter. Nucleic Acids Res., 48, 1120-1130. 
  36. Ngo K.H., Yang R., Das P., Nguyen G.K.T., Lim K.W., Tam J.P., Wu B., Phan A.T. (2020). Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity. Chem. Commun., 56, 1082-1084.
  37. Heddi B., Cheong V.V., Schmitt E., Mechulam Y., Phan A.T. (2020). Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex. J. Struct. Biol., 209, 107399.
  38. Winnerdy F.R., Das P., Heddi B., Phan A.T. (2019). Solution structures of a G-quadruplex bound to linear- and cyclic-dinucleotides. J. Am. Chem. Soc., 141, 18038-18047.
  39. Pathak P., Yao W., Hook K.D., Vik R., Winnerdy F.R., Brown J.Q., Gibb B.C., Pursell Z., Phan A.T., Jayawickramarajah J. (2019). Bright G-quadruplex nanostructures functionalized with porphyrin lanterns. J. Am. Chem. Soc., 141, 12582-12591.
  40. Truong T.H.A., Winnerdy F.R., Phan A.T. (2019). An unprecedented knot-like G-quadruplex peripheral motif. Angew. Chem. Int. Ed., 58, 13834-13839.
  41. Winnerdy F.R., Bakalar B., Maity A., Vandana J.J., Mechulam Y., Schmitt E., Phan A.T. (2019). NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes. Nucleic Acids Res., 47, 8272-8281. (Cover article).
  42. Dang D.T., Phan A.T. (2019). Development of a ribonuclease containing a G4-specific binding motif for programmable RNA cleavage. Sci. Rep., 9, 7432.
  43. Ma Y., Iida K., Sasaki S., Hirokawa T., Heddi B., Phan A.T., Nagasawa, K. (2019). Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains. Molecules, 24, 263.
  44. Sengar A., Vandana J.J., Chambers V.S., Di Antonio M., Winnerdy F.R., Balasubramanian S., Phan A.T. (2019). Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter. Nucleic Acids Res., 47, 1564-1572.
  45. Bakalar B., Heddi B., Schmitt E., Mechulam Y., Phan A.T. (2019). A minimal sequence for left-handed G-quadruplex formation. Angew. Chem. Int. Ed., 58, 2331-2335.
  46. Nadai M., Doria F., Scalabrin M., Pirota V., Grande V., Bergamaschi G., Amendola V., Winnerdy F.R., Phan A.T., Richter S.N., Freccero M. (2018). A catalytic and selective scissoring molecular tool for quadruplex nucleic acids. J. Am. Chem. Soc., 140, 14528-14532.
  47. Butovskaya E., Heddi B., Bakalar B., Richter S.N., Phan A.T. (2018). Major G-quadruplex form of HIV-1 LTR reveals a (3 + 1) folding topology containing a stem-loop. J. Am. Chem. Soc., 140, 13654-13662.
  48. Sedghi Masoud S., Yamaoki Y., Ma Y., Marchand A., Winnerdy F.R., Gabelica V., Phan A.T., Katahira M., Nagasawa K. (2018). Analysis of interaction between telomeric i-motif DNA and a cyclic tetraoxazole compound. ChemBioChem, 19, 2268-2272.
  49. Bose K., Lech C.J., Heddi B., Phan A.T. (2018). High-resolution AFM structure of DNA G-wires in aqueous solution. Nat. Commun., 9, 1959.
  50. Asamitsu S., Obata S., Phan A.T., Hashiya K., Bando T., Sugiyama H. (2018). Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex. Chem. Eur. J., 24, 4428-4435.(Highlight as Spotlights Chemical Biology in Angew. Chem. Int. Ed., 2018 March 26, 57 (14), 3540.)
  51. Nguyen T.Q.N., Lim K.W., Phan A.T. (2017). A dual-specific targeting approach based on the simultaneous recognition of duplex and quadruplex motifs. Sci. Rep., 7, 11969. 
  52. Adrian M., Winnerdy F.R., Heddi B., Phan A.T. (2017). Rotation of guanine amino groups in G-quadruplexes: A probe for local structure and ligand binding. Biophys. J., 113, 775-784. (Highlight as New and Notable in Biophys. J., 2017 August 22, 113 (4), 757-758.)
  53. Piazza A., Cui X., Adrian M., Samazan F., Heddi B., Phan A.T., Nicolas A. (2017). Non-canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae. eLife, 6, e26884.
  54. Do N.Q., Chung W.J., Truong T.H.A., Heddi B., Phan A.T. (2017). G-quadruplex structure of an anti-proliferative DNA sequence. Nucleic Acids Res., 45, 7487-7493.
  55. Lech C.J., Phan A.T. (2017). Ball with hair: Modular functionalization of highly stable G-quadruplex DNA nano-scaffolds through N2-guanine modification. Nucleic Acids Res., 45, 6265-6274.
  56. De Nicola B., Lech C.J., Heddi B., Regmi S., Frasson I., Perrone R., Richter S.N., Phan A.T. (2016). Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome. Nucleic Acids Res., 44, 6442-6451.
  57. Heddi B., Martin-Pintado N., Serimbetov Z., Kari T.M.A., Phan A.T. (2016). G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding. Nucleic Acids Res., 44, 910-916.
  58. Cheong V.V., Lech C.J., Heddi B., Phan A.T. (2016). Inverting the G-tetrad polarity of a G-quadruplex by using xanthine and 8-oxoguanine. Angew. Chem. Int. Ed., 55, 160-163.
  59. Dang D.T., Phan A.T. (2016). Development of fluorescent protein probes specific for parallel DNA and RNA G-quadruplexes. ChemBioChem, 17, 42-45. (Back Cover article).
  60. Cheong V.V., Heddi B., Lech C.J., Phan A.T. (2015). Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G·G·X·O tetrad. Nucleic Acids Res., 43, 10506-10514. (Cover article).
  61. Heddi B., Cheong V.V., Martadinata H., Phan A.T. (2015). Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex. Proc. Natl. Acad. Sci. USA, 112, 9608-9613.
  62. Lim K.W., Jenjaroenpun P., Low Z.J., Khong Z.J., Ng Y.S., Kuznetsov V.A., Phan A.T. (2015). Duplex stem-loop-containing quadruplex motifs in the human genome: A combined genomic and structural study. Nucleic Acids Res., 43, 5630-5646. 
  63. Piazza A., Adrian M., Samazan F., Heddi B., Hamon F., Serero A., Lopes J., Teulade-Fichou M.P., Phan A.T., Nicolas A. (2015). Short loop-length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites. EMBO J., 34, 1718-1734.
  64. Chung W.J., Heddi B., Schmitt E., Lim K.W., Mechulam Y., Phan A.T. (2015). Structure of a left-handed DNA G-quadruplex. Proc. Natl. Acad. Sci. USA, 112, 2729-2733.
  65. Lech C.J., Phan A.T., Michel-Beyerle M.E., Voityuk A.A. (2015). Influence of base stacking geometry on the nature of excited states in G-quadruplexes: A time-dependent DFT study. J. Phys. Chem. B, 119, 3697-3705.
  66. Lim K.W., Nguyen T.Q.N., Phan A.T. (2014). Joining of multiple duplex stems at a single quadruplex loop. J. Am. Chem. Soc., 136, 17969-17973.
  67. Sengar A., Heddi B., Phan A.T. (2014). Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch. Biochemistry, 53, 7718-7723.
  68. You H., Zeng X., Xu Y., Lim C.J., Efremov A.K., Phan A.T., Yan J. (2014). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Res., 42, 8789-8795. 
  69. Adrian M., Ang D.J., Lech C.J., Heddi B., Nicolas A., Phan A.T. (2014). Structure and conformational dynamics of a stacked dimeric G-quadruplex formed by the human CEB1 minisatellite. J. Am. Chem. Soc., 136, 6297-6305.
  70. Li Z., Lech C.J., Phan A.T. (2014). Sugar-modified G-quadruplexes: Effects of LNA-, 2'F-RNA- and 2'F-ANA guanosine chemistries on G-quadruplex structure and stability. Nucleic Acids Res., 42, 4068-4079. 
  71. Martadinata H., Phan A.T. (2014). Formation of a stacked dimeric G-quadruplex containing bulges by the 5'-terminal region of human telomerase RNA (hTERC). Biochemistry, 53, 1595-1600.
  72. Lim K.W., Khong Z.J., Phan A.T. (2014). Thermal stability of DNA quadruplex-duplex hybrids. Biochemistry, 53, 247-257.
  73. Zhang L., Er J.C., Ghosh K.K., Chung W.J., Yoo J., Xu W., Zhao W., Phan A.T., Chang Y.T. (2014). Discovery of a structural-element specific G-quadruplex "light-up" probe. Sci. Rep., 4, 3776. 
  74. Chung W.J., Heddi B., Hamon F., Teulade-Fichou M.P., Phan A.T. (2014). Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3. Angew. Chem. Int. Ed., 53, 999-1002.
  75. Lim K.W., Ng V.C.M., Martin-Pintado N., Heddi B., Phan A.T. (2013). Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity. Nucleic Acids Res., 41, 10556-10562. 
  76. Chung W.J., Heddi B., Tera M., Iida K., Nagasawa K., Phan A.T. (2013). Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative. J. Am. Chem. Soc., 135, 13495-13501. (Review in Faculty of 1000).
  77. Lim K.W., Phan A.T. (2013). Structural basis of DNA quadruplex-duplex junction formation. Angew. Chem. Int. Ed., 52, 8566-8569. (Review in Faculty of 1000).
  78. Cao C., Zhang J., Wen X., Dobson S.L., Dao N.T., Wong L.M., Wang S., Li S., Phan A.T., Xiong Q. (2013). Metamaterials-based label-free nanosensor for conformation and affinity biosensing. ACS Nano, 7, 7583-7591. 
  79. Lech C.J., Phan A.T., Michel-Beyerle M.E., Voityuk A.A. (2013). Electron hole transfer in G-quadruplexes with different tetrad stacking geometries: A combined QM and MD study. J. Phys. Chem. B, 117, 9851-9856.
  80. Dao N.T., Haselsberger R., Michel-Beyerle M.E., Phan A.T. (2013). Excimer formation by stacking of G-quadruplex blocks. ChemPhysChem, 14, 2667-2671.
  81. Mukundan V.T, Phan A.T. (2013). Bulges in G-quadruplexes: Broadening the definition of G-quadruplex-forming sequences. J. Am. Chem. Soc., 135, 5017-5028. (Spotlight in Chem. Res. Toxicol., 2013 June 17, 26 (6), 839-840; Review in Faculty of 1000).
  82. Martadinata H., Phan A.T. (2013). Structure of human telomeric RNA (TERRA): Stacking of two G-quadruplex blocks in K+ solution. Biochemistry, 52, 2176-2183.
  83. Phan A.T., Do N.Q. (2013). Engineering of interlocked DNA G-quadruplexes as a robust scaffold. Nucleic Acids Res., 41, 2683-2688.
  84. Lech C.J., Heddi B, Phan A.T. (2013). Guanine base stacking in G-quadruplex nucleic acids. Nucleic Acids Res., 41, 2034-2046.
  85. Mukundan V.T, Tran Q.M.N., Miao Y.H., Phan A.T. (2013). Connecting magnetic micro-particles with DNA G-quadruplexes. Soft Matter, 9, 216-223.
  86. Lech C.J., Li Z., Heddi B, Phan A.T. (2012). 2'-F-ANA-guanosine and 2'-F-guanosine as powerful tools for structural manipulation of G-quadruplexes. Chem. Commun., 48, 11425-11427.
  87. Do N.Q., Phan A.T. (2012). Monomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study. Chem. Eur. J., 18, 14752-14759.
  88. Adrian M., Heddi B., Phan A.T. (2012). NMR spectroscopy of G-quadruplexes. Methods, 57, 11-24.
  89. Amrane S., Adrian M., Heddi B., Serero A., Nicolas A., Mergny J.L., Phan A.T. (2012). Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite. J. Am. Chem. Soc., 134, 5807-5816.
  90. Dao N.T., Haselsberger R., Michel-Beyerle M.E., Phan A.T. (2011). Following G-quadruplex formation by its intrinsic fluorescence. FEBS Lett., 585, 3969-3977.
  91. Lech C.J., Lim J.K.C., Lim J.M.W., Amrane S., Heddi B, Phan A.T. (2011). Effects of site-specific guanine C8-modifications on an intramolecular DNA G-quadruplex. Biophys. J., 101, 1987-1998.
  92. Swaminathan V., Liew H.F., Lew W.S., Hu L., Phan A.T. (2011). Photoelectrochemical studies of DNA-tagged biomolecules on Au and Au/Ni/Au multilayer nanowires. Nanoscale Res. Lett., 6, 535.
  93. Do N.Q., Lim K.W., Teo M.H., Heddi B., Phan A.T. (2011). Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity. Nucleic Acids Res., 39, 9448-9457. (Cover article).
  94. Mukundan V.T, Do N.Q., Phan A.T. (2011). HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges. Nucleic Acids Res., 39, 8984-8991.
  95. Martadinata H., Heddi B., Lim K.W., Phan A.T. (2011). Structure of long human telomeric RNA (TERRA): G-quadruplexes formed by four and eight UUAGGG repeats are stable building blocks. Biochemistry, 50, 6455-6461.
  96. Yue D.J.E., Lim K.W., Phan A.T. (2011). Formation of (3+1) G-quadruplexes with a long loop by human telomeric DNA spanning five or more repeats. J. Am. Chem. Soc., 133, 11462-11465. (Review in Faculty of 1000).
  97. Heddi B., Phan A.T. (2011). Structure of human telomeric DNA in crowded solution. J. Am. Chem. Soc., 133, 9824-9833. (Highlight in News of the Week of Chemical & Engineering News, 2011 June 13, 89 (24), 10; Highlight in JACS Select #20; Review in Faculty of 1000).
  98. Phan A.T., Kuryavyi V., Darnell J.C., Serganov A., Majumdar A., Ilin S., Raslin T., Polonskaia A., Chen C., Clain D., Darnell R.B., Patel D.J. (2011). Structure-function studies of FMRP-RGG peptide recognition of an RNA duplex-quadruplex junction. Nat. Struct. Mol. Biol., 18, 796-804.
  99. Lim K.W., Lacroix L., Yue D.J.E., Lim J.K.C., Lim J.M.W., Phan A.T. (2010). Coexistence of two distinct G-quadruplex conformations in the hTERT promoter. J. Am. Chem. Soc., 132, 12331-12342.
  100. Kuryavyi V., Phan A.T., Patel D.J. (2010). Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter. Nucleic Acids Res., 38, 6757-6773.
  101. Basundra R., Kumar A., Amrane S., Verma A., Phan A.T., Chowdhury S. (2010). A novel G-quadruplex motif modulates promoter activity of human thymidine kinase 1. FEBS J., 277, 4254-4264.
  102. Phan A.T. (2010). Human telomeric G-quadruplex: Structure of DNA and RNA sequences. FEBS J., 277, 1107-1117.
  103. Herbert B.S., Huppert J.L., Johnson F.B., Lane A.N., Phan A.T. (2009). Meeting report: Second international meeting on quadruplex DNA. Biochimie, 91, 1059-1065.
  104. Hu L., Lim K.W., Bouaziz S., Phan A.T. (2009). Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: Effect of loop length and sequence on the folding topology. J. Am. Chem. Soc., 131, 16824-16831. (Review in Faculty of 1000).
  105. Lim K.W., Alberti P., Guédin A., Lacroix L., Riou J.F., Roy N.J., Mergny J.L., Phan A.T. (2009). Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G•C•G•C tetrad. Nucleic Acids Res., 37, 6239-6248. (Cover article).
  106. Mendez-Bermudez A., Hills M., Pickett H.A., Phan A.T., Mergny J.L., Riou J.F., Roy N.J. (2009). Human telomeres that contain (CTAGGG)n repeats show replication instability in somatic cells and the male germline. Nucleic Acids Res., 37, 6225-6238. (Cover article).
  107. Martadinata H., Phan A.T. (2009). Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution. J. Am. Chem. Soc., 131, 2570-2578.
  108. Lim K.W., Amrane S., Bouaziz S., Xu W., Mu Y., Patel D.J., Luu K.N., Phan A.T. (2009). Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J. Am. Chem. Soc., 131, 4301-4309. (Review in Faculty of 1000).
  109. Amrane S., Ang R.W.L, Tan Z.M., Li C., Lim J.K.C., Lim J.M.W., Phan A.T. (2009). A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence. Nucleic Acids Res., 37, 931-938.
  110. Patel D.J., Phan A.T., Kuryavyi V. (2007). Human telomere, oncogenic promotor and 5’-UTR G-quadruplexes: Diverse higher-order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res., 35, 7429-7455.
  111. Phan A.T., Kuryavyi V., Luu K.N., Patel D.J. (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Res., 35, 6517-6525.
  112. Phan A.T., Kuryavyi V., Burge S., Neidle S., Patel D.J. (2007). Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J. Am. Chem. Soc., 129, 4386-4392. (Highlight in Cover Story of Chemical & Engineering News, 2007 May 28, 85 (22), 12-17; Review in Faculty of 1000).
  113. Phan A.T., Luu K.N., Patel D.J. (2006). Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Res., 34, 5715-5719.
  114. Phan A.T., Kuryavyi V., Patel D.J. (2006). DNA architecture: from G to Z. Curr. Opin. Struct. Biol., 16, 288-298.
  115. Phan A.T., Kuryavyi V., Luu K.N., Patel D.J. (2006). Structural diversity of G-quadruplex scaffolds. In Quadruplex Nucleic Acids (Balasubramanian, S. & Neidle, S., eds.), Royal Society of Chemistry U.K., pp. 81-99.
  116. Luu K.N., Phan A.T., Kuryavyi V., Lacroix L., Patel D.J. (2006). Structure of the human telomere in K+ solution: An intramolecular (3+1) G-quadruplex scaffold. J. Am. Chem. Soc., 128, 9963-9970. (Science & Technology article in Chemical & Engineering News, 2006 Jul, 84 (31), 46; Review in Faculty of 1000).
  117. Serganov A., Polonskaia A., Phan A.T., Breaker R.R., Patel D.J. (2006) Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature, 441, 1167-1171. (News & Views in Nature, 2006 Jun, 441, 1054-1055; Preview in Cell, 2006 Jul, 126, 19-22; Points of View in ACS Chemical Biology, 2006 Jul, 1, 341-345; Review in Faculty of 1000).
  118. Teplova M., Yuan Y.R., Phan A.T., Malinina L., Ilin S., Teplov A., Patel D.J. (2006). Structural basis for recognition and sequestration of UUUOH 3’ termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol. Cell, 21, 75-85. (Minireview in Mol. Cell, 2006 Jan, 21, 149-152; Research Focus in Trends Biochem. Sci., 2006 Jun, 31, 303-305).
  119. Zhang N., Phan A.T., Patel D.J. (2005). (3+1) assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex. J. Am. Chem. Soc., 127, 17277-17285.
  120. Phan A.T., Kuryavyi V., Gaw H.Y., Patel D.J. (2005). Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nat. Chem. Biol., 1, 167-173. (Research Highlights in Nature, 2005 Jul, 436, 445; in Nat. Struct. Mol. Biol., 2005 Aug, 12, 644; in Nat. Rev. Cancer, 2005 Sep, 5, 669).
  121. Phan A.T., Kuryavyi V., Ma J.B., Faure A., Andréola M.L., Patel D.J. (2005). An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase. Proc. Natl. Acad. Sci. USA, 102, 634-639. (From the cover; Research Focus in Trends Biochem. Sci., 2005 May, 30, 231-234).
  122. Serganov A., Keiper S., Malinina L., Tereschko V., Skripkin E., Höbartner C., Polonskaia A., Phan A.T., Wombacher R., Micura R., Dauter Z., Jäschke A., Patel D.J. (2005). Structural basis for Diels-Alder ribozyme catalyzed carbon-carbon bond formation. Nat. Struct. Mol. Biol., 12, 218-224. (Cover article; News & Views in Nat. Struct. Mol. Biol., 2005 Mar, 12, 206-208; Review in Faculty of 1000)
  123. Serganov A., Yuan Y.R., Pikovskaya O., Polonskaia A., Malinina L., Phan A.T., Hobartner C., Micura R., Breaker R.R., Patel D.J. (2004) Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem. Biol., 11, 1729-1741. (Cover article; News & Views in Chem. Biol., 2005 Jan, 12, 10-13; Review in Faculty of 1000).
  124. Phan A.T., Modi Y.S., Patel D.J. (2004). Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J. Am. Chem. Soc., 126, 8710-8716.
  125. Phan A.T., Modi Y.S., Patel D.J. (2004). Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) sequence interconverts between asymmetric dimeric G-quadruplexes in solution. J. Mol. Biol., 338, 93-102.
  126. Phan A.T., Patel D.J. (2003). Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: Distinct topologies, thermodynamic properties and folding/unfolding kinetics. J. Am. Chem. Soc., 125, 15021-15027.
  127. Phan A.T., Patel D.J. (2002). Differentiation between unlabeled and very-low-level fully 15N,13C-labeled nucleotides for resonance assignments in nucleic acids. J. Biomol. NMR, 23, 257-262.
  128. Phan A.T., Patel D.J. (2002). A site-specific low-enrichment 15N,13C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids. J. Am. Chem. Soc., 124, 1160-1161.
  129. Phan A.T., Mergny J.L. (2002). Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res., 30, 4618-4625.
  130. Phan A.T., Guéron M., Leroy J.L. (2001). Investigation of unusual DNA motifs. Methods Enzymol., 338, 341-371.
  131. Phan A.T. (2001). Through-bond correlation of sugar and base protons in unlabeled nucleic acids. J. Magn. Reson., 153, 223-226.
  132. Phan A.T. (2000). Long-range imino proton-13C J-couplings and the through-bond correlation of imino and non-exchangeable protons in unlabeled DNA. J. Biomol. NMR, 16, 175-178.
  133. Phan A.T., Leroy J.L. (2000). Intramolecular i-motif structures of telomeric DNA. J. Biomol. Struct. Dyn., Sp. Iss. S2, 245-252.
  134. Phan A.T., Guéron M., Leroy J.L. (2000). The solution structure and internal motions of a fragment of the cytidine-rich strand of the human telomere. J. Mol. Biol., 299, 123-144. (Cover article).
  135. Phan A.T., Leroy J.L., Guéron M. (1999). Determination of the residence time of water molecules hydrating B'-DNA and B-DNA, by the one-dimensional zero-enhancement nuclear Overhauser effect spectroscopy. J. Mol. Biol., 286, 505-519.
  136. Mergny J.L., Phan A.T., Lacroix L. (1998). Following G-quartet formation by UV-spectroscopy. FEBS Lett., 435, 74 -78.
  137. Leroy J.L., Nonin S., Han X., Phan A.T., Guéron M. (1998). Switching and looping in i-motif structures. In Structure, Motion, Interaction and Expression of Biological Macromolecules (Sarma, R.H. & Sarma, M.H., eds.), Adenine Press, Vol. 1, pp. 49-62.
  138. Nonin S., Phan A.T., Leroy J.L. (1997). Solution structure and base pair opening kinetics of the i-motif dimer of d(5mCCTTTACC): a noncanonical structure with possible roles in chromosome stability. Structure, 5, 1231-1246.

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