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Organometallic Chemistry
The
research interest is in the area of asymmetric synthesis and optical
resolution of novel P-chiral phosphine ligands. An efficient approach to
generate the desired stereoisomeric form of a particular ligand by means
of an unusual exo-endo stereochemically controlled asymmetric Diels-Alder
reaction, using a chiral organopalladium complex as the reaction promoter
have been developed. With this catalyst, it is now possible to
produce one particular target molecule in a controllable and
specific manner. Currently, these findings are applied to the synthesis
of new anti-cancer gold drugs. Thus far, preliminary biological
tests indicate that these new drugs exhibit high activity towards various
human cancerous diseases with minimal side effects. The catalytic
properties of these newly generated chiral phosphines are also being
investigated.
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