Professor LEUNG Pak Hing

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Organometallic Chemistry

The research interest is in the area of asymmetric synthesis and optical resolution of novel P-chiral phosphine ligands. An efficient approach to generate the desired stereoisomeric form of a particular ligand by means of an unusual exo-endo stereochemically controlled asymmetric Diels-Alder reaction, using a chiral organopalladium complex as the reaction promoter have been developed. With this catalyst, it is now possible to produce one particular target molecule in a controllable and specific manner. Currently, these findings are applied to the synthesis of new anti-cancer gold drugs. Thus far, preliminary biological tests indicate that these new drugs exhibit high activity towards various human cancerous diseases with minimal side effects. The catalytic properties of these newly generated chiral phosphines are also being investigated.


Last updated 28 July 2016 | Best viewed with Microsoft IE 6.0 and above