His projects mainly focuses on structural biology and protein-ligand interactions in particular, using X-ray crystallography.
Her project mainly focuses on protein structure, dynamics and interaction studies by NMR.
His project mainly focuses on protein characterization by NMR.
Computational Drug Design & Discovery / Structural Biology
De novo drug design, structure / ligand / fragment based pharamacophore & QSAR approaches targeting protein-protein interactions
Biochemical characterization of small molecules targeting infectious diseases such as Malaria, Tuberculosis
In-silico lead identification of Nurr1 agonists; MERS-DPP4
His project focuses on biochemical characterization of the novel lectin isolated from Singapore mistletoe and studying its application in medicine such as anti-cancer or antiviral agents.
His research involves structural and molecular characterization of human FKBP25 protein. He is also investigating the interaction of FKBP25 with DNA using NMR, X-ray crystallography and other biophysical methods.
Her project focuses on characterization of the HCV NS5A protein by NMR spectroscopy and biochemical approaches.
Her project focuses on understanding the molecular plasticity of anti-apoptotic Bcl-2 family proteins based on NMR spectroscopy and biochemical approaches, and its functional implication in apoptosis and regulation of calcium homeostasis.
Her project focuses on understanding the structural interaction between VRK1 and Macrohistone H2A1, and their interaction in the nucleosome core particle to provide insights for developing VRK1 inhibitors for cancer.
Her project focuses on the development of novel agonists for Nurr1 to enhance its transcriptional activity, a promising strategy to treat Parkinson’s Disease.
His project focuses on discovering small molecule therapeutics that target the binding interface of MERS-CoV RBD and hDPP4 and validating their potential antiviral properties using pseudotyped-viruses.