NTU School of Biological Sciences

Li Jinming

Assistant Professor
BS and MS, Beijing Normal University, PRC; Ph.D., Darmstadt University of Technology, Germany

Tel: (65) 6316 2866 
Fax: (65) 6791 3856 
Email: jmli@ntu.edu.sg

 

 

Professional experience

 

ˇ  Lecturer, School of Bioscience, China Agricultural University, PRC

ˇ  Ph.D. candidate, Dept Math Darmstadt Tech. Univ., Germany

ˇ  Postdoctorate associate, Yale University School of Medicine, USA

ˇ  Associate research scientist, Yale University School of Medicine, USA

ˇ  Assistant Professor, SBS, NTU, SG

 

Research interests

 

ˇ  Bioinformatics
Recent advances in large-scale DNA expression measurements and proteomics technologies have opened the opportunity for massively parallel biological data acquisition and thus have shifted our attention towards an integrated understanding of the genetic networks underlying complex biological phenotypes. My research interest in this area focus on developing statistical methods to identify differentially expressed genes for both cDNA microarray experiments and high density oligo-nucleotide microarray experiments;developing model-based and other novel approaches related to microarray data analysis; developing computational and visualization tools to analyze biological pathways and gene regulating networks and developing novel tools and algorithms for DNA and protein sequence analysis.

 

ˇ  Statistical Genetics
linkage and association studies represent two types of research designs that geneticists commonly use to locate disease genes. We will focus on developing statistical methods and computer programs for both linkage and association study designs. Another interesting field is to develop the statistical and computing tools to analyze human chromosome nondisjunction, such as trisomy and uniparental disomy, which results in several common genetic diseases.

 

ˇ  Mathematical Modeling in the Biology
Focus on evolutionary game dynamics.

 

Teaching

  • BS105 Basic Computing --- subject coordinator / lecturer
  • BS205 Biostatistics --- lecturer
  • BS210 Bioinformatics --- subject coordinator / lecturer
  • BS304 Genomics and Advanced Genetics --- lecturer

 

Selected Publication List

 

[1].         Ou Li, Jinming Li, Peter Dröge, DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells.  FEBS Letters,  581(18),3533-3537, 2007

[2].         Le Lu, Hui Jia, Peter Dröge and Jinming Li, The Human Genome-wide Distribution of DNA Palindromes, Functional & Integrative Genomics, 7(3), 221-227, 2007

[3].         Hui Jia, Le Lu, Shiau-Chuen Hng and Jinming Li, Simulation Study of Ratio Calculation Formulas of two-color cDNA Microarray Data, Applied Bioinformatics, 5(4), 255-266, 2006

[4].         Leo JC, Wang SM, Guo CH, Aw SE, Zhao Y, Li JM, Hui KM, Lin VC., Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptor.  Int J Cancer., 117(4):561-568 2005

[5].         Samuel Shao-Min Zhang, Xuming Xu, Jinming Li, Mu-Gen Liu, Hongyu Zhao, M. Bento Soares, Colin J Barnstable  and Xin-Yuan Fu, Comprehensive in silico functional specification of mouse retina transcripts. BMC Genomics,  6:40, 2005

[6].         Ying Gao, Jinming Li, Elizabeth Strickland, Sujun Hua, Hongyu Zhao, Zhangliang Chen, Lijia Qu, Xing Wang Deng, An Arabidopsis Promoter Microarray and its Initial Usage in the Identification of HY5 Binding Targets in vitro. Plant Molecular Biology, Vol 54, No 5: 683-699, 2004.

[7].         Corona, T., Bao, Q., Christ, N., Schwartz, T., Jinming Li and Droge, P. Activation of site-specific integration in human cells by a single chain integration host factor. Nucleic Acid Research, Vol 31, No 17, 2003

[8].         Kei-Hoi Cheung, Kevin White, Janet Hager, Mark Gerstein, Valerie Reinke, Kenneth Nelson, Peter Masiar, Ranjana Srivastava, Yuli Li, Ju Li, Jinming Li, David B. Allison, Michael Snyder, Perry Miller, Kenneth Williams. YMD: A microarray database for large-scale gene expression analysis. Proc AMIA Symp. 2002: 140-4

[9].         Shuanglin Zhang, Kui Zhang, Jinming Li, and Hongyu Zhao, On a family-based haplotype pattern mining method for linkage disequilirbium mapping. Pac Symp Biocomputing 7:100-111, 2002.

[10].     Ligeng Ma, Ying Gao, Lijia Qu, Zhangliang Chen, Jinming Li, Hongyu Zhao, and Xingwang Deng, Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis, Plant Cell, 14: 2383-2398, 2002.

[11].     Haiyang Wang, Ligeng Ma, Jassica Haboshi, Jinming Li, Hongyu Zhao , Xing Wang Deng, Analysis of far-red light regulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis, Plant J., 22, 723-733, 2002,.

[12].     Jinming Li, Stephanie Sherman, Neil Lamb, Hongyu Zhao; Genetic Mapping with Trisomy Data, American Journal of Human Genetics, 69:1255-1265, 2001.

[13].     Haiyang Wang, Ligeng Ma, Jinming Li, Hongyu Zhao, Xingwang Deng, Direct Interaction of Arabidopsis Cryptochromes with COP1 in Light Control Development, Science, 294: 154-158, 2001.

[14].     Ligeng Ma, Jinming Li, Lijia Qu, Janet Hager, Zhangliang Chen, Hongyu Zhao, Xinwang Deng; Light control of Arabidopsis development entails co-ordinated regulation of genome expression and cellular pathways, Plant Cell, Vol 13, No.12, 2001.

[15].     Hongyu Zhao, Jinming Li, and Wendy P. Robinson; Statistical Analysis of Uniparental Disomy Data Using Hidden Markov Models. Biometrics, Vol. 57, No.4, 2001.

[16].     Jinming Li, Dai Wang, Jianping Dong, Renfang Jiang, Kui Zhang, Shuanglin Zhang, Hongyu Zhao and Fenzhu Sun; The Power of Transmission Disequilibrium Tests for Quantitative Traits. Genetic Epidemiology, 21: S632-637, 2001

[17].     Shuanglin Zhang, Kui Zhang, Jinming Li, Fengzhu Sun and Hongyu Zhao; Test of linkage and association for quantitative traits in general pedigrees: the quantitative pedigree disequilibrium test. Genetic Epidemiology, 21: S370-375, 2001

[18].     Hongyu Zhao, Jinming Li, and Wendy P. Robinson; Multipoint genetic mapping with uniparental disomy data. American Journal of Human Genetics, 67:851-861, 2000.

[19].     Jinming Li, Das dynamische Verhalten diskreter Evolutionsspiele. Shaker Verlag, Aachen, 1999. (in German)

[20].     Jinming Li and Laifu Liu An exponential ESS model and its application to frequency-dependent selection. Mathematical Bioscience, Vol.96, No. 2, 185-194, 1989.

[21].     Jinming Li ESS Theory and the Evolution of Animal Conflict Behavior, Natural Journal (in chinese), Vol.11, No.5, 325-334, 1988.

 

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