Niche Applications of Functional Cyclodextrins

III-2: Niche Applications of Functional Cyclodextrins

S. C. Ng
Division of Chemical & Biomolecular Engineering, College of Engineering
Chiral Sciences and Technology Pte. Ltd. (http://www.chiralpure.com)

Abstract
The PI has been working on the following aspects/ technology:
  1. Chiral Stationary Phases (CSP) for analytical and process scale enantioseparations.
  2. Chiral Ionic Liquids: Novel applications in Enantioseparations.
  3. Chiral Quartz Crystal Microbalance (QCM): An approach towards a rapid methodology for correlating structures of the chiral selector to Enantioseparations of specific analytes.
Key IPs / publications created have resulted in a technology spin-off company1, 2. In this presentation, key thoughts on the applications of functional cyclodextrins in the following areas will be presented.
  1. Applications of cyclodextrins (CD) / CD-based ionic liquids for stabilization and size control of gold nanoparticles.
  2. Nanocomposites for applications in chiral separation technologies.
References
  1. Representative patents: S C Ng et. al., (a) US 6,017,458 (2000); (b) PCT WO 01/98370 (2001); (c) US 6,296,768 (2001); (d) US 6,720,285 (2004); (e) SGP 69210 (2000); (f) US Patent, Appl. No. 10/054,162 (2002); (g) US Patent, Appl. No. 60/529,112 (2003).
  2. Representative relevant papers: (a) Lai, X. H. and S C Ng, Tetrahedron Lett., 45 (2004):4469- 4472; (b) Lai, X. H. and S C Ng, J. Chromatogr. A, 1031 (2004): (c) 135-142; Ng, S C, T Sun and H S O Chan, Macromolecular Sym., 92 (2003): 171-181; (d) Bai, Z W, C B Ching and S C Ng, Chromatographia, 58 (2003): 43-46; (e) Lai, X. H. and S C Ng, Tetrahedron Lett., 44 (2003): 2657-2660; (f) Ng, S C, T Sun and H S O Chan, Tetrahedron Lett., 43 (2002): 2863-2866; (g) Ng, S C, T T Ong, P Fu and C B Ching, J. Chromatogr. A, 968 (2002): 31-40; (h) Ng, S C, L Chen and C B Ching, Tetrahedron Lett., 43 (2002): 667-681; (i) Li, D-B, S C Ng and I Novak, Tetrahedron Lett., 43 (2002): 1871-187; (j) Ching, C B, P Fu, S C Ng and Y K Xu, J. Chromatogr. A, 898 (2000): 53-61; (k) Zhang, L F, S C Ng, L Chen and C B Ching, Tetrahedron Letters, 40 (1999): 1815-1818; (l) Ng, S C, W L Yu and A C H Huan, Advanced Materials, 9 (1997): 887. Ng, S C, P Miao and H S O Chan Advanced Materials, 10 (1998): 782-786.