CURRICULUM VITAE

Assistant Professor Liu Xuewei
School of Physical & Mathematical Sciences
Nanyang Technological University
1 Nanyang Walk, Block 5, Level 3-60
Singapore 637616

E-mail: xuewei@ntu.edu.sg
Tel: (+65) 6316 8901
Fax: (+65) 6316 6984


Educational Qualifications and Academic History 

1993
1996
2000
2000-2002
2002-2003
2003-2005

 B.Sc., Chemistry, China Agricultural University
M.Sc., Chemistry, China Agricultural University
PhD, Chemistry,  University of Southern California
Research Scientist, Proctor &Gamble Pharmaceuticals
Senior Research Scientist, Chugai Pharma USA
Postdoctoral Research Fellow, Division of Chemistry and Chemical Engineering, California Institute of Technology
 

Research interests

      The Research program in our group will integrate organic chemistry, chemical biology, medicinal chemistry and drug delivery. A special emphasis is placed on training and  research in organic synthesis and on the utilization of this expertise in addressing problems of medicinal and biochemical significance.  

      1.  New synthetic methodology and synthesis 

      2. Chemical tools for biological interest: Aging-associated Alzheimer’s disease is a fatal, progressive dementia for which there is no cure and for which a molecular basis has yet to be established.  

Awards & Fellowships

Publications

    1.   Xuewei Liu, Doreen Cross Doersen, Anny-Odile Colson and Frank H. Ebetino, “Synthesis and Biological Activity of Novel Peptidomimetics as Melanocortin Receptor Agonists”, Peptides, submitted, 2005.
    2.   Xuewei Liu, Jeifei Chen, Thomas Arrehinius; “Heterocyclic Compounds as Malonyl-CoA Decarboxylase Inhibitors” U.S. Pat. Appl. Publ. (2005), 18 pp. US  2005026969  A1  20050203 CAN 142:198073  AN 2005:99174.
    3. Ron S. Ronimus, Xuewei Liu, Russell S. Roberson, Charles E. McKenna, and Hugh W. Morgan, “Inhibition of the Active Pyrophosphate-dependent Phosphofructokinases from the Syphilis Pathogen Treponema Pallidum and Lyme Disease Spirochete Borrelia Burgdorferi Using Bisphosphonates”, Biochem. Pharmacol., Accepted, 2005.
    4. Xuewei Liu, Robert Shoemaker and Charles E. McKenna, “Synthesis human Herpesvirus 8 Inhibitory Properties of Some Phosphonoformate, Phosphonoacetate and Methylenebisphosphonate Pyrophosphate Analogues”, J. Med. Chem., Accepted, 2005.
    5. Sarah T. Tully, Ross Mabon, Cristal Gama, Sherry M. Tsai, Xuewei Liu and Linda C. Hsieh-Wilson “A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth", J. Am. Chem. Soc. 2004, 126, 7736.
    6. Frank H. Ebetino, Xuewei Liu, Mark G. Solinsky, John A. Wos; “Melanocortin receptor ligands”. PCT Int. Appl. (2003), 98 pp. WO 2003093234 A1 20031113 AN 2003: 892748.
    7. Frank H. Ebetino, Xuewei Liu, Mark G. Solinsky, John A. Wos, Rashid N. Mumin; “N-Acyl piperidine derivatives for use as melanocortin receptor ligands in the treatment of feeding disorders”. PCT Int. Appl. (2003), 64 pp. CODEN: PIXXD2 WO 2003092690 A1 20031113 AN 2003: 892615.
    8. Xuewei Liu, X. Eric Hu, Xinrong Tian, Adam Mazur, and Frank H. Ebetino, “Enantioselective Synthesis of Phosphinic Peptidomimetics via Asymmetric Michael Addtion of Phosphinic Acids and Acrylate Derivatives”, J. Organometallic Chem., 646, 2002, 212-222.
    9. Andrew S. Kende, Hanqing Dong, Xuewei Liu, and Frank H. Ebetino, “A useful synthesis of the Phe-Arg phosphinic acid dipeptide isostere”, Tetrahedron Lett. 43, 2002, 4973.
    10. Frank H. Ebetino, David L. Soper, Michelle J. Dirr, Mark W. Lundy, Glen Mieling, John A. Wos, Mitchell A. deLong, and Xuewei Liu, “The Rational Design and Utility of Drugs with Phos-phonic/phinic Acids, From Enzyme Inhibitors to Bioisosteric Receptor Agonists”, Phosphorus, Sulfur, Silicon and Relat. Elem., 2002, 177, 1725.
    11. Frank H. Ebetino, Xuewei Liu, et al., “Modeling of Bisphosphonate Binding to Farnesyl Diphosphate Synthase”, Bone, 2002, 30, 16S.
    12. Charles E. Mckenna, Zengmin Li, Xuewei Liu; “Preparation and Antiviral Activity of Pyrophosphate Analogs”, US 6444837 (2002).
    13. Charles E. Mckenna, Xuewei Liu; “Preparation and Use of Sulfur-Containing Phosphonoformate Derivatives and Analogues”, US 6441214 (2000).
    14. Xuewei Liu, Zengmin Li and Charles E. McKenna, “Synthetic and Theoretical Investigations of Some Sulfur-Containing Phosphonoformate Derivatives”, Phosphorus, Sulfur, Silicon and Relat. Elem., 1999, 147, 1041.