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Introduction
Works in our
laboratory are focused on developing new and elegant asymmetric catalytic
systems that are highly efficient and practical and of broad utility to
synthetic organic chemistry. We are interested in the application of
these novel methodologies to the construction of bioactive natural
products and as practical synthetic tools for drug discovery, Medicinal
Chemistry and Materials Science. Current research
themes studied in our group are focused on the development of new stereoselective functional group transformations
based on C-H bond functionalization and Lewis and Brønsted
acid catalysis.
Selected Recent Publications
1. “Ytterbium(III) Triflate-Catalyzed Tandem Friedel-Crafts Alkylation/Hydroarylation
of Propargylic Alcohols with Phenols as an Expendient Route to Indenols”, Zhang,
X.; Teo, W. T.; Chan, P. W. H. Org. Lett. 2009, 11, 4990.
2. “Highly
Efficient Synthesis of Tri- and Tetrasubstituted
Conjugated Enynes from Brønsted
Acid-Catalyzed Alkoxylation of
1-Cyclopropylprop-2-yn-1-ols with Alcohols”, Mothe,
S. R.; Chan, P. W. H. J. Org. Chem. 2009, 74, 5887.
3. “Ytterbium(III)
Triflate-Catalyzed Amination
of 1-Cyclopropylprop-2-yn-1-ols as an Expedient Route to Conjugated Enynes”, Rao,
W.; Zhang, X.; Sze, E. M. L.; Chan, P. W. H. J. Org.
Chem. 2009,
74, 1740.
4. “Gold- and
Silver-Catalyzed Tandem Amination/Ring
Expansion of Cyclopropylmethanols with Sulfonamides as an Expedient Route
to Pyrrolidines”, Rao,
W.; Chan, P. W. H. Chem. Eur. J. 2008, 14,
10486.
5. “Highly
Efficient Ruthenium(II) Porphyrin-Catalyzed
Amidation of Aldehydes”,
Chang, J. W. W.; Chan, P. W. H. Angew. Chem., Int. Ed. 2008, 47, 1138.
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