Publications

Home l Group l Research focus l Publications l News article about the group l Positions available

REPRESENTATIVE PUBLICATIONS:

(two in Nature, seven in Angew Chem, five in JACS and one in PNAS)

1.	Chua, Sock Teng; Quek, Ngee Mien; Li, Ming; Ng, Magdeline Tao Tao; Yuan, Weixing; Chua, May Ling; Guo, Juanjuan; Koh, Li Eng; Ye, Ruijuan; Li, Tianhu. Nick-containing oligonucleotides as human topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters (2009), 19(3), 618-623.
2.	“Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats”, Xinming Li , Magdeline Tao Tao Ng , Yifan Wang, Tianyan Zhou, Sock Teng Chua, Weixing Yuan, Tianhu Li, Bioorg. Med. Chem. Lett. 2008
3.	Yifan Wang, Magdeline Tao Tao Ng, Tianyan Zhou, Xinming Li, Choon Hong Tan, Tianhu Li. C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic & Medicinal Chemistry Letters 18 (2008), 3597–3602
4.	Xiaoqian Liu, Xinming Li, Tianyan Zhou, Yifan Wang, Magdeline Tao Tao Ng, Wei Xu and Tianhu Li* Site specific self-cleavage of certain assemblies of G-quadruplex, Chem. Commun. 2008, 380 – 382
5.	Yifan Wang, Xinming Li, Xiaoqian Liu and Tianhu Li, An i-motif-containing DNA device that breaks certain forms of Watson–Crick interactions, Chem. Commun., 2007, 4369–4371.
6.	Li, Xinming; Ng, Magdeline Tao Tao; Wang, Yifan; Liu, Xiaoqian; Li, Tianhu. Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic & Medicinal Chemistry Letters (2007), 17(17), 4967-4971.
7.	Tianyan Zhou^, Yifan Wang, Xinming Li, Qiang Zhangand Tianhu Li^,Synthesis and Characterization of a Fluorescein-Labeled Circular G-Quadruplex, Bulletin of the Chemical Society of Japan, Vol. 79, No. 8 pp.1300-1302, (2006)
8.	Tianyan Zhou, Guoshu Chen, Yifan Wang, Qiang Zhang, Ming Yang and Tianhu Li, Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes, Nucleic Acids Research, 32, No. 21 e173 (2004)
9.	Dongsheng Liu, Jian Chen, Alex H. F. Lee, Larry M. C. Chow, Albert S. C. Chan, and Tianhu Li. Small Circular Oligodeoxynucleotides Achieved from Self-Assembling Entities. Angew. Chem., Int. Ed. Engl. (2003), 42 (7), 797-799.
10.	Qi, Jianying; Li, Tianhu; Chan, Albert S. C. Fungicide chinomethionate as a new family of photoinducible DNA-cleaving agents. Bioorganic & Medicinal Chemistry Letters (2003), 13(20), 3561-3563.
11.	Lee, Alex H. F.; Chan, Albert S. C.; Li, Tianhu. Synthesis of 5-(7-hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin. Phosphorus, Sulfur, and Silicon and the Related Elements (2003), 1163-1174.
12.	Tianyan Zhou, Qiang Zhang, Ming Yang, and Tianhu Li, Fabrication of unimolecularly circular G-quadruplexes as prospective molecular probes, manuscript submitted to Nucleic Acids Research on July 7, 2003 and revision of the original draft according to reviewers’ suggestions is in progress.
13.	Lee, A. H. F.; Chen, J.; Liu, D.; Leung, T. Y. C.; Chan, Albert S. C.; Li, Tianhu. Acid-Promoted DNA-Cleaving Activities and Total Synthesis of Varacin C. Journal of the American Chemical Society (2002), 124(47), 13972-13973.
14.	Lee, Alex H. F.; Chan, Albert S. C.; Li, Tianhu. Acid-accelerated DNA-cleaving activities of antitumor antibiotic varacin. Chemical Communications (Cambridge, United Kingdom) (2002), (18), 2112-2113.
15.	Chen, Jian; Liu, Dongsheng; Lee, Alex H. F.; Qi, Jianying; Chan, Albert S. C.; Li, Tianhu. G-quadruplex as a new class of structural entities for directing the formation of circular oligodeoxyribonucleotides. Chemical Communications (Cambridge, United Kingdom) (2002), (22), 2686-2687.
16.	Lee, Alex H. F.; Chan, Albert S. C.; Li, Tianhu. Benzotrithiole 2-oxide: A new family of thiol-Activated DNA-Cleaving functionalities. Bioorganic & Medicinal Chemistry Letters (2002), 12(22), 3259-3261.
17.	Lee, Alex H. F.; Zhou, Zhongyuan; Li, Tianhu; Chan, Albert S. C. Varacinium chloride. Acta Crystallographica, Section E: Structure Reports Online (2002), E58(4), o465-o466.
18.	Li, Tianhu; Liu, D.; Chen, J.; Lee, A. H. F.; Chan, A. S. C. Construction of Circular Oligodeoxyribonucleotides on the New Structural Basis of i-Motif. Journal of the American Chemical Society (2001), 123(51), 12901-12902.
19.	Nicolaou, K. C.; Pfefferkorn, Jeffrey; Xu, Jinyou; Winssinger, Nicolas; Ohshima, Takashi; Kim, Sanghee; Hosokawa, Seijiro; Vourloumis, Dionisios; Van Delft, Floris; Li, Tianhu. Total synthesis and chemical biology of the sarcodictyins. Chemical & Pharmaceutical Bulletin (1999), 47(9), 1199-1213.
20.	Couladouros, Elias A.; Li, Tianhu; Moutsos, Vassilios I.; Pitsinos, Emmanuel N.; Soufli, Ioanna C. Stabilization of microtubules by combretastatin D derivatives. Bioorg. Med. Chem. Lett. (1999), 9(20), 2927-2928.
21.	Nicolaou, K. C.; Winssinger, N.; Vourloumis, D.; Ohshima, T.; Kim, S.; Pfefferkorn, J.; Xu, J.-Y.; Li, T. Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries. J. Am. Chem. Soc. (1998), 120(42), 10814-10826.
22.	Nicolaou, K. C.; He, Y; Roschangar, F; King, N. P.; Vourloumis, Dionisios; Li, Tianhu. Total synthesis of epothilone E & analogs with modified side chains through the Stille coupling reaction. Angew. Chem., Int. Ed. (1998), 37(1/2), 84-87.
23.	Nicolaou, K. C.; Kim, S; Pfefferkron, J; Xu, J.; Ohshima, Takashi; Hosokawa, Seijiro; Vourloumis, Dionisios; Li, Tianhu. Synthesis and biological activity of sarcodictyins. Angew. Chem., Int. Ed. (1998), 37(10), 1418-1421.
24.	Nicolaou, K. C.; Finlay, M. Ray V.; Ninkovic, Sacha; King, N. Paul; He, Yun; Li, Tianhu; Sarabia, Francisco; Vourloumis, Dionisios. Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones. Chem. Biol. (1998), 5(7), 365-372.
25.	Plyta, Zoi F.; Li, Tianhu; Papageorgiou, Vassilios P.; Mellidis, Antonios S.; Assimopoulou, Andreana N.; Pitsinos, Emmanuel N.; Couladouros, Elias A. Inhibition of topoisomerase i by naphthoquinone derivatives. Bioorganic & Medicinal Chemistry Letters (1998), 8(23), 3385-3390.
26.	Li, Tianhu; Nadin, Alan. "Correlation between time reversal symmetry and chirality in certain molecular processes". Chirality (1998), 10(4), 289-293.
27.	Nicolaou, K. C.; Winssinger, N.; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E. Synthesis of epothilones A and B in solid and solution phase. Nature (London) (1997), 387(6630), 268-272.
28.	Nicolaou, K. C.; Vourloumis, Dionisios; Li, Tianhu; Pastor, Joaquin; Winssinger, Nicolas; He, Yun; Ninkovic, Sacha; Sarabia, Francisco; Vallberg, Hans; Roschangar, Frank; King, N. Paul; Finlay, M. Ray V.; Giannakakou, Pareskevi; Verdier-Pinard, Pascal; Hamel, Ernest. Designed epothilones: combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells. Angew. Chem., Int. Ed. Engl. (1997), 36(19), 2097-2103.
29.	Nicolaou, K. C.; Ninkovic, Sacha; Finlay, M. Ray V.; Sarabia, Francisco; Li, Tianhu. Total synthesis of 26-hydroxyepothilone B and related analogs. Chem. Commun. (Cambridge) (1997), Issue 24, 2343-2344.
30.	Nicolaou, K. C.; van Delft, Floris; Ohshima, Takashi; Vourloumis, Dionisios; Xu, Jinyou; Hosokawa, Seijiro; Pfefferkorn, Jeffrey; Kim, Sanghee; Li, Tianhu. Total synthesis of eleutherobin. Angew. Chem., Int. Ed. Engl. (1997), 36(22), 2520-2524.
31.	Li T; Weinstein D S; Nicolaou K The chemical end-ligation of homopyrimidine oligodeoxyribonucleotides within a DNA triple helix. Chemistry and Biology (1997 Mar), 4(3), 209-14.
32.	Lazo J S; Li T; Woo E S; Settineri C E; Allan W P; Yalowich J C Chemical synthesis and biological activity of a novel fluorescent etoposide derivative. Biochemical Pharmacology (1997 Mar 7), 53(5), 715-22.
33.	Liu, Chen; Smith, Brian M.; Ajito, Keiichi; Komatsu, Hironori; Gomez-Paloma, Luigi; Li, Tianhu; Theodorakis, Emmanuel A.; Nicolaou, K. C.; Vogt, Peter K. Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function. Proc. Natl. Acad. Sci. U. S. A. (1996), 93(2), 940-4.
34.	Nicolaou, K. C.; Ajito, Keiichi; Komatsu, Hironori; Smith, Brian M.; Li, Tianhu; Egan, Miles G.; Gomez-Paloma, Luigi. DNA-carbohydrate recognition: design and synthesis of an eight-base sequence-selective DNA-binding oligosaccharide. Angew. Chem., Int. Ed. Engl. (1995), 34(5), 576-8.
35.	Li, Tianhu; Nadin, Alan. "Theoretical aspects of time reversal symmetry violation in ring current molecules" Physics Letters A (1995), 206(3,4), 222-4.
36.	Li, T.; Nicolaou, K. C. Chemical self-replication of palindromic duplex DNA. Nature (London) (1994), 369(6477), 218-21.
37.	Li, Tianhu; Zeng, Qinping; Rokita, Steven E.. Target-Promoted Alkylation of DNA. Bioconjugate Chemistry (1994), 5(6), 497-500.
38.	Li, Tianhu; Zeng, Zijian; Estevez, Virginia A.; Baldenius, Kai U.; Nicolaou, K. C.; Joyce, Gerald F. Carbohydrate-Minor Groove Interactions in the Binding of Calicheamicin g1I to Duplex DNA. J. Am. Chem. Soc. (1994), 116(9), 3709-15.
39.	Nicolaou, K. C.; Li, T.; Nakada, M.; Hummel, C. W.; Hiatt, A.; Wrasidlo, W. Calicheamicin : through molecular design to a compound that cleaves DNA selectively and efficiently and initiates cell death. Angew. Chem. (1994), 106(2), 195-8 (See also Angew. Chem., Int. Ed. Engl., 1994, 33(2), 183-6).
40.	Li, Tianhu, A possible role of molecular decay in the origin of asymmetric emergence of biomolecules on earth. Journal of Theoretical Biology (1994), 170(2), 227-30.