Assistant Professor PHAN Anh Tuan
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Research Articles
  1. Nonin S., Phan A.T., Leroy J.L. (1997). Solution structure and base pair opening kinetics of the i-motif dimer of d(5mCCTTTACC): a noncanonical structure with possible roles in chromosome stability. Structure, 5, 1231-1246.
  2. Mergny J.L., Phan A.T., Lacroix L. (1998). Following G-quartet formation by UV-spectroscopy. FEBS letters, 435, 74 -78.
  3. Phan A.T., Leroy J.L., Guéron M. (1999). Determination of the residence time of water molecules hydrating B'-DNA and B-DNA, by the one-dimensional zero-enhancement nuclear Overhauser effect spectroscopy. J. Mol. Biol., 286, 505-519.
  4. Phan A.T., Guéron M., Leroy J.L. (2000). The solution structure and internal motions of a fragment of the cytidine-rich strand of the human telomere. J. Mol. Biol., 299, 123-144. (Cover article).
  5. Phan A.T. (2000). Long-range imino proton-13C J-couplings and the through-bond correlation of imino and non-exchangeable protons in unlabeled DNA. J. Biomol. NMR, 16, 175-178.
  6. Phan A.T. (2001). Through-bond correlation of sugar and base protons in unlabeled nucleic acids. J. Magn. Reson., 153, 223-226.
  7. Phan A.T., Mergny J.L. (2002). Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res., 30, 4618-4625.
  8. Phan A.T., Patel D.J. (2002). A site-specific low-enrichment 15N, 13C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids. J. Am. Chem. Soc., 124, 1160-1161.
  9. Phan A.T., Patel D.J. (2002). Differentiation between unlabeled and very-low-level fully 15N, 13C-labeled nucleotides for resonance assignments in nucleic acids. J. Biomol. NMR, 23, 257-262.
  10. Phan A.T., Patel D.J. (2003). Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: Distinct topologies, thermodynamic properties and folding/unfolding kinetics. J. Am. Chem. Soc., 125, 15021-15027.
  11. Phan A.T., Modi Y.S., Patel D.J. (2004). Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) sequence interconverts between asymmetric dimeric G-quadruplexes in solution. J. Mol. Biol., 338, 93-102.
  12. Phan A.T., Modi Y.S., Patel D.J. (2004). Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J. Am. Chem. Soc., 126, 8710-8716.
  13. Serganov A., Yuan Y.R., Pikovskaya O., Polonskaia A., Malinina L., Phan A.T., Hobartner C., Micura R., Breaker R.R., Patel D.J. (2004). Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem. Biol., 11, 1729-1741. (Cover article; News & Views in Chem. Biol., 2005 Jan, 12, 10-13; Review in Faculty 1000).
  14. Serganov A., Keiper S., Malinina L., Tereschko V., Skripkin E., Höbartner C., Polonskaia A., Phan A.T., Wombacher R., Micura R., Dauter Z., Jäschke A., Patel D.J. (2005). Structural basis for Diels-Alder ribozyme catalyzed carbon-carbon bond formation. Nat. Struct. Mol. Biol., 12, 218-224. (Cover article; News & Views in Nat. Struct. Mol. Biol., 2005 Mar, 12, 206-208; Review in Faculty 1000).
  15. Phan A.T., Kuryavyi V., Ma J.B., Faure A., Andréola M.L., Patel D.J. (2005). An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase. Proc. Natl. Acad. Sci. USA, 102, 634-639. (From the cover; Research Focus in Trends Biochem. Sci., 2005 May, 30, 231-234).
  16. Phan A.T., Kuryavyi V., Gaw H.Y., Patel D.J. (2005). Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nat. Chem. Biol., 1, 167-173. (Research Highlights in Nature, 2005 Jul, 436, 445; in Nat. Struct. Mol. Biol., 2005 Aug, 12, 644; in Nat. Rev. Cancer, 2005 Sep, 5, 669).
  17. Zhang N., Phan A.T., Patel D.J. (2005). (3+1) assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex. J. Am. Chem. Soc., 127, 17277-17285.
  18. Teplova M., Yuan Y.R., Phan A.T., Malinina L., Ilin S., Teplov A., Patel D.J. (2006). Structural basis for recognition and sequestration of UUUOH 3’ termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol. Cell, 21, 75-85. (Minireview in Mol. Cell, 2006 Jan, 21, 149-152; Research Focus in Trends Biochem. Sci., 2006 Jun, 31 , 303-305).
  19. Serganov A., Polonskaia A., Phan A.T., Breaker R.R., Patel D.J. (2006). Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature, 441, 1167-1171. (News & Views in Nature, 2006 Jun, 441, 1054-1055; Preview in Cell, 2006 Jul, 126, 19-22; Points of View in ACS Chemical Biology, 2006 Jul, 1, 341-345; Review in Faculty 1000).
  20. Luu K.N., Phan A.T., Kuryavyi V., Lacroix L., Patel D.J. (2006). Structure of the human telomere in K+ solution: an intramolecular (3+1) G-quadruplex scaffold. J. Am. Chem. Soc., 128, 9963-9970. (Science and Technology review in Chemical & Engineering News, 2006 Jul, 84 (31), 46; Review in Faculty 1000).
  21. Phan A.T., Luu K.N., Patel D.J. (2006). Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Res., 34, 5715-5719.
  22. Phan A.T., Kuryavyi V., Burge S., Neidle S., Patel D.J. (2007). Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J. Am. Chem. Soc., 129, 4386-4392. (Highlight in Cover Story of Chemical & Engineering News, 2007 May, 85 (22), 12-17; Review in Faculty 1000).
  23. Phan A.T., Kuryavyi V., Luu K.N., Patel D.J. (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Res., 35, 6517-6525.
  24. Amrane S., Ang R.W., Tan Z.M., Li C., Lim J.K., Lim J.M., Lim K.W., Phan A.T. (2009). A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence. Nucleic Acids Res., 37, 931-938.
  25. Lim K.W., Amrane S., Bouaziz S., Xu W., Mu Y., Patel D.J., Luu K.N., Phan A.T. (2009). Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J. Am. Chem. Soc., 131, 4301-4309. (Review in Faculty 1000).
  26. Martadinata H., Phan A.T. (2009). Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution. J. Am. Chem. Soc., 131, 2570-2578.
  27. Mendez-Bermudez A., Hills M., Pickett H.A., Phan A.T., Mergny J.L., Riou J.F., Roy N.J. (2009). Human telomeres that contain (CTAGGG)n repeats show replication instability in somatic cells and the male germline. Nucleic Acids Res., 37, 6225-6238. (Cover article).
  28. Lim K.W., Alberti P., Guédin A., Lacroix L., Riou J.F., Roy N.J., Mergny J.L., Phan A.T. (2009). Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G•C•G•C tetrad. Nucleic Acids Res., 37, 6239-6248. (Cover article).
  29. Hu L., Lim K.W., Bouaziz S., Phan A.T. (2009). Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: Effect of loop lengh and sequence on the folding topology. J. Am. Chem. Soc., 131, 16824-16831. (Review in Faculty 1000).
Review Articles
  1. Phan A.T., Leroy J.L. (2000). Intramolecular i-motif structures of telomeric DNA. J. Biomol. Struct. Dyn., Sp. Iss. S2, 245-251.
  2. Phan A.T., Guéron M., Leroy J.L. (2001). Investigation of unusual DNA motifs. Methods Enzymol., 338, 341-371.
  3. Phan A.T., Kuryavyi V., Patel D.J. (2006). DNA architecture: from G to Z. Curr. Opin. Struct. Biol., 16, 288-298.
  4. Patel D.J., Phan A.T., Kuryavyi V. (2007). Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res., 35, 7429-7455.
  5. Herbert B.S., Huppert J.L., Johnson F.B., Lane A.N., Phan A.T. (2009). Meeting report: Second international meeting on quadruplex DNA. Biochimie, 91, 1059-1065.
  6. Phan A.T. (2009). Human telomeric G-quadruplex: Structure of DNA and RNA sequences. FEBS J., in press.
Book Chapters
  1. Leroy J.L., Nonin S., Han X., Phan A.T., Guéron M. (1998). Switching and looping in i-motif structures. In Structure, Motion, Interaction and Expression of Biological Macromolecules (Sarma, R.H. & Sarma, M.H., eds.), Adenine Press, Vol.1, pp. 49-62.
  2. Phan A.T., Kuryavyi V., Luu K.N., Patel D.J. (2006). Structural diversity of G-quadruplex scaffolds. In Quadruplex Nucleic Acids (Neidle, S. & Balasubramanian, S., eds.), Royal Society of Chemistry U.K., pp. 81-99.

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