Professor LEUNG Pak Hing

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Journal Publications

1.       Leung PH, McLaughlin GM, Martin JWL, Wild SB, "Resolution involving metal complexation, Synthesis and resolution of (±)-2-mercaptoethyl)methylphenylarsine", Inorganic Chemistry, 1986, 25, 3392.

2.       Leung PH, McLaughlin GM, Martin JWL, Wild SB, "Diastereiosm in square-planar complexes of bidentate nickel, palladium and platinum containing asymmetric 2-mercaptoethyl-substituted tertiary arsines and phosphines", Inorganic Chemistry, 1986, 25, 3392.

3.       Kerr PG, Leung PH, Wild SB, "Optically active arsenic macrocycles. Stereospecific synthesis of enantiomers and diastereomers of 14-membered trans-As2S2 chelating macrocycles containing resolved asymmetric tertiary arsenic donors", J American Chem. Soc., 1987, 109, 4321.

4.       Bergens SH, Leung PH, Bosnich B, Rheingold AL, "Synthesis and structure of a biphenanthrol palladium complex displaying an unusual bonding mode", Organometallics, 1990, 9, 2406.

5.       Tan SF, Leung PH, Sin WC, "Catalytic autoxidation of p-anisaldehyde and styrene by a cobalt bis-schiff base complex", Transition Metal Chem., 1991, 16, 542.

6.       Chooi SYM, Leung PH Ng SC, Quek GH and Sim KY, "A Simple Route to Optically Pure 2,3-Diaminobutane", Tetrahedron Asymmetry, 1991, 2, 981.

7.       Chooi SYM, Hor TSA, Leung PH, Mok KF, "Stereochemical Investigations of Coordinated Sulfur Stereocenters. X-Ray Structure of Diastereomers of (–)-[Pd{(R)-CH3CH(1-C10H6)NMe2-C2N}{Ph2PCH2CH2SMe-P,S}]PF6", Inorganic Chemistry, 1992, 31, 1494.

8.       Leung PH, Willis AC, Wild SB, "Resolution involving metal complexation. Optical resolution and photochemical rearrangement of (±)-2-mercaptoethyl)methylphenylphosphine", Inorganic Chemistry, 1992, 31, 1406.

9.       Chooi SYM, Leung PH, Lim CC, Mok KF, Quek GH and Sim KY, Tan MK, "Versatile Chiral Palladium(II) Complexes for Enantiomeric Purities of 1,2-Diamines", Tetrahedron Asymmetry, 1992, 3, 529.

10.   Chooi SYM, Leung PH, Mok KF, "Palladium(II) and Platinum(II) Complexes with Chelating Sulfinyl Functions", Inorganica Chimica Acta, 1993, 205, 243.

11.   Chooi SYM, Siah SY, Leung PH, Mok KF, "Optical Resolution and Chelating Properties of (±)-(2-Methylsulfinyl)ethyl-diphenylarsine and Its phosphine Analogue", Inorganic Chemistry, 1993, 32, 4812.

12.   Zhou MS, Xu Y, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(µ-S)2(PPh3)4] as a metalloligand towards main group Lewis acids: A Mexican-hat-like structure for [Pt2Tl(µ3-S)2(PPh3)4]X (X = NO3, PF6) with a two coordinate angular Tl(I)", Inorganic Chemistry, 1993, 32, 1875.

13.   Zhou MS, Xu Y, Lam CF, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(µ-S)2(PPh3)4] as a metalloligand towards main group Lewis acids: Crystal structures of two complex adducts of lead nitrate, [(PPh3)4Pt2(µ3-S)2-Pb(NO3)2] and [(PPh3)4Pt2(µ3-S)2Pb(NO3)]PF6", Inorganic Chemistry, 1993, 32, 4660.

14.   Chooi SYM, Leung PH, Sim KY, Tan KS, Kon OL, "In Vitro Cytotoxic Properties of Gold(I) and Platinum(II) Compounds Containing Asymmetric (2-Methylsulfinyl)ethyl-diphenylarsine and Its phosphine Analogue", Tetrahedron Asymmetry, 1994, 5, 49.

15.   Chooi SYM, Tan MK, Leung PH, Mok KF, "Stereochemical Investigations of Bis(bidentate)-Palladium(II) Complexes. Transmission of Ring Chiralities Between Chelating Amine Ligands via Their Prochiral N-Methyl Substituents", Inorganic Chemistry, 1994, 33, 3096.

16.   Aw BH, Leung PH, "A Simple Route to An Optically Pure Diphosphine Ligand Containing a Phosphorus Stereogenic Centre", Tetrahedron Asymmetry, 1994, 5, 1167.

17.   Siah SY, Leung PH, Mok KF, "Palladium(II) and Platinum(II) Complexes with a Novel P-S(O)-P Tridentate Ligand", Polyhedron, 1994, 13, 3253.

18.   Chooi SYM, Ranford JD, Leung PH, Mok KF, "Stereoelectronic Effects on the Chelating Properties of (2-Methylsulfinyl)ethyl-diphenylarsine and Its phosphine Analogue", Tetrahedron Asymmetry, 1994, 5, 1805.

19.   Lim CC, Leung PH, Sim KY, "Resolution and Enantiomeric Purities of (2-Methylsulfinyl)ethylamine", Tetrahedron Asymmetry, 1994, 5, 1883.

20.   Zhou MS, Xu Y, Lam CF, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(µ-S)2(PPh3)4] as a metalloligand towards main group Lewis acids: The first square-pyramidal structure of an In(III) complex adduct in (PPh3)4Pt2(µ3-S)2InCl3 and tetrahedral Ga(III) in the ion-pair  [(PPh3)4Pt2(µ3-S)2GaCl2][GaCl4]", Inorganic Chemistry, 1994, 32, 1572.

21.   Zhou MS, Lam CF, Koh LL, Mok KF, Leung PH, Hor TSA, "Facile ligand transformation from bridging thio to terminal chloromethanethiolato. Bridge opening of [Pt(µ-S)(Dppf)]2 by dichloromethane to give Pt(SCH2Cl)2(dppf) [dppf = Fe(C5H4PPh2)2]", J. Organomet. Chem., 1994, 476.

22.   Chan SC, Koh LL, Leung PH, Ranford JD, Sim KY, "Copper(II) complexes of the antitumour related ligand salicylaldehyde acetylhydrazone (H2L) and the single crystal X-ray structures of [{Cu(HL)H2O}2]2(NO3)", Inorganica Chimica Acta, 1995, 236, 101.

23.   Zhou MS, Xu Y, Tan AM, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(dppf)2(µ-S)2] as a heterometallic ligand. Simple assembly of an electroactive interpolymetallic complex [Pt2Tl(dppf)2(µ3-S)2]X (X = NO3, PF6) (dppf = 1,1'-bis(diphenylphosphino)ferrocene)", Inorganic Chemistry, 1995, 34, 6425.

24.   Siah SY, Leung PH, and Mok KF, "Palladium Complex Catalysed Asymmetric Diels-Alder Reaction: Stereoselective synthesis of a New Sulfinyl-Substituted Phosphine Ligand Containing 3 Carbon, 1 Phosphorus and 1 Sulfur Stereogenic Centres", J. Chem. Soc., Chemical Communications, 1995, 1747.

25.   Quek, GH, Leung PH, Mok KF, "Stereoelectronic Properties of the Sulfinyl-Substituted Phosphine Ligands: Synthesis and X-Ray Structure of the Stable Complex [PtCl2{Ph2PCH2S(O)Me}{MeOH}]", Inorganica Chimica Acta, 1995, 239, 185.

26.   Loh SK, Mok KF, Leung, PH, White AJP and Williams DJ", A Simple Route to a Novel enantiomerically Pure P-Chiral Phosphine Ligand Containing a Tertiary Amide Functional Group", J. Chem Soc., Chemical Communications, 1996, 591.

27.   Siah SY, Leung PH, Mok KF, "1H NMR Studies of Palladium Complexes with Tridentate Chelates, E-S(O)-E (E = P, As) and their Novel Asymmetric Analogue", Polyhedron, 1996, 15, 3915.

28.   Selvaratnam S. Mok, K. F. Leung, PH, White AJP and Williams DJ, "A Simple and Efficient Approach to a Rigid Diphosphine Ligand Containing Two Phosphorus and Three Carbon Stereogenic Centers by Means of a Palladium Complex Promoted Asymmetric Diels Alder Reaction", Inorganic Chemistry, 1996, 35, 4798.

29.   Leung PH, Loh SK, Mok KF, White AJP, Williams DJ, "Asymmetric synthesis, structures and coordination chemistry of palladium(II) complexes containing a chiral P-S hybrid bidentate ligand", J. Chem. Soc., Dalton Trans., 1996, 4443.

30.   Aw BH,  Leung PH, White AJP, Williams DJ, "Asymmetric Synthesis of a P-chiral As-P bidentate ligand via an organopalladium complex promoted asymmetric Diels-Alder reaction between Ph2AsCH=CH2 and 1-phenyl-3,4-dimethylphosphole",  Organometallics, 1996, 15, 3640.

31.   Loh SK, Mok KF, Leung PH, White AJP, williams DJ, "Isolation and structural characterization of a reactive chiral palladium(II) complex containing a ClO4 ligand", Tetrahedron Asymmetry, 1996, 7, 45.

32.   Aw BH, Selvaratnam S., Leung PH, Rees NH, McFarlane, "NMR assignment of absolute configuration of a P-chiral diphosphine and mechanics of its stereoselective formation", Tetrahedron Asymmetry, 1996, 7, 1753.

33.   Cheng CR, Leung PH, Mok KF, " Synthesis and Characterization of a Nickel(II) Complex Containing a Tridentate Hybrid Ligand Containing Phosphorus and Sulfur", Polyhedron, 1996, 15, 1401.

34.   Zhou MS, Leung PH, Mok KF, Hor TSA, "[Pt2(PPh3)4(m3-S)2] as a metalloligand towards main-group Lewis acids",  Polyhedron, 1996, 15, 1737.

35.   Siah SY, Leung PH, Mok KF, Drew MGB, "A P-O chelation with palladium: Toward Understanding of the Stereochemistry of an Optically Active Sulfinyl-substituted Phosphine with five-stereogenic centres", Tetrahedron Asymmetry, 1996, 7, 357.

36.   Cheng CR, Leung PH, Mok KF, "Syntheses and Structures of Palladium(II) and Platinum(II) Complexes with tridentate (Ph2PCH2CH2CH2)2S and its arsenic analogue", Inorganica Chimica Acta, 1997, 260, 137.

37.   Aw BH, Hor TSA, Selvaratnam S, Mok KF, White AJP, Williams DJ, Rees NH, McFarlane W, "Asymmetric synthesis of P-chiral diphosphines. Steric effects on the palladium complex promoted asymmetric Diels-Alder reaction between dimethylphenylphosphole and (E/Z)-methyl substituted diphenylvinyl phosphines", Inorganic Chemistry, 1997, 36, 2138.

38.   Leung PH, Selvaratnam, Cheng CR, Mok KF, Rees NH, McFarlane W, "Asymmetric synthesis of a rigid diphosphine ligand containing two phosphorus and four carbon stereogenic centres by means of a chiral palladium complex promoted Diels-Alder reaction", J. Chem Soc., Chem Communications, 1997, 751.

39.   Zhou MS, Tan ALC, Xu Y, Lam CF, Leung PH, Mok KF, Koh LL, Hor TSA, "[Pt2(PPh3)4(m3-S)2] as a metalloligand toward main-group Lewis acids", Polyhedron, 1997, 16, 2381.

40.   Lim CC, Mok KF, Sim KY, Leung PH, "Palladium(II) and platinum(II) complexes containing dimesyloxy-substituted chiral diamines", Tetrahedron Asymmetry, 1997, 8, 2045.

41.   Liu AM, Mok KF, Leung PH, "Asymmetric synthesis of two diastereomeric P-chiral diphosphine ligands containing a pair of dissimilar asymmetric phosphorus donor atoms", J. Chem Soc., Chem Communications, 1997, 2397.

42.   Selvaratnam S, Leung PH, White AJP, Williams DJ, "Synthesis and absolute stereochemistry of an organopalladium complex containing a P-chiral diphosphine ligands", J. Organometallic Chemistry, 1997, 542, 61.

43.   Hockless DCR, Gugger, PA, Leung PH, Mayadunne RC, Pabel M, Wild SB, "Facile interconversion between diastereomers of chloro-bridged palladium(II) fimers of orthometallated (±)-dimethyl[1-(1-naphthyl)ethyl)]amine", Tetrahedron, 1997, 53, 4083.

44.   Leung PH, Loh SK, Vittal JJ, White AJP, Williams DJ, "Asymmetric synthesis of keto-substituted P-chiral phosphines by means of an unusual exo/endo-stereochemically controlled Diels-Alder reaction", J. Chem Soc., Chem. Communications, 1997, 1987.

45.   Leung PH, Siah SY, White AJP, William DJ, "Asymmetric synthesis, structures and reactions of palladium complexes containing thiolato and sulfinyl-substituted P-chiral phosphines", J. Chem. Soc., Dalton Trans., 1998, 893.

46.   Quek GH, Lang HF, Liu AM, Mok KF, White AJP, Rees NH, McFarlane w, Leung PH, "Optical resolution and stereoelectronic properties of chelating (±)-[(methylsulfinyl)methyl]diphenylphosphine", J. Chem. Soc., Dalton Trans., 1998, 1639.

47.   Song YC, Mok KF, Leung PH, Chan SH, "Palladium complex promoted asymmetric synthesis of a novel P-chiral diphosphine containing an ester functional group", Inorganic Chemistry, 1998, 36, 37, 6399.

48.   Loh SK, Vittal JJ, Leung PH, "1-methyl-2-vinyl-pyridine and 1-phenyl-3,4-dimethylphosphole: their coordination chemistries and reactivities in a chiral palladium complex promoted asymmetric Diels-Alder reaction", Tetrahedron Asymmetry, 1998, 9, 423.

49.   Leung PH, Lang HF, White AJP, William DJ, "Molecular recognition in the palladium complex promoted asymmetric synthesis of a keto-ester hetero-functionalized P-chiral phosphine", Tetrahedron Asymmetry, 1998, 9, 2961.

50.   He GS, Loh SK, Vittal JJ, Mok KF, Leung PH, "Palladium complex promoted asymmetric synthesis of stereo-isomeric P-chiral pyridylphosphines via an unusual exo-endo stereochemically controlled asymmetric Diels-Alder reaction between 2-vinylpyridine and coordinated 3,4-dimethyl-1,1-phenylphosphole", Organometallics, 1998, 17, 3931.

51.   Lang HF, Vittal JJ, Leung PH, "Metal template synthesis and coordination properties of a palladium complex containing a novel and stable imidazole-substituted phosphine C-P bidentate chelate", J. Chem. Soc., Dalton Trans., 1998, 2109.

52.   Song YC, Vittal JJ, Chan SH, Leung PH, "Molecular recognition in a palladium complex promoted asymmetric synthesis of a P-chiral heterodifunctionalized bidentate phosphine ligand", Organometallics, 1999, 18, 650.

53.   Lang HF, Leung PH, Rees NH, McFarlane W, "Stereochemical investigation of a kinetically labile chiral organopalladium complex in solution", Inorg. Chim. Acta, 1999, 284, 99.

54.   Leung PH, Liu AM, Mok KF, White AJP, Williams DJ, "Synthesis and coordination chemistry of a 14-membered macrocyclic ligand containing one phosphorus, two sulfur and one ambidentate sulfoxide donor sets", J. Chem. Soc., Dalton Trans., 1999, 1277.

55.   Song YC, Vittal JJ, Srinivasan N, Chan SH, Leung PH, "Synthesis and anti-cancer activities of a pair of enantiomeric gold(I) complexes containing sulfanyl-substituted P-chiral phosphine", Tetrahedron Asymmetry, 1999, 1433.

56.   Leung PH, Liu AM, Mok KF, "A versatile and efficient approach to enantiomerically pure monodentate and bidentate P-chiral phosphines", Tetrahedron Asymmetry, 1999, 1309.

57.   He GS, Mok KF, Leung PH, "Optical resolution, configurational stability and coordination chemistry of P-chiral heterocyclic diphosphine 1,1'-diphenyl-3,3',4,4'-tetramethyl-2,2'diphosphol-3,3'-ene", Organometallics, 1999, 18, 4027.

58.   Leung PH, Ng KH, Li YX, White AJP, Williams DJ, "Designer cyclopalladated amine catalysts for the asymmetric Claisen rearrangement", J. Chem Soc., Chem Communications, 1999, 2435.

59.   Leung PH, He GS, Lang HF, Liu AM, Loh SK, Selvaratnam, Mok KF, White AJP, Williams DJ, "Metal template synthesis and coordination chemistry of functionalized P-chiral phosphanorbornenes", Tetrahedron, 2000, 56, 7 (an invited publication in a special issue for the heterocycle chemistry).

60.   He G, Yang Q, Mok KF, Leung PH, "Metal ion effects on the asymmetric dimerization of 1-phenyl-3,4-dimethylphosphole", J Chem Soc., Chem. Communications, 2000, 167.

61.   Liu X, Mok KF, Leung PH, "Formation of imino-phosphine bidentate chelates by an unprecedented organopalladium complex promoted oxidative coupling reaction between diphenylphosphine and imines", Organometallics, 2000, 19, 3722.

62.   Leung PH, Lang HF, Zhang X, Selvaratnam S, Vittal JJ, "Asymmetric Synthesis and the novel retro Diels-Alder reaction of a P-chiral sulfonyl-substituted phosphanorbornene", Tetrahedron Asymmetry, 2000, 2261.

63.   Goh LY, Leong WK, Leung PH, Weng ZQ, Haiduc I., "Chemistry of cyclopentadienyl tricarbonylchromium dimer. Cleavage of bis(thiophosphinyl)disulfanes and bis(thiophosphoryl)disulfanes. Synthesis of CpCr(CO)2(S2PPh2) and CpCr(S2PPh2)2. X-ray crystal structure of CpCr(S2PPh2)2", J. Organometallic Chemistry, 2000, 607, 64.

64.   Liu X, Mok KF, Leung PH, "Metal template promoted hydroamination of ethynyphosphines and aniline. Asymmetric synthesis, coordination chemistry and the imine-enamine tautomerism of P-chiral iminophosphines", Organometallics, 2001, 20, 3918.

65.   Goh LY, Z. Weng, Leong WK, Leung PH, "C-S Bond Cleavages and C-C coupling in cyclopentadienylchromium complexes to give the first dithiooxamide-bridged and doubly dithiocarbamate-bridged double cubanes", Angew. Chem. Int. Ed. Engl., 2001, 40, 3235.

66.   Yeo WC, Vittal JJ, White AJP, Williams DJ, Leung PH, "Metal template effects on the asymmetric cycloaddition reaction between diphenyl-vinylphosphine and 2-diphenylphosphinofuran", Organometallics, 2001, 20, 2167.

67.   Leung PH, Qin Y, He GS, Mok KF, Vittal JJ, "Coordination chemistry, reactivities and stereoelectronic properties of chelating phosphine ligands containing thiomide substituents", J. Chem. Soc., Dalton Trans., 2001, 309.

68.   Liu X, Ong TKW, Vittal JJ, Leung PH, Selvasothi, Williams DJ, "Palladium(II) ion promoted hydroamination of di(phenylethynyl)phenylphosphine and Aniline: A facile synthesis of a six-membered P-N heterocycle", J. Organometallic Chemistry, 2002, 643, 4 (An invited publication).

69.   Qin Y, White AJP, Williams DJ, Leung PH, "Palladium complex promoted asymmetric hetero Diels-Alder reaction between a thiocarbonyl dienophile and a phospha-substituted cyclic diene", Organometallics, 2002, 21, 171.

70.   Goh LY, Weng Z, Leong WK, Leung PH, "A synthetic and structural study of some cyclopentadienylchromium dithiocarbamate complexes and their thermolytic derivatives", Organometallics, 2002, 21, 4398.

71.   Qin Y, Selvaratnam S, Vittal JJ, Leung PH, "Organopalladium complex promoted asymmetric cycloaddition reactions involving 3,4-dimethyl-1-phenylphosphole-1-sulfide as the hetero cyclic diene", Organometallics, 2002, 21, 5301.

72.   Li Y, Ng KH, Tan GK, Vittal JJ, Leung PH, "Design, synthesis and the stereoelectronic properties of cyclopalladated complexes derived from enantiomerically pure (R/S)-N,N-dimethyl-1-(9-phenantryl)ethylamine",  Organometallics, 2003, 22, 834.

73.   Teo TW, Selvarantnam, S, Vittal, JJ, Leung PH, "Asymmetric synthesis and coordination chemistry of a P-chiral diphosphine monoxide", Inorganica Chimica Acta, 2003, 352, 213. (an invited publication).

74.   Li YX, Selvaratnam S, Vittal, JJ, Leung PH, "A rational approach to the design and synthesis of chiral organopalladium-amine complexes", Inorganic Chemistry, 2003, 42, 3229.

75.   Qin Y, Lang F, Vittal, JJ, Tan GK, Selvaratnam S, White AJP, Williams DJ, Leung PH, "Asymmetric synthesis and coordination chemistry of bidentate P-stereogenic phosphines containing ester and thionoester functionalities", Organometallics, 2003, 22, 3944.

76.   Ng JKP, Tan GK, Vittal JJ, Leung PH, "Optical resolution and the study of ligand effects on the ortho-metallation reaction of resolved (±)-diphenyl[1-(1-naphthyl)ethyl]phosphines and its arsenic analogue", Inorganic Chemistry, 2003, 42, 7674.

77.   Leung PH, "Asymmetric synthesis and organometallic chemistry of functionalized phosphines containing stereogenic phosphorus centers", Accounts of Chemical Research 2004, 37, 169 (an invited publication).

78.   Yeo WC, Vittal JJ, Koh LL, Tan GK, Leung PH, "Chiral metal template promoted asymmetric pyrrole Diels-Alder reaction between N-(diphenylphosphino)pyrrole and diphenylvinylphosphine", Organometallics, 2004, 23, 3474.

79.   Liu X, Selvaratnam, Mok, KF, Leung PH, "The naphthylamine palladium(II) template induced E-Z isomeriosm of exocyclic vinyl group in five-membered P-N chelates: detailed spectroscopic studies", Inorganica Chimica Acta, 2004, 375, 4279.

80.   Yeo WC, Tee SY, Tan BH, Tan GK, Koh LL, Leung PH, "Chiral palladium template promoted asymmetric hydrophosphination reaction between diphenylphosphine and vinylphosphines", Inorganic Chemistry, 2004, 43, 8102.

81.   Loh SK, Selvaratnam S, Tan GK, Koh LL, Leung PH, "Organopalladium complex promoted asymmetric synthesis of a P-chiral phosphanorbornene in ionic liquids and in organic solvents", J. Organometallic Chemistry, 2005, 690 (21-22): 4933-4938.

82.   Yeo WC, Tang LL, Yan B, Tee SY, Koh LL, Tan GK, Leung PH, "Chiral metal template induced asymmetric synthesis of mixed phosphine-phosphine oxide ligand", Organometallics, 2005, 24 (23): 5581-5585.

83.   Yeo WC, Tan GK, Koh LL, Leung PH, “Asymmetric [2+2] cycloaddition of (E)-2-(diphenylphosphanyl)styrene promoted by a chiral metal template”, Eur. J. Inorg Chem., (23): 4723-4728 Dec 2005

84.   Ng JKP, Li YX, Tan GK, Koh LL, Vittal JJ, Leung PH, “Stereochemical investigations of a novel class of chiral phosphapalladacycle complexes derived from 1-[(2,5-dimethyl)phenyl]ethyldiphenylphosphine”, Inorg. Chem., 44 (26): 9874-9886 Dec 2005

85.   Yeo WC, Vittal JJ, Koh LL, Leung PH, “Functionalization of metal-protected chiral phosphines via simple organic transformations”, Organometallics, 25 (5): 1259-1269 Feb 2006

86.   Pullarkat SA, Tan KW, Ma M,  Leung PH et al., “Asymmetric synthesis of a P-chiral heteroditopic PP=S ligand via chiral metal template promoted cycloaddition between 3,4-dimethyl-1-phenylphosphole and its sulfonated analog”, J. Organomet. Chem, 691 (13): 3083-3088 Jun 2006

87.   Pullarkat SA, Yi D, Li YX, Leung Pak-Hing., "A novel approach toward asymmetric synthesis of alcohol functionalized C-chiral diphosphines via two-stage hydrophosphination of terminal alkynols"., Inorganic Chemistry., 45 (18): 7455-7463, 2006

88.   Tan, Kien-Wee; Liu, Fengli; Li, Yongxin; Tan, Geok-Kheng; Leung, Pak-Hing., "Asymmetric synthesis of a chiral arsinophosphine via a metal template promoted asymmetric Diels-Alder reaction between diphenylvinylphosphine and 2-furyldiphenylarsine",    Journal of Organometallic Chemistry",  691(22),  4753-4758,  2006

89.   Lulu Tang; Zhang Yi; Luo Ding; Li Yongxin; Mok Kum-Fun; Yeo Wee Chuan, Leung Pak-Hing, " Asymmetric synthesis of dimethyl-1,2-bis (diphenylphosphino)-1,2-ethanedicarboxylate by means of a chiral palladium template promoted hydrophosphination reaction", Tetrahedron Letters, 48, 33-35, 2007.

90.   Kok-Peng Ng, Shuli Chen, Pak-Hing Leung et. al., Substituent Effects on the Stereoelectronic and Chemical Properties of a Novel Phosphapalladacycle, Joseph  European Journal of Inorganic Chemistry, 3124-3134, 2007.

91.   Wee-Chuan Yeo, Shuli Chen, Pak-Hing Leung et. al., “Synthesis of P-Chiral Phosphines via Chiral Metal Template Promoted Asymmetric Furan Diels-Alder Reaction”.  Journal of Organometallic Chemistry, 692(12), 2539-2547, 2007.

92.   Joseph Kok-Peng Ng, Shuli Chen, Yongxin Li, Pak-Hing Leung et.al., “Cyclopalladation of the Prochiral (Di-tert-butyl)(diphenylmethyl)phosphine: Kinetic Lability of the Corresponding (+)-Phosphapalladacyclic Pd – C Bond and the Reluctance of the Phosphine to Bind in a Monodentate Fashion”.  Inorganic Chemistry, 46(12), 5100-5109, 2007.

93.   Maricar L. Bungabong, Kien Wee Tan, Yongxin Li, Selvasothi V. Selvaratnam, Krishna G. Dongol, Pak-Hing Leung A Novel Asymmetric Hydroarsination Reaction Promoted by Chiral Organo-Palladium Complex, Inorganic Chemistry, 46(11), 4733-4736, 2007.

94.   Joseph K. P. Ng, Shuli Chen, Geok K, and Pak-Hing Leung Conformational Analyses of the Five-membered Palladacycles Derived from 1-(1'-Naphthyl)ethyldiphenylphosphine and its Arsenic Analogue, Tetrahedron: Asymmetry, 18(10), 1163-1169, 2007.

95.   Mengtao Ma, Pullarkat S.A, Li Yongxin and Pak-Hing Leung., Novel Stereochemistry, Reactivity and Stability of an Arsenic Heterocycle in Metal Promoted Asymmetric Cycloaddition Reaction, Inorganic Chemistry, 46(22), 9488 – 9494, 2007

96.   Yi Zhang, Lulu Tang, Yi Ding, Jia-Hui Chua, Yongxin Li, Mingjun Yuan and Pak-Hing Leung., Base controlled (1,1)- and (1,2)-hydrophosphination of functionalized alkynes, Tetrahedron Letters, 49(11), 1762-1767, 2008.

97.   Yi Ding, Yongxin Li, Yi Zhang, Sumod A. Pullarkat, Pak-Hing Leung., Design, Synthesis and Stereochemical Evaluation of A Novel Chiral Amine-Palladacycle, European Journal of Inorganic Chemistry, 11 1880-1891, 2008.

98.   Mengtao Ma, Pullarkat S.A, Li Yongxin and Pak-Hing Leung., “Asymmetric synthesis of a chiral hetero-bidentate As-P ligand containing both As and Pstereogenic centres”, Journal of Organometallic Chemistry, 693, 3289, 2008.

99.   Ding Yi, Li Yongxin, Pullarkat S.A, See Leng Yap, Pak-Hing Leung, Rational Design of a Novel Chiral Palladacycle: Synthesis, Optical Resolution and Stereochemical Evaluation, European Journal of Inorganic Chemistry, 2, 267-276, 2009.

100.                        Y. Mingjun, S.A.Pullarkat, M.Mengtao, Y. Zhang, Y.Hunag, L.Yongxin, A.Goel and P.H.Leung, Asymmetric Synthesis of Functionalized 1,2- Diphosphine via the Chemoselective Hydrophosphination of Coordnated Allylic Phosphines, Organometallics,28(3), 780-786, 2009.

101.                        M. Mengtao, S.A.Pullarkat, K. Chen, L.Yongxin, P.H.Leung, Template Effects on the Asymmetric Cycloaddition between 3,4-dimethyl-1-phenylarsole and diphenylvinylphosphine and their Arsenic Elimination Reactions, J. Organomet. Chem., 2009, 694, 1929-1933.

102.                        Y. Zhang, S.A.Pullarkat, L. Yongxin and P.H. Leung, Asymmetric Synthesis of Diphosphine Ligands Containing Phosphorous and carbon Stereogenic Centers by Means of a Chiral Palladium Complex Promoted Hydrophosphination Reaction, Inorg. Chem., 2009, 48(12), 5535-5539.

103.                        S.A.Pullarkat, Y.L. Cheow, L.Yongxin and P.H.Leung, Enantioselective High Yield Synthesis of Alcohol Functionalized Diphosphines Utilizing Asymmetric Control via a Chiral Auxilliary, European Journal of Inorganic Chemistry, 2009, 16, 2375-2382.

104.                         Y. Mingjun, S.A.Pullarkat, C.H. Yeong, L. Yongxin, D. Krishnan and P.H.Leung, Controllable Synthesis of P-chiral 1,2- and 1,3-diphosphines via asymmetric Diels-Alder Reactions Involving Functionalized Allylic Phosphines as Dienophiles, Dalton Trans., 2009, 3668-3670.

105.                        F. Liu, S.A.Pullarkat, L. Yongxin, S. Chen, Y. Mingjun, Z.Y.Lee and P.H.Leung, Highly Enantioselective Synthesis of (2-Pyridyl)phosphine based C-chiral Unsymmetrical P,N Ligands using a Chiral Palladium Complex, Organometallics, 2009, 28(13), 3941-3946.

106.                         F.Liu, S.A.Pullarkat, L.Yongxin, S.Chen and P.H.Leung, Novel Enantioselective synthesis of functionalized pyridylarsines by a chiral palladium template promoted asymmetric hydroarsination reaction, Eur. J. Inorg. Chem., 2009, 27, 4134-4140.  

107.                        Y.Zhang, L.Tang, S.A. Pullarkat, F. Liu, L. Yongxin and P.H.Leung, Asymmetric synthesis of 1,2-bis(diphenylphosphino)-1-phenylehane via a chiral palladium template promoted hydrophosphination reaction, J. Organomet. Chem., 2009, 21(694), 3500-3505.

108.                        Y.Ding, M.Chaing, S.A.Pullarkat, L. Yongxin and P.H.Leung, Synthesis, Coordination Characteristics, Conformational Behaviour and Bond Reactivity Studies of a Novel Chiral Phosphapalladacycle Complex, Organometallics, 2009, 28(15), 4358-4370.

109.                        M.Mengtao, S.A.Pullarkat, Y.Mingjun, N,Zhang, L.Yongxin and P.H.Leung, Metal Effects on the Asymmetric Cycloaddition Reaction between 3,4-Dimethyl-1-phenylarsole and Diphenylvinylphosphinne Oxide, Organometallics, 2009, 28(16), 4886-4889.

110.                        D. Luo, Y. Li, K-W Tan, and P.H. Leung, Stepwise Functionalization of Two Alkyne Moieties in a Dialkynylphosphine Complex Leading to the Formation of a Bifunctionalized Phosphine Complex Bearing a Stereogenic Center at Phosphorus, Organometallics, accepted for publication.

Conference Publications

1.       Chooi SYM, Leung PH, Hor TSA, "Stereochemistry of coordinated sulfur donors", The 4th Asian Chemical Congress, 26-30 August 1991, Beijing, PR China, page 552: Beijing International Convention Centre, 1991.

2.       Leung PH, Mok KF, Tan MK, "Crystal structures of three diastereomeric complexes from [1-[1-(dimethylamino)-ethyl]-2-naphthlenyl-C,N] and N,N,N',N'-tetramethyl-2,3-butanediamine", XVI Congress and General Assembly International Union of Crystallography, 21-29 August 1993, Beijing, China.

3.       Hor TSA, Koh LL, Lam CF, Leung PH, Mok KF, Xu Y, Zhou MS, "[Pt2(u-S)2(PPh3)4] as a metalloligand towards main group Lewis acids", The 206th ACS National Meeting, Division of Inorganic Chemistry, 22-27 August 1993, Chicago, USA.

4.       Leung PH, "Stereochemistry and applications of palladium(II) complexes containingf ortho-metalated (R/S)-(1-(dimethylamino)ethyl)naphthalene", Recent Advanced in Inorganic and Organometallic Chemistry, 5-6 December 1994, Tokyo University, Japan.

5.       Siah SY, Leung PH, "Synthesis of optically active sulfinyl-substituted phosphines with five stereogenic centres and their ligand transformation to the thiolato analogue", The 31st International Conference on Coordination Chemistry, 18-23 August 1996, Vancouver, Canada, proceeding page 175: The University of British Columbia, 1996.

6.       Leung PH, "Stereochemistry and application of palladium(II) complexes containing ortho-metallated (R/S)-1-[1-(dimehtylamino)ethyl]naphthalene", The 2nd International Symposium on Organometallic Chemistry and Catalysis, IL19, 15-18 October 1996, Fuzhou, China, page 33-34: Institute of Chemistry, Academia SINICA.

7.       Leung PH and Selvaratnam, "Application of 2-D ROESY NMR in stereoinorganic chemistry", In proceeding of the First Asia Pacific International Symposium on Capillary Electrophoresis and other Nano- and Micro-scale Analytical Techniques, 17-20 December 1996, page 32: Institute of Material Research and Engineering, Singapore.

8.       Leung PH, "Palladium complex promoted asymmetric synthesis of functionalized P-chiral phosphines", Symposium on Frontiers of Chemistry, 20-23 December 1997, page 297-298: The Hong Kong University of Science and Technology, Hong Kong.

9.       Leung PH, Liu AM, Mok KF, "Combining the beauty of chiral recognition kinetic resolution and asymmetric synthesis in one simple reaction", The 3rd International Symposium on Organic-Metals, Metal Complexes and Catalysis, 10-13 August 1998, Harbin, PR China, pp 92-93: Institute of Chemistry, Academia SINICA.

10.   Leung PH, Vittal JJ, Chan SH, Song YC, "Looking into the structural chemistry of optically active gold(I) cluster", The 3rd International Symposium on Organic-Metals, Metal Complexes and Catalysis, 10-13 August 1998, Harbin, PR China, pp 106-107: Institute of Chemistry, Academia SINICA.

11.   Leung PH, "Cyclopalladated complex promoted asymmetric synthesis of functionalized P-chiral phosphines", The 3rd International Symposium on Organic-Metals, Metal Complexes and Catalysis, 10-13 August 1998, Harbin, PR China, pp 36-37: Institute of Chemistry, Academia SINICA.

12.   Leung PH, "Palladium complex promoted asymmetric synthesis of functionalized P-chiral phosphines", NUS Chem-UT/TIT Symposium on Organic Synthesis, 21 October 1998, National University of Singapore.

13.   Song YC, Chan SH, Leung PHm "Looking into the structural chemistry of optically active gold(I) cluster", 1st Singapore Chemical Conference, 7-9 December 1998, pp77-98, Singapore National Institute of Chemistry, Singapore.

14.   Leung PH, Lang HF, "A simple route to an enantiomerically pure P-chiral phosphine ligand containing four carbon and one phosphorus stereogenic centres", First Singapore Chemical Conference, 7-9 December 1998, pp 72-73, Singapore National Institute of Chemistry.

15.   Leung PH, He GS, "Synthesis and absolute stereochemistry of organopalladium complexes obtained from asymmetric Diels-Alder reaction", First Singapore Chemical Conference, 7-9 December 1998, pp 226-227, Singapore National Institute of Chemistry.

16.   Leung PH, "Design, synthesis and application of chiral organometallic complexes", The 4th International Symposium on Organic-Metals, Metal Complexes and Catalysis, 30 July – 2 August 1999, Lanzhou, PR China, pp 84-85: Institute of Chemistry, Academia SINICA.

17.   Ng KH, Leung PH, "Chiral cyclopalladated complexes catalysed Claisens rearrangement", The 34th International Conference on Coordination Chemistry, 9-14 July 2000, Edinburgh, The Royal Society of Chemistry, Dalton Division, UK.

18.   Leung PH, "Design, synthesis and application of chiral organopalladium(II) complexes", The 34th International Conference on Coordination Chemistry, 9-14 July 2000, Edinburgh, The Royal Society of Chemistry, Dalton Division, UK.

19.   Liu X, Leung PH, "First asymmetric hetero Diels-Alder reaction between 3,4-dimethyl-1-phenylphosphole and two prochiral imines under the promotion of an organopalladium auxiliary", The 2000 International Chemical Congress of Pacific Basin Societies, 14-19 December 2000, Honolulu, Hawaii, pp 886: American Chemical Society, USA.

20.   Leung PH, "Design, synthesis and application of chiral organopalladium(II) complexes", The 2000 International Chemical Congress of Pacific Basin Societies, 14-19 December 2000, Honolulu, Hawaii, pp 1155: American Chemical Society, USA.

21.   Liu XM, Mok KF, Vittal JJ, Leung PH, "Palladium(II) promoted synthesis of P-chiral iminophosphines by the hydroamination of phosphino alkynes", The 221st ACS National Meeting, 1-5 April 2001, San Diego, California, pp 77: American Chemical Society, USA.

22.   Liu X, Mok KF, Vittal JJ, Leung PH, "Palladium(II) template promoted synthesis of iminophosphines", Te 10th International Symposium on Relations between Homogenous and Heterogenous Catalysis, 2-6 July 2001, CPE Lyon, pp 122: French Chemical Society, France.

23.   Lim CE, Leung PH, "Chiral metal template promoted Diels-Alder reaction: the effect of soft metal ions in the dienes on the reaction with dienophiles containing the hard oxygen donor atoms", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 283: Singapore National Institute of Chemistry, Singapore.

24.   Liu X, Leung PH, "Palladium(II) template promoted asymmetric Diels-Alder reaction between DMPP and prochiral imines", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 295: Singapore National Institute of Chemistry, Singapore.

25.   Li Y, Vittal JJ, Leung PH, "Rational design, synthesis and optical resolution of a novel chiral organopalladium-amine complex", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 299: Singapore National Institute of Chemistry, Singapore.

26.   Ng KP, Leung PH, "Novel optical active C*-chiral palladacycles derived from 1-(1-naphthyl)ethyldiphenyl-phosphine and 1-(1-naphthyl)ethyldiphenylarsine ligands", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 308: Singapore National Institute of Chemistry, Singapore.

27.   Qin Y, Leung PH, "Synthesis of sulfur-sulfur bidentate chelates by organopalladium complex promoted hetero Diels-Alder reaction between DMPP and thioketones", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 314: Singapore National Institute of Chemistry, Singapore.

28.   Tan KW, Leung PH, "Different role of palladium(II) reaction promoter containing the ortho-palladated N,N-dimethylethylbenzylamine and the naphthylamine in reaction with phosphinoalkyne", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 329: Singapore National Institute of Chemistry, Singapore.

29.   Teo TW, Leung PH, "Highly efficient asymmetric synthesis of bidentate phosphine-phosphine oxide ligands promoted by chiral naphthyl-palladium complex", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 339: Singapore National Institute of Chemistry, Singapore.

30.   Leung PH, "A rational approach to the design, synthesis and application of chiral ortho-metallated benzyl- and naphthylamine complexes", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 120: Singapore National Institute of Chemistry, Singapore.

31.   Pullarkat SA, Teo TW, Leung PH, "Palladium(II) complex promoted asymmetric Diels-Alder reaction involving DMPP and DMPP=S", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 120: Singapore National Institute of Chemistry, Singapore.

32.   Yeo WC, Leung PH, "Synthesis and modification of chiral phosphines obtained by metal template promoted asymmetric Diels-Alder reaction between poor dienes and dienophiles", Singapore International Chemical Conference-II, 18-20 December 2001, Singapore, pp 120: Singapore National Institute of Chemistry, Singapore.

33.   Ng JKP, Leung PH, "Preparation and stereoelectronic properties of a novel optically active C*-chiral phosphapalladacyclic complex", The 8th International Conference on the Chemistry of the Platinum Group Metals, 7-12 July 2002, University of Southampton, pp 9: Royal Society of Chemistry, UK.

34.   Yeo WC, Leung PH, "Synthesis of chiral aminophosphine using metal assisted asymmetric Diels-Alder reaction", The 8th International Conference on the Chemistry of the Platinum Group Metals, 7-12 July 2002, University of Southampton, pp 42: Royal Society of Chemistry, UK.

35.   Leung PH, "Asymmetric synthesis of functionalized P-chiral phosphine supporters for gold anti-cancer drugs", In proceeding of the First Chemistry-IMRE Symposium, 10 September 2002, Singapore, pp 10: National University of Singapore, Singapore.

36.   Ng JKP, Leung PH, "Preparation and stereoelectronic properties of a novel optically active C*-chiral phosphaladacycle complex", The First Chemistry-IMRE Symposium, 10 September 2002, Singapore, poster presentation, National University of Singapore, Singapore.

37.   Yeo WC, Leung PH, "Synthesis of chiral aminophosphine using metal assisted asymmetric Diels-Alder reaction", The First Chemistry-IMRE Symposium, 10 September 2002, Singapore, poster presentation, National University of Singapore, Singapore.

38.   Pullarkat SA, Leung PH, "Organopalladium complex promoted asymmetric hetero Diels-Alder reaction involving DMPP=S", The First Chemistry-IMRE Symposium, 10 September 2002, Singapore, poster presentation, National University of Singapore, Singapore.

39.   Leung PH, "Activation of double and triple bonds by using chiral metal complexes", The 1st International Symposium on Biotechnology, Metal Complexes and Catalysis, 24-27 November 2002, Haikou, PR China, Institute of Chemistry, Academia SINICA.

40.   Leung PH, "Asymmetric synthesis of functionalized P-chiral phosphines supporters for gold anti-cancer drugs", The 3rd Singapore-India Collaborative and Cooperative Symposium, pp 34, 2-3 December 2002, Singapore.

41.   Leung PH, "Activation of double and triple bonds by chiral organometallic complexes", The 2nd Symposium on Scientific Collaborations in Catalysis Research, pp8, 12 December 2002, Eindhoven, The Netherlands, Eindhoven University of Technology.

42.   Pullarkat SA, Leung PH, "Asymmetric hydrophosphination and Diels-Alder reactions of phosphinoalkenes assisted by palladium(II) and platinum(II) complexes", The 6th Dalton Discussion on Organometallic Chemistry and Catalysis, 9-11 September 2003, University of York, pp 46: Royal Society of Chemistry, UK.

43.   Tan KW, Leung PH, "Insertion of phosphinoalkyne into Pt-C and Pd-C bonds", The 6th Dalton Discussion on Organometallic Chemistry and Catalysis, 9-11 September 2003, University of York, pp 45: Royal Society of Chemistry, UK.

44.   Leung PH, "Application and reactivity of chiral organometallic Ar-M complexes", The 2nd Singapore-China Collaborative and Cooperative Symposium, 6-10 April 2004, SooChow University, PR China.

45.   Leung PH, "Application and reactivity of chiral organometallic Ar-M complexes", The 36th International Conference on Coordination Chemistry, 18-23 July 2004, Merida Yucatan, Mexico.

46.   Leung PH, "Asymmetric Synthesis of functionalized P-chiral phosphines and development of gold anti-cancer drugs", International Symposium on Catalysis and Fine Chemicals 2004 (C&FC 2004), 12-15 December 2004, The Hong Kong Polytechnic University, Hong Kong.

47.   Leung PH, "Asymmetric Synthesis of functionalized P-chiral phosphines and development of gold anti-cancer drugs", Post Education and Research Programme in Chemistry (PERCH) Congress IV, 8-11 May 2005, Pattaya, Thailand.

48.   Leung PH, "Applications and Reactivities of Chiral Organometallic Ar -M Complexes", Singapore International Chemistry Conference 4 (SICC-4), 8 December 2005, Shangri-La Hotel, Singapore.

49.   Leung PH, "Activation of vinyl- and alkynyl-arsines and phosphines by chiral organometallic complexes”, Pacifichem 2005, 15-20 December 2005, Honolulu, Hawaii, USA.

50.   Leung PH, “Activation of Vinyl- and Alkenyl Phosphine and Arsine Bichiral Organometallic Complexes”, 1st Penang International Conference for Young Chemists (ICYC), 24-27 May 2006, Universiti Sains Malaysia, Penang, Malaysia.

51.   Leung PH, "Asymmetric Reactions Involving Heterocyclic Pyrroles, Phospholes and Arsoles", Post Education and Research Programme in Chemistry (PERCH) Congress V, 6-9 May 2007, Pattaya City, Chonburi, Thailand.

 

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