Single-Molecule and Applied Spectroscopy Laboratory is interested in
understanding fundamental and important processes occurring in Materials Chemistry,
Polymer Physics, Nanotechnology and Biological Chemistry at the
single-molecule level. We use single-molecule detection and applied
spectroscopy techniques in our research and are constantly developing new
techniques with greater sensitivity.
Materials Chemistry and Polymer Physics
The effects of confinement
on the properties of thin polymeric films are of great importance.
However, the nature of such effects remains relatively unknown.
Single-(macro)-molecule tracking via
wide-field fluorescence microscopy is used to study fundamental physical
processes such as crystallization, phase separation, wetting/dewetting of thin polymeric films. A better insight
into the effects of confinement and substrate-polymer interaction is
obtained by visualizing these processes in real-time.
microscopy images of a poly(ethylene oxide) sample maintained at 45oC
for (a) 35 h, (b) 47 h, and (c) > 65 h
Nanotechnology and Light-Induced Devices
We are interested in
understanding the driving force behind light-induced molecular devices at
the single-molecule level. In particular, a pertinent question that the
group wishes to address is the driving force behind the charge-recombination
process found in solar cells.
transport of the injected electron on TiO2 nanoparticle
after its transfer from single Atto647N dye molecules encapsulated in
cucurbituril gives rise to long-lived dark
charge-separated states that are directly probed using the fluorescence
intermittency of the emission intensity trajectories
In collaboration with Dr.
Bengang Xing (CBC), we will tackle the problem of bacterial resistance
against antibiotics. Single-molecule detection techniques such as
wide-field microscopy, super-resolution imaging and fluorescence
correlation spectroscopy are employed to understand the mode of
interaction between antibiotic drugs and bacterial. This study will have
important implications in drug design.