Associate Professor Kathy Qian Luo

Yu, Y . , Hong, Y . N . , Feng C . , Liu, J . Z . , Lam J . W . Y . , Faisal M . , Ng, K . M . , Luo, K . Q . and Tang, B . Z. (2009) Synthesis of an AIE-active fluorogen and its application in cell imaging. Science in China Series B: Chemistry, 52: 1-5.
Han, Q . B . , Zhou, Y . , Feng, C . , Xu, G . , Li, S . L . , Qiao, C . F . , Song, J . Z . , Chang, D .C ., Luo , K . Q . and Xu, H.X. (2009) Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/e lectrospray ionization quadrupole time-of-flight mass spectrometry. Journal of Chromatography B Analyt Technol Biomed Life Sci . 877:401- 40 7.
Huang, S . X . , Feng, C . , Zhou, Y . , Xu, G . , Han, Q . B . , Qian, C . F ., Chang, D . C . , Luo , K . Q . and Xu, H . X. (2009) Bioassay - guided isolation of xanthones and polycyclic polyprenylated acylphloroglucinols from Garcinia oblongifolia . Journal of Natural Products, 72:130-135 .
Han, Q . B . , Tian, H .L. , Yang, N . Y . , Qiao, C . F . , Song, J . Z . , Chang, D . C . , Luo, K . Q . and Xu, H . X. (200 8 ) Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells. Chemistry & Biodiversity, 5: 2710-2717 .
Xu, G . , Feng, C . , Zhou, Y . , Han, Q . B . , Qian, C . F ., Huang, S . X . , Chang, D . C . , Zhao, Q . S . , Luo , K . Q . and Xu, H . X. (200 8 ) Bioassay and ultraperformance liquid chromatograph/mass spectrometry g uided i solation of a poptosis-inducing b enzophenones and x anthones from the pericarp of Garcinia yunnanensis Hu, Journal of Agricultural and Food Chemistry , 56:11144-11150 .
Zhou, L., Chan, W.K., Xu, N., Xiao, K., Luo, H., Luo, K.Q. and Chang, D.C. (2008) Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sciences, 83:394-403.
Han, Q.B., Yang, N.Y., Tian, H., Qiao, C.F., Song, J.Z., Chang, D.C., Chen, S.L., Luo K.Q. and Xu, H.X. (2008) Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis. Phytochemistry , 69:2187-2192.
Zhang, E. J., Ng, K.M. and Luo, K.Q. (200 8 ) Response to Comment on Extraction and Purification of Isoflavones from Soybeans and Characterization of Their Estrogenic Activities . Journal of Agricultural and Food Chemistry , 56 : 3428 - 3430 .
Wei, B., Cheng, I . , Luo, K . Q. and Mi, Y . (2007) Capture and release of protein by a reversible DNA-induced sol-gel transition system. Angewandte Chemie-International Edition, 120:337-339.
Zhang, J., Ng, K.M. and Luo, K.Q. (2007) Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry , 55: 6940-6950 .
Tian, H., Ip, L., Luo, H. , Chang, D.C. and Luo, K.Q. (2007) A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. British Journal of Pharmacology, 150:321-334.
Harjo, B., Wibowo, C., Zhang, E.J.N., Luo, K.Q. and Ng, K.M. (2007) Development of process alternatives for separation and purification of isoflavones . Industrial & Engineering Chemistry Research, 46: 181-189.
Zhou, L.L., Zhou, L.Y., Luo, K.Q. and Chang, D.C. (2005) Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis, 10:289-299 .
Luo, K.Q. and Chang, D.C. (2004) The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the target region. Bioche mical and Biophys ical Re search Commun ications, 318:303-310.
Chang , D.C., Xu, N.H. and Luo, K.Q. (2003) Degradation of cyclin B is required for the onset of anaphase in mammalian cells. J ournal of Bio logical Chem istry, 278:37865-37873.
Luo, K.Q., Elsasser, S., Chang, D.C. and Campbell, J.L. (2003) Regulation of the localization and stability of Cdc6 in living yeast cells. Bioche mical and Biophys ical Re search Commun ications, 306:851-859.
Xu , N.H., Luo, K.Q. and Chang, D.C. (2003) Ca 2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint. Bioche mical and Biophys ical Re search Commun ications, 306:737-745.
Luo, K.Q., Yu, V., Pu, Y.M. and Chang, D.C. (2003) Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFα-induced apoptosis. Bioche mical and Biophys ical Re search Commun ications, 304:217-222.
Pu, Y.M., Luo, K.Q. and Chang, D.C. (2002) A Ca 2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells. Bioche mical and Biophys ical Re search Commun ications, 299:762-769.
Gao, W.H., Pu, Y.M., Luo, K.Q. and Chang, D.C. (2001) Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. J ournal of Cell Sci ence, 114:2855-2862.
Luo, K.Q., Yu, V., Pu, Y.M. and Chang, D.C. (2001) Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Bioche mical and Biophys ical Re search Commun ications, 283:1054-1060.
Michaelis, C., Luo, Q. and Weeks, G. (1995) A Dictyostelium discoideum gene, which is highly related to mo15 from Xenopus, is expressed during growth but not during development. Biochemistry and Cell Biology, 73:51-58.
Luo, Q., Michaelis, C. and Weeks, G. (1995) Cyclin B and Cdc2 expression and Cdc2 activity during Dictyostelium differentiation. DNA and Cell Biology, 14:901-908.
Luo, Q., Michaelis, C. and Weeks, G. (1994) Overexpression of a truncated cyclin B gene arrests Dictyostelium cell division during mitosis. J ournal of Cell Sci ence, 107:3105-3114 .
Schlech, W.F. III, Luo, Q., Faulkner, G. and Galsworthy, S. (1994) Interaction of Listeria species with human cell monolayers. Clinical and Inves tigative Medicine, 17:9-17.
Bessesen, M., Luo, Q., Rotbart, H.A., Blaser, M.J. and Ellison, R.T. III. (1990)Detection of Listeria monocytogenes by using the Polymerase Chain Reaction. Applied and Environmental Microbiology, 56:2930-2932.
Ellison, R.T. III, Luo, Q. and Reller, L.B. (1990) Enhancement of the activity of cefotaxime by iron-binding proteins. J ournal of Antimicrobial Chemotherapy, 25:479-481.

	Associate Professor Kathy Qian Luo
	Division of Bioengineering Nanyang Technological University N1.3-B3-09, 70 Nanyang Drive Singapore 637457 Tel: (65) 6790 4257 Fax: (65) 6791 1761 Email: Kluo@ntu.edu.sg
	Education:
	1990-1995 Ph.D. The University of British Columbia, Department of Microbiology and Immunology, Vancouver , Canada 1982-1985 M . S . Peking University, Department of Biology, Beijing , China 1978-1982 B . S . Peking University, Department of Biology, Beijing , China

	Research focus:
	Drug discovery: Using biosensor-based high throughput assays to discover novel anticancer drugs from Chinese herbal medicines. Pharmaceutical engineering: Studying the molecular mechanisms of apoptosis induced by anti-cancer drugs and pharmacokinetics of drug candidates using cancer cell lines and animal models. Nanomedicine: Using nanotechnology to enhance the solubility and bioavailability of the lead compounds and evaluating the resulting particles using a Caco-2 cell monolayer model and animal models.

	Selected publications:
	Yu, Y . , Hong, Y . N . , Feng C . , Liu, J . Z . , Lam J . W . Y . , Faisal M . , Ng, K . M . , Luo, K . Q . and Tang, B . Z. (2009) Synthesis of an AIE-active fluorogen and its application in cell imaging. Science in China Series B: Chemistry, 52: 1-5. Han, Q . B . , Zhou, Y . , Feng, C . , Xu, G . , Li, S . L . , Qiao, C . F . , Song, J . Z . , Chang, D .C ., Luo , K . Q . and Xu, H.X. (2009) Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/e lectrospray ionization quadrupole time-of-flight mass spectrometry. Journal of Chromatography B Analyt Technol Biomed Life Sci . 877:401- 40 7. Huang, S . X . , Feng, C . , Zhou, Y . , Xu, G . , Han, Q . B . , Qian, C . F ., Chang, D . C . , Luo , K . Q . and Xu, H . X. (2009) Bioassay - guided isolation of xanthones and polycyclic polyprenylated acylphloroglucinols from Garcinia oblongifolia . Journal of Natural Products, 72:130-135 . Han, Q . B . , Tian, H .L. , Yang, N . Y . , Qiao, C . F . , Song, J . Z . , Chang, D . C . , Luo, K . Q . and Xu, H . X. (200 8 ) Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells. Chemistry & Biodiversity, 5: 2710-2717 . Xu, G . , Feng, C . , Zhou, Y . , Han, Q . B . , Qian, C . F ., Huang, S . X . , Chang, D . C . , Zhao, Q . S . , Luo , K . Q . and Xu, H . X. (200 8 ) Bioassay and ultraperformance liquid chromatograph/mass spectrometry g uided i solation of a poptosis-inducing b enzophenones and x anthones from the pericarp of Garcinia yunnanensis Hu, Journal of Agricultural and Food Chemistry , 56:11144-11150 . Zhou, L., Chan, W.K., Xu, N., Xiao, K., Luo, H., Luo, K.Q. and Chang, D.C. (2008) Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sciences, 83:394-403. Han, Q.B., Yang, N.Y., Tian, H., Qiao, C.F., Song, J.Z., Chang, D.C., Chen, S.L., Luo K.Q. and Xu, H.X. (2008) Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis. Phytochemistry , 69:2187-2192. Zhang, E. J., Ng, K.M. and Luo, K.Q. (200 8 ) Response to Comment on Extraction and Purification of Isoflavones from Soybeans and Characterization of Their Estrogenic Activities . Journal of Agricultural and Food Chemistry , 56 : 3428 - 3430 . Wei, B., Cheng, I . , Luo, K . Q. and Mi, Y . (2007) Capture and release of protein by a reversible DNA-induced sol-gel transition system. Angewandte Chemie-International Edition, 120:337-339. Zhang, J., Ng, K.M. and Luo, K.Q. (2007) Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry , 55: 6940-6950 . Tian, H., Ip, L., Luo, H. , Chang, D.C. and Luo, K.Q. (2007) A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. British Journal of Pharmacology, 150:321-334. Harjo, B., Wibowo, C., Zhang, E.J.N., Luo, K.Q. and Ng, K.M. (2007) Development of process alternatives for separation and purification of isoflavones . Industrial & Engineering Chemistry Research, 46: 181-189. Zhou, L.L., Zhou, L.Y., Luo, K.Q. and Chang, D.C. (2005) Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis. Apoptosis, 10:289-299 . Luo, K.Q. and Chang, D.C. (2004) The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the target region. Bioche mical and Biophys ical Re search Commun ications, 318:303-310. Chang , D.C., Xu, N.H. and Luo, K.Q. (2003) Degradation of cyclin B is required for the onset of anaphase in mammalian cells. J ournal of Bio logical Chem istry, 278:37865-37873. Luo, K.Q., Elsasser, S., Chang, D.C. and Campbell, J.L. (2003) Regulation of the localization and stability of Cdc6 in living yeast cells. Bioche mical and Biophys ical Re search Commun ications, 306:851-859. Xu , N.H., Luo, K.Q. and Chang, D.C. (2003) Ca 2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint. Bioche mical and Biophys ical Re search Commun ications, 306:737-745. Luo, K.Q., Yu, V., Pu, Y.M. and Chang, D.C. (2003) Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFα-induced apoptosis. Bioche mical and Biophys ical Re search Commun ications, 304:217-222. Pu, Y.M., Luo, K.Q. and Chang, D.C. (2002) A Ca 2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells. Bioche mical and Biophys ical Re search Commun ications, 299:762-769. Gao, W.H., Pu, Y.M., Luo, K.Q. and Chang, D.C. (2001) Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. J ournal of Cell Sci ence, 114:2855-2862. Luo, K.Q., Yu, V., Pu, Y.M. and Chang, D.C. (2001) Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Bioche mical and Biophys ical Re search Commun ications, 283:1054-1060. Michaelis, C., Luo, Q. and Weeks, G. (1995) A Dictyostelium discoideum gene, which is highly related to mo15 from Xenopus, is expressed during growth but not during development. Biochemistry and Cell Biology, 73:51-58. Luo, Q., Michaelis, C. and Weeks, G. (1995) Cyclin B and Cdc2 expression and Cdc2 activity during Dictyostelium differentiation. DNA and Cell Biology, 14:901-908. Luo, Q., Michaelis, C. and Weeks, G. (1994) Overexpression of a truncated cyclin B gene arrests Dictyostelium cell division during mitosis. J ournal of Cell Sci ence, 107:3105-3114 . Schlech, W.F. III, Luo, Q., Faulkner, G. and Galsworthy, S. (1994) Interaction of Listeria species with human cell monolayers. Clinical and Inves tigative Medicine, 17:9-17. Bessesen, M., Luo, Q., Rotbart, H.A., Blaser, M.J. and Ellison, R.T. III. (1990)Detection of Listeria monocytogenes by using the Polymerase Chain Reaction. Applied and Environmental Microbiology, 56:2930-2932. Ellison, R.T. III, Luo, Q. and Reller, L.B. (1990) Enhancement of the activity of cefotaxime by iron-binding proteins. J ournal of Antimicrobial Chemotherapy, 25:479-481.

	Book:
	Chang, D.C., Zhou, L.Y. and Luo, K.Q. (2005) Using GFP and FRET technologies for studying signaling mechanisms of apoptosis in a single living cell. In: Shen, X. and Wijk, R.V. (eds.) Biophotonics-Optical Science and Engineering for the 21 st Century. Springer, New York. pp 25-38.

	Patents:
	Ng, K.M., Luo, K.Q., Zhang, E.J. and Harjo, B. A health care product containing isoflavone aglycones and method of preparing the same. US Patent No. US 7,553,505 B2, granted on June 30, 2009. Chang , D.C. and Luo, K.Q. Nucleic Acid encoding fluorescent protein construct s and methods for detecting apoptosis. US Patent No. US 7,354,735 B2, grante d on April 8, 200 8 . Chang , D.C. and Luo, K.Q. Intra-molecular modification of GFP (green fluorescent protein) for detecting apoptosis and specific enzyme activity in living cells. US Patent No. US 7,049,400, granted on May 23, 2006. Chang , D.C. and Luo, K.Q. GFP-based methods for detecting apoptosis. PRC Patent Application No. ZL 02 1 20427.6, granted on May 3, 2006. Luo, K.Q., Chang, D.C., Tian, H.L. and Luo, H.W. Use of acetyltanshinone as an anti-cancer drug. US Patent Application No. 60/879,171, filed in January 9, 2007. Luo, K.Q . and Chang, D.C. A fluorescence resonance energy transfer (FRET)-based high throughput drug screening method for discovery of anti-cancer compounds from herbal medicine. US Patent Application No. 60/848,674, filed in October 3, 2006.

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